Lung, Pleura, and Mediastinum

Herbert, Ronald A.; Janardhan, Kyathanahalli S.; Pandiri, Arun R.; Cesta, Mark F.; Chen, Vivian; Miller, Rodney A.

doi:10.1016/b978-0-12-391448-4.00023-x

Cited by 5 publications

(7 citation statements)

References 116 publications

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“…Ciliated cells function to move the mucous blanket and particulate matter up the airways. Club cells have multiple functions, including immune modulation, xenobiotic metabolism (possess cytochrome P-450-dependent mono-oxygenase system) and synthesis of components of the mucociliary blanket, and serve as a progenitor of ciliated cells [48,49]. Goblet cells secrete mucins, and serous cells produce secretions containing enzymes (bactericidal, for example).…”

Section: Comparative Anatomy Relevant To Ricin Toxicity By Inhalationmentioning

confidence: 99%

“…Goblet cells secrete mucins, and serous cells produce secretions containing enzymes (bactericidal, for example). Basal cells, found at the base of epithelial cell layers, are stem or progenitor cells for the epithelium [48,49]. Other cells that may be present within the respiratory tract epithelia include neurosecretory or neuroendocrine cells, brush cells (considered sensory receptors) and cells of the immune system [48][49][50].…”

Section: Comparative Anatomy Relevant To Ricin Toxicity By Inhalationmentioning

confidence: 99%

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Comparative Aspects of Ricin Toxicity by Inhalation

Stoll

Shenton

Green

et al. 2023

Toxins

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The pathogenesis of ricin toxicity following inhalation has been investigated in many animal models, including the non-human primate (predominantly the rhesus macaque), pig, rabbit and rodent. The toxicity and associated pathology described in animal models are broadly similar, but variation appears to exist. This paper reviews the published literature and some of our own unpublished data and describes some of the possible reasons for this variation. Methodological variation is evident, including method of exposure, breathing parameters during exposure, aerosol characteristics, sampling protocols, ricin cultivar, purity and challenge dose and study duration. The model species and strain used represent other significant sources of variation, including differences in macro- and microscopic anatomy, cell biology and function, and immunology. Chronic pathology of ricin toxicity by inhalation, associated with sublethal challenge or lethal challenge and treatment with medical countermeasures, has received less attention in the literature. Fibrosis may follow acute lung injury in survivors. There are advantages and disadvantages to the different models of pulmonary fibrosis. To understand their potential clinical significance, these factors need to be considered when choosing a model for chronic ricin toxicity by inhalation, including species and strain susceptibility to fibrosis, time it takes for fibrosis to develop, the nature of the fibrosis (e.g., self-limiting, progressive, persistent or resolving) and ensuring that the analysis truly represents fibrosis. Understanding the variables and comparative aspects of acute and chronic ricin toxicity by inhalation is important to enable meaningful comparison of results from different studies, and for the investigation of medical countermeasures.

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Section: Comparative Anatomy Relevant To Ricin Toxicity By Inhalationmentioning

confidence: 99%

Section: Comparative Anatomy Relevant To Ricin Toxicity By Inhalationmentioning

confidence: 99%

Comparative Aspects of Ricin Toxicity by Inhalation

Stoll

Shenton

Green

et al. 2023

Toxins

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“…Os principais fatores responsáveis pelo desencadeamento dos sinais clínicos e progressão da MRM incluem características do hospedeiro e do agente, infecções concomitantes, condições ambientais do alojamento e manejo inadequado (GRAHAM;SCHOEB, 2011;TEIXEIRA, 2014;HANSEN;NIELSEN, 2015;SAUNDERS, 2021). O sistema imune do hospedeiro pode estar comprometido pela infecção primária do M. pulmonis e favorecer a instalação de infecções secundárias, com especial destaque para infecções pelos vírus Sendai e o da sialodacriloadenite (SDAV), bem como pela bactéria Filobacterium rodentium (BOECK et al, 2010;GRAHAM;SCHOEB, 2011;BROWN;DONNELLY, 2012;HERBERT et al, 2018;SAUNDERS, 2021).…”

Section: Progressão Da Micoplasmose Respiratória Murinaunclassified

“…A MRM, doença de característica crônica, que se desenvolve de forma lenta e silenciosa, apresenta-se de maneira subclínica, principalmente em animais jovens (GRAHAM; SCHOEB, 2011;HERBERT et al, 2018;FROHLICH, 2020). Ratos com significativas lesões nos pulmões e diagnóstico positivo para MRM podem ser assintomáticos, e os sinais clínicos só aparecerão em estágios mais avançados ou ao final da doença (BOECK et al, 2010;BROWN;DONNELLY, 2012;CHAWLA et al, 2017).…”

Section: Sinais Clínicosunclassified

“…Na MRM, a cromodacriorreia é observada em conjunto com outros sinais clínicos principais como espirros frequentes, dispneia e estertores (DUTTON, 2020). Outros sinais clínicos relatados são prurido cutâneo intenso, postura curvada, pelos arrepiados, acentuada perda de peso, apatia e a torção da cabeça (BROWN;DONNELLY, 2012;HANSEN;NIELSEN, 2015;ROMAGNANO, 2017;HERBERT et al, 2018;SAUNDERS, 2021).…”

Section: Prevenção E Tratamentounclassified

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Micoplasmose respiratória murina em ratos (Rattus norvegicus): revisão de literatura

Palladino

Biegelmeyer

2021

Rev. Educ. Cont. Med. Vet. Zootec.

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O Mycoplasma pulmonis é o agente etiológico primário da micoplasmose respiratória murina (MRM), uma importante patologia em ratos de laboratório. Os ratos são considerados ferramentas fundamentais em pesquisas experimentais há muito tempo, e ao decorrer dos anos é possível observar a sua crescente criação como animais de companhia e sua crescente presença em clínicas veterinárias. A MRM é uma patologia crônica e muitas vezes apresenta-se de maneira subclínica. Sua progressão é principalmente associada ao manejo inadequado, ressaltando a importância do conhecimento sobre os aspectos da MRM em ratos, sendo fundamental para a convivência saudável dos tutores com esses animais, além de ser uma ferramenta importante para a obtenção de resultados experimentais fidedignos.

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