Lung Transplantation for Cystic Fibrosis

Adler, Frederick R.; Aurora, Paul; Barker, David H.; Barr, Mark L.; Blackwell, Laura S.; Bosma, O. H.; Brown, Samuel M.; Cox, David; Jensen, Judy L; Kurland, Geoffrey; Nossent, George; Quittner, Alexandra L.; Robinson, Walter M.; Romero, Sandy; Spencer, Helen; Sweet, Stuart C.; Bij, Wim van der; Vermeulen, Jill M. Kolesar Lee; Verschuuren, Erik; Vrijlandt, Elianne J.L.E.; Walsh, William R.; Woo, Marlyn S.; Liou, Theodore G.

doi:10.1513/pats.2009008-088tl

Cited by 70 publications

(36 citation statements)

References 231 publications

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“…Experts from the US, Canada, UK, and The Netherlands carefully considered how efforts to improve the outcome of PT for CF lung disease might best be studied, bearing in mind that improvements should focus on candidate selection criteria and optimized timing of referral for transplantation [72].…”

Section: Lung Transplantationmentioning

confidence: 99%

An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea

Salvatore

Buzzetti

Baldo

et al. 2011

Journal of Cystic Fibrosis

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This is the third article related to a review of the literature based on data from national cystic fibrosis (CF) patient registries up to June 2008 and covering a total of 115 published studies. It focuses on several topics: CF incidence, genotype/phenotype correlation, microbiology, pregnancy/paternity, clinical complications, lung transplantation, and others. Seventy seven papers meeting the inclusion criteria were found to be related to the topics listed above. Another seven studies, already evaluated in previous papers of this series, were recalled for specific topics. Incidence is described by several studies, results being quite different from one country to another and quite inhomogeneous among regions within the same country. Studies on genetics address the genotype/phenotype correlation and look for a predictive value of CFTR mutations in terms of clinical outcome, with controversial results. Papers on microbiology describe the clinical relevance of different pathogens and their role in the progress of CF lung disease. A few articles give information on the features of CF women undergoing a pregnancy and try to identify the ones associated with a better outcome. Studies on clinical complications discuss prevalence and the role of haemoptysis, pneumothorax, CF related diabetes, ABPA and cancer. Papers on lung transplantation focus on models able to improve the selection criteria for transplantation candidates and the factors linked to post transplantation survival. Finally, several studies deal with a number of interesting topics related to CF epidemiology: clinical trial methodology, quality of care comparison among countries and centers, relationship between diagnosis and age/gender, and evaluation of pharmacological therapy. On the whole, CF Registries have already contributed to important advances in the knowledge of the natural history of CF, establishing the foundations for future improvement in CF research and care.

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Section: Lung Transplantationmentioning

confidence: 99%

An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea

Salvatore

Buzzetti

Baldo

et al. 2011

Journal of Cystic Fibrosis

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“…53,54,56,184,185 Aunque algunas de las publicaciones son en base a series de números reducidos de casos. En nuestro país solo se han encontrado dos publicaciones sobre TP en pacientes con FQ, una de ellas en las que se engloba a los pacientes con FQ dentro de las enfermedades supurativas y otra en la que se sugiere que la CEC, entre otras causas, disminuye la supervivencia de los pacientes pediátricos con FQ que reciben un TP.…”

Section: -183unclassified

El trasplante pulmonar en la fibrosis quística y la influencia de la circulación extracorpórea

Deu

Romero

Román

et al. 2018

Archivos de Bronconeumología

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“…With rising costs, particularly for the critically-ill, and limited transplant resources, a prospective trial of lung transplantation must be done. A trial design that entails forgoing transplantation altogether for some patients is unlikely to be acceptable to either patients or practitioners, but a trial where patients randomly exchange LAS, perhaps similar to what we have previously proposed for patients with cystic fibrosis, 192 may derive sufficient data to better evaluate survival benefit without gross disruption of current practice.…”

Section: Lung Transplantation In Copd and Life Extensionmentioning

confidence: 99%

Lung transplantation for chronic obstructive pulmonary disease

Liou¹,

Raman²,

Cahill³

2013

TRRM

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Abstract:Patients with end-stage chronic obstructive pulmonary disease (COPD) comprise the largest single lung disease group undergoing transplantation. Selection of appropriate candidates requires consideration of specific clinical characteristics, prognosis in the absence of transplantation, and likely outcome of transplantation. Increased availability of alternatives to transplantation for end-stage patients and the many efforts to increase the supply of donor organs have complicated decision making for selecting transplant candidates. Many years of technical and clinical refinements in lung transplantation methods have improved survival and quality of life outcomes. Further advances will probably come from improved selection methods for the procedure. Because no prospective trial has been performed, and because of confounding and informative censoring bias inherent in the transplant selection process in studies of the existing experience, the survival effect of lung transplant in COPD patients remains undefined. There is a lack of conclusive data on the impact of lung transplantation on quality of life. For some patients with end-stage COPD, lung transplantation remains the only option for further treatment with a hope of improved survival and quality of life. A prospective trial of lung transplantation is needed to provide better guidance concerning survival benefit, resource utilization, and quality of life effects for patients with COPD.

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Lung Transplantation for Cystic Fibrosis

Cited by 70 publications

References 231 publications

An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea

An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea

El trasplante pulmonar en la fibrosis quística y la influencia de la circulación extracorpórea

Lung transplantation for chronic obstructive pulmonary disease

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