Lung tumors: Early and delayed ratio of 99mTc-methoxy-2-isobutylisonitrile accumulation

Nikoletic, Katarina; Mihaïlovic, Jasna; Srbovan, Dolores; Коларов,; Žeravica, Radmila

doi:10.2298/vsp120806052n

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…The literature search process is demonstrated as a flowchart in Figure 1 . Of the 15 articles deemed eligible for inclusion, 10 , 12 , 27 – 30 , 32 – 39 one pair of article by Nikoletic et al 31 , 32 had overlapping data; thus, only the latest article 32 was included. Consequently, the final review comprised 14 studies.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Performances of 99mTc-Methoxy Isobutyl Isonitrile Scan in Predicting the Malignancy of Lung Lesions

Shuxin

Liu

2016

Medicine

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We performed a meta-analysis to evaluate the value of technetium-99m methoxy isobutyl isonitrile (99mTc-MIBI) single photon emission computed tomography (SPECT) in differentiating malignant from benign lung lesions.The PubMed and Embase databases were comprehensively searched for relevant articles that evaluated lung lesions suspicious for malignancy. Two reviewers independently extracted the data on study characteristics and examination results, and assessed the quality of each selected study. The data extracted from the eligible studies were assessed by heterogeneity and threshold effect tests. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and areas under the summary receiver-operating characteristic curves (SROC) were also calculated.Fourteen studies were included in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio, and DOR of 99mTc-MIBI scan in detecting malignant lung lesions were 0.84 (95% confidence interval [CI]: 0.81, 0.87), 0.83 (95% CI: 0.77, 0.88), 4.22 (95% CI: 2.53, 7.04), 0.20 (95% CI: 0.12, 0.31), and 25.71 (95% CI: 10.67, 61.96), respectively. The area under the SROC was 0.9062. Meta-regression analysis showed that the accuracy estimates were significantly influenced by ethnic groups (P < 0.01), but not by image analysis methods, mean lesion size, or year of publication. Deek funnel plot asymmetry test for the overall analysis did not raise suspicion of publication bias (P = 0.50).Our results indicated that 99mTc-MIBI scan is a promising diagnostic modality in predicting the malignancy of lung lesions.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Performances of 99mTc-Methoxy Isobutyl Isonitrile Scan in Predicting the Malignancy of Lung Lesions

Shuxin

Liu

2016

Medicine

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“…Однофотонная эмиссионная компьютерная томография (ОФЭКТ) с Тс-МИБИ широко применяется для оценки перфузии миокарда левого желудочка, а в последнее десятилетие этот метод активно внедряется в клиническую практику диагностики опухолевых поражений легких. Анализ работ, посвященных применению метода ОФЭКТ/КТ с 99m Тс-МИБИ в оценке опухолевого поражения легких [2][3][4][5][6][7][8], показывает, что исследования сильно отличались по величине дозы вводимого препарата (335-1000 МБк) и параметрам записи сырых данных (60-120 ракурсов, время экспозиции 10-30 сек, интервал времени между введением трассера и сканированием 5-40 мин). Практически отсутствует информация о характеристиках используемых алгоритмов реконструкции (число подмножеств subsets, номер итерации останова), от которых может сильно зависеть полученное решение.…”

Section: Introductionunclassified

Potentials of computer simulation of lung tumors in comparison with <sup>99m</sup>Тс-MIBI SPECT/CT data

et al. 2023

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The aim of the study was to develop and validate a software package (SP) for computer simulation of the procedure for examining patients with lung cancer by SPECT/CT and assessing the accuracy of reconstruction of tumor lesions.Material and Methods. Lung scintigraphy for a patient with peripheral squamous cell carcinoma of the upper lobe of the right lung was performed using a two-detector gamma camera GE Discovery NM/CT 670 DR (USA) with high-resolution collimators for an energy of 140 KeV and a radiopharmaceutical (RP) 99mTc-Technetril (MIBI, Diamed, Moscow). The data obtained were subjected to computer processing using a specialized Xeleris 4.0 system from GE (USA). The SP included a program for generating a voxel phantom (“virtual patient”), a program for modeling the “raw” data acquisition (“virtual tomograph”) and an image reconstruction based on the OSEM algorithm (Ordered Subset Expectation Maximization). In order to validate the created SP, computer simulation of the above clinical case was performed. The semi-quantitative comparative image analysis was based on a tumor/background score.Results. There was a good correlation between clinical “raw” data recorded from a real patient and projection data calculated by the Monte Carlo method from a “virtual patient”. The results of the comparative analysis showed that the tumor/background assessment was underestimated in the reconstructed images.Conclusion. The problem of the accuracy of the tumor lesions reconstruction by using standard OSEM reconstruction algorithms has not been studied. This issue is important in the management of patients with tumor lesions of the lungs and requires study and systematization. The SP will be used in further studies to analyze errors and artifacts in images of tumor lesions, as well as to develop approaches to overcome them.

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Lung tumors: Early and delayed ratio of 99mTc-methoxy-2-isobutylisonitrile accumulation

Cited by 2 publications

References 12 publications

Diagnostic Performances of 99mTc-Methoxy Isobutyl Isonitrile Scan in Predicting the Malignancy of Lung Lesions

Diagnostic Performances of 99mTc-Methoxy Isobutyl Isonitrile Scan in Predicting the Malignancy of Lung Lesions

Potentials of computer simulation of lung tumors in comparison with <sup>99m</sup>Тс-MIBI SPECT/CT data

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