Lung Resection for Treatment of Idiopathic Thrombocytopenic Purpura Associated With a Pulmonary Lymphoma

Elsayed, Hany; Hassan, Mahdi; Nash, Jennifer; Lyall, M H; Poullis, Michael

doi:10.1016/j.athoracsur.2009.07.031

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…IVIG is commonly used for the treatment of primary ITP with severe thrombocytopenia. Over the last decade, 16 patients with NHL-associated ITP have been described, excluding patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (Table 2) (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). In these case reports, severe thrombocytopenia in patients with secondary ITP and NHL was also treated with IVIG; this approach was ineffective in eight patients.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, MCL was diagnosed after the first administration of rituximab, so we changed the primary disease target to MCL and administered VR-CAP chemotherapy (bortezomib 1.3 mg/m 2 days 1, 4, 8, and 11; rituximab 375 mg/m 2 day 0; cyclophosphamide 500 mg/m 2 day 1; doxorubicin 33 mg/m 2 day 1; and prednisolone 60 mg/m 2 days 1-5); we modified the dose based on the patient's age. A review of the related literature (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) over the past decade confirmed that chemotherapy did not result in severe bleeding in any patients with ITP secondary to NHL. We explained to the patient that previous reports had shown no critical adverse events associated with this chemotherapy but noted that his platelet count was already low (<1.0×10 4 /μL) and might be further reduced as a result of chemotherapy-related bone marrow suppression.…”

Section: Case Reportmentioning

confidence: 91%

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Treatment of Secondary Immune Thrombocytopenia with Non-Hodgkin Lymphoma: A Case Report and Literature Review

et al. 2021

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Secondary immune thrombocytopenic purpura (ITP) with non-Hodgkin lymphoma (NHL) is a rare disease. Although some treatment regimens are available for primary ITP, the treatment strategy for secondary ITP remains unconfirmed. We herein report a 79-year-old man who was diagnosed with secondary ITP with mantle cell lymphoma. Although intravenous immunoglobulin (IVIG) has been considered an effective option for secondary ITP, similar to the treatment of primary ITP, our patient did not benefit from IVIG. A literature review including the current report revealed that IVIG was ineffective in all treated patients. Secondary ITP with NHL should be treated differently from primary ITP.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 91%

Treatment of Secondary Immune Thrombocytopenia with Non-Hodgkin Lymphoma: A Case Report and Literature Review

et al. 2021

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Imaging manifestations of autoimmune disease-associated lymphoproliferative disorders of the lung

Lee

et al. 2013

Clin Rheumatol

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Lymphoproliferative disorders (LPDs) may involve intrathoracic organs in patients with autoimmune disease, but little is known about the radiologic manifestations of autoimmune disease-associated LPDs (ALPDs) of the lungs. The purpose of our work was to identify the radiologic characteristics of pulmonary involvement in ALPDs. A comprehensive search for PubMed database was conducted with the combination of MeSH words. All articles which had original images or description on radiologic findings were included in this analysis. Also, CT images of eight patients with biopsy-proven lymphoproliferative disorder observed from our institution were added. Overall, 44 cases of ALPD were identified, and consisted of 24 cases of bronchus-associated lymphoid tissue lymphoma (BALToma), eight cases of non-Hodgkin's lymphoma (NHL), six cases of lymphoid interstitial pneumonia (LIP), two cases of nodular lymphoid hyperplasia, two cases of unclassified lymphoproliferative disorder, and one case each of lymphomatoid granulomatosis and hyperblastic BALT. Multiple nodules (n = 14, 32 %) and single mass (n = 8, 18 %) were the predominant radiologic manifestations. The imaging findings conformed to previously described findings of BALToma, NHL, or LIP. Data suggest that BALToma, NHL, and LIP are the predominant ALPDs of the lung, and ALPD generally shared common radiologic features with sporadic LPDs. Familiarity with ALPDs and their imaging findings may enable radiologists or clinicians to include the disease as a potential differential diagnosis and thus, to prompt early biopsy followed by appropriate treatment.

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Autoimmune phenomena in untreated and treated marginal zone lymphoma

Grabska

Dasanu

2011

Expert Opinion on Pharmacotherapy

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The course of MZL is accompanied by a variety of hematologic and non-hematologic autoimmune disorders. Whereas some of them could be secondary and related to the course of the MZL, others may be primary and might even favor the development of MZL itself. In addition, authentic autoimmune conditions have been documented with the use of rituximab as a single agent and the nucleoside analogs. Therefore, we believe caution should be exerted with the use of these agents in MZL patients with evidence of autoimmune disorders, as exacerbation of autoimmune phenomena can be anticipated. While the heterogeneity of the MZL subtypes represents an inherent limitation, integration of emerging information from immunology research laboratories and clinical practice could translate into improved outcomes of this disease spectrum.

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Lung Resection for Treatment of Idiopathic Thrombocytopenic Purpura Associated With a Pulmonary Lymphoma

Cited by 4 publications

References 4 publications

Treatment of Secondary Immune Thrombocytopenia with Non-Hodgkin Lymphoma: A Case Report and Literature Review

Treatment of Secondary Immune Thrombocytopenia with Non-Hodgkin Lymphoma: A Case Report and Literature Review

Imaging manifestations of autoimmune disease-associated lymphoproliferative disorders of the lung

Autoimmune phenomena in untreated and treated marginal zone lymphoma

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