Lung transplantation: the Cleveland Clinic experience

Patel, Sunit R.; Kirby, Thomas J.; McCarthy, Patrick M.; Meeker, David P.; Stillwell, Paul C.; Rice, Thomas W.; Kavuru, Mani S.; Mehta, Atul C.

doi:10.3949/ccjm.60.4.303

Cited by 24 publications

(8 citation statements)

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“…Airway complications are among the most challenging problems in lung transplant patients and currently occur in up to 27% of recipients. [1][2][3][4][5][6][7][8][9][10][11] The cause of abnormal bronchial healing after lung transplantation is probably multifactorial. Donor organ ischemia is thought to play a significant role in the development of these complications.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Experience With a New Removable Tracheobronchial Stent in the Management of Airway Complications After Lung Transplantation

Fernández-Bussy

Akindipe

Kulkarni

et al. 2009

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11] A review of our institutional experience indicates that 24% of our lung transplant recipients have airway complications. These complications have been attributed to a lack of blood flow to the donor tracheobronchial tree that invariably occurs during the first few days after surgery.…”

mentioning

confidence: 99%

Clinical Experience With a New Removable Tracheobronchial Stent in the Management of Airway Complications After Lung Transplantation

Fernández-Bussy

Akindipe

Kulkarni

et al. 2009

The Journal of Heart and Lung Transplantation

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“…CMV gram was begin in 1990, and details regarding the program have infection was defined as isolation of CMV from blood (virebeen reported previously [7]. Prophylaxis for cytomegalovirus mia), respiratory secretions (bronchoalveolar lavage fluid), or (CMV) infection was used for all lung transplant recipients urine in the absence of recognition of inclusion bodies in tissue.…”

Section: Methodsmentioning

confidence: 99%

Cytomegalovirus Infection Is a Risk Factor for Invasive Aspergillosis in Lung Transplant Recipients

et al. 1998

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Invasive aspergillosis (IA) remains a major cause of morbidity and mortality following solid organ transplantation. To assess the incidence of IA following lung transplantation and to identify risk factors for its occurrence, we performed a case-control study involving 101 patients undergoing lung transplantation at our institution from 1990 to 1995 and reviewed the findings. Fourteen patients (14%) developed IA. The mean time from transplantation to diagnosis was 15 months. Nine patients died; the mean time to death from diagnosis was 13 days. Risk factors associated with developing IA included concomitant cytomegalovirus (CMV) pneumonia or viremia and culture isolation of Aspergillus species from a respiratory tract specimen after lung transplantation. Optimal strategies to prevent IA in lung transplant recipients remain to be determined, but prevention of aspergillus airway colonization and CMV viremia and disease after transplantation may be important targets for prophylactic interventions.

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“…Bacterial infections occur in 33 to 68% of liver transplant recipients, 21 to 30% of heart transplant recipients, 35% of pancreas transplant recipients, 47% of kidney transplant recipients, and 54% of lung transplant recipients, although the severity of infection varies among these populations (38,75,133,217,218,242,251,412,414,509,514,519,736) (Table 3).…”

Section: Common Bacterial Infectionsmentioning

confidence: 99%

“…Risk factors for bacterial infections in liver transplant recipients include CMV infection, acute rejection, prolonged hospitalization, increased operative transfusion requirement, prolonged duration of surgery, rejection, reoperation, elevated creatinine levels, retransplantation, and elevated bilirubin levels; pretransplantation antibacterial agents may have a protective effect (133,218,427,519,736). In liver transplant recipients, the presence of a Roux-en-Y choledochojejunostomy increases the risk of sepsis overall, infectious complications related to liver biopsy, and enterococcal and pseudomonas bacteremia (83, a Data are from large studies in a variety of transplantation centers (31,38,119,133,203,213,217,218,242,251,299,301,317,369,376,379,412,414,434,464,509,514,519,529,585,637,714,736,748,754,775).…”

Section: Common Bacterial Infectionsmentioning

confidence: 99%

Infections in solid-organ transplant recipients

1997

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Solid-organ transplantation is a therapeutic option for many human diseases. Infections are a major complication of solid-organ transplantation. All candidates should undergo a thorough infectious-disease screening prior to transplantation. There are three time frames, influenced by surgical factors, the level of immunosuppression, and environmental exposures, during which infections of specific types most frequently occur posttransplantation. Most infections during the first month are related to surgical complications. Opportunistic infections typically occur from the second to the sixth month. During the late posttransplant period (beyond 6 months), transplantation recipients suffer from the same infections seen in the general community. Opportunistic bacterial infections seen in transplant recipients include those caused by Legionella spp., Nocardia spp., Salmonella spp., and Listeria monocytogenes. Cytomegalovirus is the most common cause of viral infections. Herpes simplex virus, varicella-zoster virus, Epstein-Barr virus and others are also significant pathogens. Fungal infections, caused by both yeasts and mycelial fungi, are associated with the highest mortality rates. Mycobacterial, pneumocystis, and parasitic diseases may also occur.

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Lung transplantation: the Cleveland Clinic experience

Cited by 24 publications

References 0 publications

Clinical Experience With a New Removable Tracheobronchial Stent in the Management of Airway Complications After Lung Transplantation

Clinical Experience With a New Removable Tracheobronchial Stent in the Management of Airway Complications After Lung Transplantation

Cytomegalovirus Infection Is a Risk Factor for Invasive Aspergillosis in Lung Transplant Recipients

Infections in solid-organ transplant recipients

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