Lung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot study

Neemuchwala, Fatima; Mahani, Maryam Ghadimi; Pang, Yuxi; Lee, Eunjee; Johnson, Timothy D.; Galbán, Craig J.; Fortuna, Aleksa B.; Sánchez-Jacob, Ramón; Flask, Chris A.; Nasr, Samya Z.

doi:10.1007/s00247-020-04638-9

Cited by 9 publications

(13 citation statements)

References 27 publications

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“…Previous studies have suggested that T1 mapping can be used to evaluate the lung function of COPD and emphysema 4–8 . This study also showed that the mean T1 was a stable parameter with which to identify pathological types in lung cancer patients and those complicated with emphysema.…”

Section: Discussionsupporting

confidence: 59%

“…Previous studies have suggested that T1 mapping can be used to evaluate the lung function of COPD and emphy-sema. [4][5][6][7][8] This study also showed that the mean T1 was a stable parameter with which to identify pathological types in lung cancer patients and those complicated with emphysema. Therefore, it may be potentially used in the preoperative evaluation of these patients, providing incremental diagnostic value beyond lung function information.…”

Section: Discussionmentioning

confidence: 99%

“…To date, T1 mapping has been mainly used in the field of cardiovascular imaging, where it has emerged as an important imaging tool for characterization of myocardial tissue 3 . To date, studies in the lung have mainly concentrated on the assessment of lung function, and shorter T1 relaxation times have been reported in patients with chronic obstructive pulmonary disease (COPD), emphysema, and interstitial fibrosis 4–8 . Additionally, it has been shown that T1 mapping is potentially able to differentiate benign and malignant pulmonary lesions and lymph nodes due to differences in their water content 9–11 .…”

mentioning

confidence: 99%

“…3 To date, studies in the lung have mainly concentrated on the assessment of lung function, and shorter T1 relaxation times have been reported in patients with chronic obstructive pulmonary disease (COPD), emphysema, and interstitial fibrosis. [4][5][6][7][8] Additionally, it has been shown that T1 mapping is potentially able to differentiate benign and malignant pulmonary lesions and lymph nodes due to differences in their water content. [9][10][11] Other studies have suggested that T1 mapping could also be used to determine histopathological grade 12,13 and to monitor the treatment response of tumors.…”

mentioning

confidence: 99%

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B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

Jiang

Cui

Xiao

et al. 2021

Magnetic Resonance Imaging

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Background T1 mapping can potentially quantitatively assess the intrinsic properties of tumors. B1 correction can reduce the magnetic field inhomogeneity. Purpose To assess the repeatability and reproducibility of B1‐corrected T1 mapping for lung cancer and the ability to identify pathological types. Study Type Prospective reproducibility study. Population Sixty lung cancer patients (22 with emphysema) with a total of 60 lesions (adenocarcinoma [n = 23], squamous cell carcinoma [n = 19], and small‐cell lung cancer [SCLC] [n = 18]). Field Strength/Sequence A 3 T/B1‐corrected 3D variable flip angle T1 mapping and free‐breathing diffusion‐weighted imaging. Assessment Intraobserver, interobserver, and test–retest reproducibility of minimum, maximum, mean, and SD of lung tumor T1 values were assessed. The correlation between mean T1 and apparent diffusion coefficient (ADC) and differences between different histological types of lung cancer were evaluated. Statistical Tests Intraclass correlation coefficients (ICCs), within‐subject coefficients of variation (WCVs), Bland–Altman plots, Pearson's correlation coefficient (r), and analysis of variance (ANOVA). A P value <0.05 was considered to be statistically significant. Results No significant differences were found in minimum, maximum, mean, and SD T1 values for repeated measurements (intraobserver and interobserver) and repeated examinations (P = 0.103–0.979). All parameters showed good intraobserver, interobserver and test–retest reproducibility (ICC, 0.780–0.978), except the maximum T1 value (ICC, 0.645–0.922). The mean T1 exhibited the best reproducibility and repeatability, with an average difference <6% for repeated measurements, <8% for repeated scans in lung cancer patients, and<10% for repeated scans in those with emphysema. The mean T1 correlated moderately with ADC (r = −0.580, −0.516, and −0.511 for observers A, B, and C). Both mean T1 and mean ADC were significantly different in SCLC patients compared with those in adenocarcinoma and squamous cell carcinoma patients. Data Conclusion The mean T1 from B1‐corrected T1 mapping is a repeatable parameter with the potential to identify histological types of lung cancer and thus may be a promising imaging biomarker for characterizing lung cancer. Evidence Level 1 Technical Efficacy Stage 2

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

Jiang

Cui

Xiao

et al. 2021

Magnetic Resonance Imaging

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“…This might be addressed by, eg, triggering data acquisition with an electrocardiogram (ECG) during multiple breath‐hold phases. Although such a procedure was successful in a pilot study in CF children, 7 performing acquisitions under spontaneous respiration is obviously preferable.…”

mentioning

confidence: 99%

Editorial for “Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics”

Beckmann

2020

Magnetic Resonance Imaging

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Bias field correction in hyperpolarized ¹²⁹Xe ventilation MRI using templates derived by RF‐depolarization mapping

Wang

Bier

et al. 2022

Magnetic Resonance in Med

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Purpose To correct for RF inhomogeneity for in vivo 129Xe ventilation MRI using flip‐angle mapping enabled by randomized 3D radial acquisitions. To extend this RF‐depolarization mapping approach to create a flip‐angle map template applicable to arbitrary acquisition strategies, and to compare these approaches to conventional bias field correction. Methods RF‐depolarization mapping was evaluated first in digital simulations and then in 51 subjects who had undergone radial 129Xe ventilation MRI in the supine position at 3T (views = 3600; samples/view = 128; TR/TE = 4.5/0.45 ms; flip angle = 1.5; FOV = 40 cm). The images were corrected using newly developed RF‐depolarization and templated‐based methods and the resulting quantitative ventilation metrics (mean, coefficient of variation, and gradient) were compared to those resulting from N4ITK correction. Results RF‐depolarization and template‐based mapping methods yielded a pattern of RF‐inhomogeneity consistent with the expected variation based on coil architecture. The resulting corrected images were visually similar, but meaningfully distinct from those generated using standard N4ITK correction. The N4ITK algorithm eliminated the physiologically expected anterior–posterior gradient (−0.04 ± 1.56%/cm, P < 0.001). These 2 newly introduced methods of RF‐depolarization and template correction retained the physiologically expected anterior–posterior ventilation gradient in healthy subjects (2.77 ± 2.09%/cm and 2.01 ± 2.73%/cm, respectively). Conclusions Randomized 3D 129Xe MRI ventilation acquisitions can inherently be corrected for bias field, and this technique can be extended to create flip angle templates capable of correcting images from a given coil regardless of acquisition strategy. These methods may be more favorable than the de facto standard N4ITK because they can remove undesirable heterogeneity caused by RF effects while retaining results from known physiology.

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Lung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot study

Cited by 9 publications

References 27 publications

B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

Editorial for “Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics”

Bias field correction in hyperpolarized ¹²⁹Xe ventilation MRI using templates derived by RF‐depolarization mapping

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Lung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot study

Cited by 9 publications

References 27 publications

B1‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

B1‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

Editorial for “Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics”

Bias field correction in hyperpolarized 129Xe ventilation MRI using templates derived by RF‐depolarization mapping

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Product

Resources

About

B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

B₁‐Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types

Bias field correction in hyperpolarized ¹²⁹Xe ventilation MRI using templates derived by RF‐depolarization mapping