Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography

Duhaylongsod, Francis G.; Lowe, Val J.; Patz, Edward F.; Vaughn, Anna; Coleman, R. Edward; Wolfe, Walter G.

doi:10.1016/0003-4975(95)00754-9

Cited by 215 publications

(103 citation statements)

References 14 publications

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“…Some authors have identified a correlation between size and SUV [16–18], whereas others did not [19,20]. We found a significant correlation between SUVmax and size (r=0.32; p=0.048): this correlation was stronger for lesions larger than 31 mm (r=0.4515; p=0.0268).…”

Section: Discussioncontrasting

confidence: 39%

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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BackgroundPersonalized cancer therapy remains a challenge. In this context, we attempted to identify correlations between tumour angiogenesis, tumour metabolism and tumour cell type. To this aim, we used single=phase multidetector computed tomography (MDCT) and hybrid positron emission tomography-computed tomography (PET/CT) to determine whether net enhancement and standardized uptake value (SUVmax) were correlated with tumour size and cytology in patients affected by non-small cell lung cancer (NSCLC).Material/MethodsOur study included 38 patients (30 men, 8 women, mean age 70) with a NSCLC measuring between 3 cm and 7 cm, using a 16-slice multidetector CT (Brilliance Philips) and with PET-CT (Biograph 16 Siemens Medical Solutions). The following lesion parameters were evaluated: maximum diameter, medium density before contrast injection (CTpre), medium density after contrast injection (CTpost average), density in the most enhanced part of the lesion after contrast (CTpost max), net enhancement, SUVmax, age, and cytology. Correlation coefficient and p-value were computed for each pair of variables. In addition, correlations were computed for each pair of variables, and for all combinations of tumour types. We focused on subsets of data with more than 10 observations, and with correlation r>0.500 and p<0.05.ResultsA weak correlation (r=0.32; p=0.048) was found between SUVmax and tumour size; the correlation was stronger for masses larger than 31 mm (r=0.4515; p=0.0268). No other correlations were found among the variables examined.ConclusionsOur data may have prognostic significance, and could lead to more appropriate surgical treatment and better treatment outcome.

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Section: Discussioncontrasting

confidence: 39%

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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“…Brown et al (1999) observed a correlation between FDG uptake and tumour diameter in 23 lung cancers while Duhaylongsod et al (1995) didn't find any correlation in 36 primary lung tumours. In the present study FDG uptake measured by SUV was significantly correlated with nodule size when including both PET positive and negative metastases, but no significance was observed when only PET positive metastases were considered for analysis (P-value=0.4).…”

Section: Clinicalmentioning

confidence: 98%

Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases

et al. 2002

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Neoangiogenesis and enhanced glucose metabolism in neoplasms are likely to be activated by the same biochemical stimulus; hypoxia. A correlation between these two parameters has been postulated. The objective of this study was to evaluate the relationship between Fluoro-desoxi-glucose uptake at positron emission tomography scan and angiogenesis in lung metastasis. Fluoro-desoxi-glucose activity, expressed as a standard uptake value, and microvessel intratumoural density, were retrospectively calculated in a series of 43 lung metastasis resected in 19 patients. Primary sites were colorectal cancer in 16 metastases, sarcoma in eight, gynaecological in four and other sites in 15. The correlation between the two parameters was tested by logistic regression and multivariate analysis. Positron emission tomography scan was positive in 17 patients (sensitivity 89%). No correlation was observed between standard uptake value and microvessel intratumoural density in this series of lung metastasis. Positron emission tomography negative and positive nodules presented comparable value of microvessel intratumoural density (12.9 vs 11.3). Standard uptake value was significantly correlated with nodules size and was higher in colon cancer metastasis than in sarcoma ones. Microvessel intratumoural density was independent from nodule size but significantly higher in sarcoma than in colon cancer metastasis. The lack of correlation was confirmed by multivariate analysis after adjustment for tumour type and nodules size. The present study demonstrated that positron emission tomography scan is positive in a high proportion of patients regardless of microvessel density. Glucose uptake and angiogenesis appear to be independent biological features in lung metastasis. This observation may have implications for future antiangiogenic therapies.

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“…PET performed with this agent exploits the differences in glucose metabolism between normal and neoplastic cells, allowing accurate, noninvasive differentiation of benign versus malignant abnormalities [49]. Uptake of FDG is known to be proportional to tumour aggressiveness and growth rates [50]. FDG uptake can be assessed visually on PET images ( fig.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

121

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography

Cited by 215 publications

References 14 publications

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases

Diagnostic imaging of lung cancer

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