Lung ultrasound (LUS) is a valid tool for the assessment of pulmonary congestion in patients with heart failure. However, whether LUS congestion predicts clinical outcomes in heart failure has yet to be widely validated. We investigated the presence of an association between the grade of residual pulmonary congestion assessed by LUS at hospital discharge and 3-month clinical outcomes in patients with heart failure.
Materials and methodsA prospective observational study was conducted on 85 patients who presented with heart failure during hospitalization in the Cardiac Rehabilitation Unit at the Federico II University Hospital of Naples from March 2021 until September 2022. The study was conducted in accordance with the principles of the Declaration of Helsinki. All participants signed the informed consent before participating.LUS was performed at hospital discharge using LUS score as an ultrasound indicator of pulmonary congestion. To calculate the LUS score, both hemithoraxes were topographically divided into six regions, each of which was assigned a score from 0 to 3: 0, 0-3 B-lines; 1, >3 B-lines; 2, confluent B-lines; 3, white lung. 1 Clinical, echocardiographic, and laboratory values were collected at admission and hospital discharge. CKD was defined as an eGFR below 60 ml/min/1.73 m 2 using the CKD-EPI formula.Remote monitoring was performed through dedicated phone calls at 90 days after hospital discharge to evaluate new-onset/worsening dyspnea, cardiovascular rehospitalization, angina, and death from cardiovascular causes. We investigated the relationship between available variables and clinical outcomes using a multivariable logistic regression model with converging backward and forward stepwise selection. Multicollinearity was evaluated using the variance inflation factor. All statistical analyses were performed using R (R Foundation). Two-sided P-value less than 0.05 was considered significant.
ResultsBaseline characteristics of the enrolled population are summarized in Table 1. The study population was composed of patients with heart failure, 70.5% recovering from an acute myocardial infarction, 20.0% recovering from an acute heart failure event and 9.5% recovering after a complex elective coronary revascularization.
Research Letterà Andrea Perillo and Christian Basile share the first authorship.