Lung Transplantation for Patients Older Than 65 Years: Is It a Feasible Option?

Machuca, Tiago; Camargo, Spencer Marcantônio; Schio, Sadi Marcelo; Lobato, Vivalde; Sánchez-Valdeón, Leticia; Perin, Fabíola Adélia; Felicetti, José Carlos; Camargo, José de Jesus Peixoto

doi:10.1016/j.transproceed.2010.12.010

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Several investigations have previously demonstrated acceptable outcomes, including survival and functional status, among carefully selected recipients aged 65 years and older relative to younger cohorts. [10][11][12][13] Nonetheless, survival is still inferior in these age groups. 14 In the present study, we observed poorer survival in recipients ≥65 years relative to the youngest cohort.…”

Section: Discussionmentioning

confidence: 99%

“…There is currently no consensus regarding an age cut‐off for performing LTx. Several investigations have previously demonstrated acceptable outcomes, including survival and functional status, among carefully selected recipients aged 65 years and older relative to younger cohorts 10–13 . Nonetheless, survival is still inferior in these age groups 14 .…”

Section: Discussionmentioning

confidence: 99%

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Outcomes after lung transplantation in recipients aged 70 years or older

Olson

Elnahas

Roy

et al. 2021

Clinical Transplantation

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Background:The proportion of lung transplant (LTx) recipients older than 70 years is increasing, thus we assessed long-term survival after LTx in this cohort relative to younger counterparts. Patients and methods:We retrospectively reviewed charts of patients who underwent LTx between 2012 and 2016 at our center and divided patients by age: group A (<65 years), B (65-69 years), and C (≥70 years). Survival statistics were evaluated using the Kaplan-Meier method and Cox regression. Results:The study included 375 LTx recipients: 221 (58.9%) in group A, 109 (29.1%) in group B, and 45 (12.0%) in group C. Group C was mostly men (37/45 [82.2%]; P = 0.003) and had the highest mean serum creatinine at listing (P = 0.02). Survival at 1, 3, and 5 years after transplant in group A (93.2%, 70.1%, 58.8%) was significantly higher than group B (83.5%, 59.6%, 44.0%; P = 0.005, 0.028, 0.006, log-rank test) and was similar to group C (86.7%, 64.4%, 57.8%), although trended higher at 1 year (P = 0.139, 0.274, 0.489, log-rank test). Groups B and C had comparable survival at all time points. Conclusions:Although survival decreased after age 65, long-term survival was comparable between LTx recipients aged 65-69 years and recipients ≥70 years.

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