Lung transplantation for pulmonary alveolar microlithiasis: a case report

Samano, Marcos Naoyuki; Waisberg, Daniel Reis; Canzian, Mauro; Campos, Sílvia Vidal; Pêgo-Fernandes, Paulo Manuel; Jatene, Fábio Biscegli

doi:10.1590/s1807-59322010000200016

Cited by 39 publications

(51 citation statements)

References 11 publications

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“…Single transplants were reported in 1996 in Saudi Arabia [66], in 2001 in Canada [67], in 2009 in Iran [68] and in 2014 in Italy [69]. Four other bilateral transplants were performed in France in 2009 [70], in Brazil in 2010 [71], in the USA in 2010 [72] and 2011 [73] and five in Vienna between 1989 and 2013 (one of these was also published by GÜÇYETMEZ et al [74,75]). The longest-living trasplanted patient is a 63-year-old female [72].…”

Section: Therapy and Lung Transplantationmentioning

confidence: 98%

“…To date, no recurrence after transplantation has been reported, confirming that PAM is caused by a local alteration in the alveolar metabolism. Finally, the normalisation of the right ventricular ejection fraction and the regression of right ventricular hypertrophy strongly suggest that surgery can be an effective treatment option for end-stage PAM patients [71].…”

Section: Therapy and Lung Transplantationmentioning

confidence: 99%

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Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide

et al. 2015

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Pulmonary alveolar microlithiasis (PAM) is a rare disease characterised by the widespread intra-alveolar accumulation of minute calculi called microliths. It is caused by mutation of the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. The present study explores the epidemiological, familial, genetic, clinical, diagnostic, radiological and therapeutic aspects with the aim of contributing to a better understanding of this uncommon disease.We searched articles on PAM published up to December 2014 and 544 papers were found, accounting for 1022 cases.PAM is present in all continents and in many nations, in particular in Turkey, China, Japan, India, Italy and the USA. Familiality is frequent. The clinical course is not uniform and the causes of this clinical variability seem to be largely nongenetic. The optimal diagnostic procedure is the association of chest high-resolution computed tomography (HRCT) with bronchoalveolar lavage, but a chest radiograph may suffice in families in which a case has already been diagnosed. Moreover, chest radiography and HRCT allow the classification of the evolutionary phase of the disease and its severity. At present lung transplantation is the only effective therapy. However, better knowledge of the gene responsible offers hope for new therapies. @ERSpublications Familial, genetic, clinical, radiological and therapeutic aspects of pulmonary alveolar microlithiasis epidemiology http://ow.ly/St3Mw

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Section: Therapy and Lung Transplantationmentioning

confidence: 98%

Section: Therapy and Lung Transplantationmentioning

confidence: 99%

Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide

et al. 2015

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“…transplantations instead of unilateral transplants on the grounds of resistant shunt development in a lung transplantation series of 14 cases, one of which was caused by PAM 12 . Besides, no recurrence was detected in the presented cases or series 7,8,10,13,14 . Moon et al reported the case of a patient who survived for 15 postoperative years with no recurrence after the lung transplantation was performed after PAM diagnosis 8 .…”

Section: Discussionmentioning

confidence: 52%

“…Lung transplantation is a treatment option for PAM patients and is recommended in severe cases of oxygen dependent respiratory failure before the onset of right heart failure 7,8,10 . Bonette et al recommended bilateral lung -The risk of recurrence should not be considered as a justifying reason to avoid the transplantation option.…”

Section: Discussionmentioning

confidence: 99%

Lung transplantation in an intensive care patient with pulmonary alveolar microlithiasis - a case report

Güçyetmez¹,

Ogan²,

Ayyıldız³

et al. 2014

F1000Res

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“…18 Until 2010, 7 patients had received lung transplantation for this condition. 19 To date, recurrence has not been reported in the transplanted lung, suggesting that, in fact, the PAM is a genetically determined disorder rather than a systemic disease.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Micronodular Pulmonary Infiltrate: Is It Important to Make a Histological Diagnosis?

Khan

Gilmartin

2012

Respir Care

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Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate within the alveoli. We report the case of a 20-year-old man with a 6-week history of cough and shortness of breath on exertion. The chest radiograph demonstrated a bilateral symmetrical micronodular pattern. High-resolution computed tomography revealed bilateral diffuse fine nodular shadowing involving the mid zones, with sparing of the apices. The patient underwent a transbronchial lung biopsy, which confirmed the diagnosis of pulmonary alveolar microlithiasis.

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Lung transplantation for pulmonary alveolar microlithiasis: a case report

Cited by 39 publications

References 11 publications

Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide

Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide

Lung transplantation in an intensive care patient with pulmonary alveolar microlithiasis - a case report

Bilateral Micronodular Pulmonary Infiltrate: Is It Important to Make a Histological Diagnosis?

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