Lung Transplantation

Fg, Pearson

doi:10.1001/archsurg.1989.01410050025003

Cited by 15 publications

(1 citation statement)

References 18 publications

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“…Patients may be offered either single lung [l], double lung [2], heart-lung [3,4], or even unilateral lung-heart [5] transplants, depending on each individual's circumstances. Advances in organ preservation, surgical technique, and immunosuppression have resulted in long-term patient survival [6-81. Management of transplant patients in the early postoperative period remains a significant challenge.…”

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confidence: 99%

Critical Care Management of Lung Transplant Recipients

Bierman

Stein

Stuart

et al. 1991

J Intensive Care Med

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In the last 10 years, lung transplantation has become an increasingly common procedure for patients with end-stage respiratory disease. Although long-term survival can be achieved, there is still significant morbidity within the first year. Early postoperative problems that may be anticipated include respiratory insufficiency, airway anastomotic problems, hemorrhage, infection, and episodes of acute rejection. These problems and others make the immediate perioperative period particularly challenging. With aggressive management, however, the probability of a successful outcome can be enhanced.

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confidence: 99%

Critical Care Management of Lung Transplant Recipients

Bierman

Stein

Stuart

et al. 1991

J Intensive Care Med

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The “Burst” of Pulmonary Transplantation: Thirty Years of Progress

Dauber

1994

Rejection and Tolerance

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Lung and heart-lung transplantation

LeGal¹

1990

The Annals of Thoracic Surgery

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Unilateral lung transplantation has become a successful method for the treatment of end-stage pulmonary disease, whereas double-lung transplantation has provided benefit to patients with nonfibrotic lung disease such as emphysema and cystic fibrosis. In the past 5 years, 16 single-lung and 13 double-lung transplantations have been performed by the Toronto Lung Transplant Group in patients with end-stage lung disease. Seven perioperative and two late deaths have been recorded so far. Since the introduction of heart-lung transplantation at Stanford in 1981 and at Pittsburgh in 1982 for the treatment of Eisenmenger's syndrome and terminal pulmonary vascular disease, more than 350 combined heart-lung transplantations have been carried out throughout the world. Presently, the 2-year actuarial survival is about 62%. The long-term results have not yet reached the same level of success as those of cardiac transplantation alone. Although several factors have played a role in this difference, a prominent cause has been the lack of a reliable and simple method for pulmonary protection against prolonged ischemia. Most of the techniques proposed against ischemia can be classified as normothermic or static hypothermic cardiopulmonary preservation. The use of the normothermic method has not always been successful. For this reason, interest has now been directed toward the potential for hypothermic preservation of the heart-lung bloc and the use of free-radical scavenger therapy in the reduction of reperfusion injury.

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Lung Transplantation

Cited by 15 publications

References 18 publications

Critical Care Management of Lung Transplant Recipients

Critical Care Management of Lung Transplant Recipients

The “Burst” of Pulmonary Transplantation: Thirty Years of Progress

Lung and heart-lung transplantation

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