Lung Perfusion Scintigraphy Early After COVID-19: A Single-Center Retrospective Study

De, Sajal; Ravina, Mudalsha; Lukose, Tinu Thadiyananickal; Ranganath, T G; Sahu, Dibakar

doi:10.2967/jnmt.121.262440

Cited by 8 publications

(7 citation statements)

References 18 publications

(20 reference statements)

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“…Low-dose chest CT scans can be added to various perfusion SPECT investigations to reduce false-positive outcomes. Sajal et al ., Ozturk et al ., and Das et al [10,33,34] showed that adding a low-dose CT scan to a perfusion SPECT may exclude patients with structural anomalies more accurately diagnose pulmonary embolism. Overall, the bulk of included studies recommended adding SPECT/CT to planar perfusion/ventilation scans to decrease the possibility of false positive cases.…”

Section: Discussionmentioning

confidence: 99%

“…Bahloul et al [16], two studies by Evbuomwan et al [24,25], Le Roux et al [29], Sajal et al [34], and Tan et al [37] reported pulmonary embolism prevalence by lung scintigraphy (VQ SPECT/CT). The prevalence ranged from 10.7% to 33.8%.…”

Section: Prevalence Of Pulmonary Embolism With Q or V/q Criteriamentioning

confidence: 99%

“…(2) Matched perfusion defects Matched perfusion defects on SPECT images were found in Cobes, Evboumwan, Kurkowska, Sajal, Tipre, Bonnefoy, and Venegas studies [18,21,24,28,34,38,39]. This pattern can virtually rule out pulmonary embolism as the culprit in the location of these abnormalities.…”

Section: Different Characteristics (Morphological Alterations) Of Cov...mentioning

confidence: 99%

“…There have been eight reports of diagnosis of pulmonary embolism with Q only SPECT CT: Das Jeeban et al [10], Evbuomwan et al [23], Acuna Hernandez et al [15], Fielding et al [26], Kurkowska et al [28], Sajal et al [34], Le Roux et al [29], Ozturk et al [33], and Tan et al All these studies showed that Q-SPECT/CT can be considered as an alternate method for detecting pulmonary embolism and with a high degree of certainty, a normal Q-SPECT/CT ruled out pulmonary embolism [37].…”

Section: Diagnosis Of Pulmonary Embolism With Q-only Spect Computed T...mentioning

confidence: 99%

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Diagnostic importance of lung perfusion/ventilation scans in the evaluation of pulmonary embolism in COVID-19 patients: systematic review of the literature

Rahmanipour

Ghorbani

Sadeghi

et al. 2022

Nuclear Medicine Communications

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Objective To investigate the outcomes of ventilation/ perfusion scintigraphy on the diagnosis of pulmonary embolism in coronavirus disease 2019 (COVID-19) patients, we performed a systematic review of the available literature. Materials and methodsPubMed and Scopus were systematically searched up to 4 June 2022, for relevant studies. We included studies on patients with COVID-19 who have performed ventilation/perfusion scintigraphy for diagnosis of pulmonary embolism to describe any diagnosis outcome. Irrelevant and non-English articles were excluded. ResultsOverall, 27 articles were included in our review. The database search yielded studies from PubMed, Scopus, and studies identified through reviewing the reference list of included studies. Extracted information from the included studies could be categorized into several aspects: Diagnosis of pulmonary embolism with Q single-photon emission computed tomography (SPECT) CT, Tracheobronchial uptake, Diagnostic value of V/Q rather than Q at diagnosis pulmonary embolism, Different characteristics (morphological alterations) of COVID-19 in ventilation orperfusion scan, the prevalence of pulmonary embolism with Q or V/Q criteria, and Design of radiotherapy planning in lung cancer patients with COVID-19. ConclusionDifferent perfusion patterns in COVID-19 are challenging but can be alleviated by adding SPECT/ computed tomography (CT) to lung perfusion scans. Although perfusion only SPECT/CT can rule out or rule in others in considerable number of patients, ventilation scan is still needed in certain patients. Nucl Med Commun

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Section: Discussionmentioning

confidence: 99%

Section: Prevalence Of Pulmonary Embolism With Q or V/q Criteriamentioning

confidence: 99%

Section: Different Characteristics (Morphological Alterations) Of Cov...mentioning

confidence: 99%

Section: Diagnosis Of Pulmonary Embolism With Q-only Spect Computed T...mentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic importance of lung perfusion/ventilation scans in the evaluation of pulmonary embolism in COVID-19 patients: systematic review of the literature

Rahmanipour

Ghorbani

Sadeghi

et al. 2022

Nuclear Medicine Communications

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show abstract

“…Several studies have reported mismatched perfusion defects in early–post-COVID-19 patients, which may reflect a thromboembolic process ( Klok et al, 2020 ; Mueller-Peltzer et al, 2020 ; Roncon et al, 2020 ; Idilman et al, 2021 ; Mandal et al, 2021 ; Sajal et al, 2021 ). As hinted above, widespread microthrombi have been reported in multiple organ systems in patients with COVID-19.…”

Section: Pathobiology Of Pulmonary Vascular Diseases In Sars-cov-2mentioning

confidence: 99%

From acute SARS-CoV-2 infection to pulmonary hypertension

2022

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As the world progressively recovers from the acute stages of the coronavirus disease 2019 (COVID-19) pandemic, we may be facing new challenges regarding the long-term consequences of COVID-19. Accumulating evidence suggests that pulmonary vascular thickening may be specifically associated with COVID-19, implying a potential tropism of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus for the pulmonary vasculature. Genetic alterations that may influence the severity of COVID-19 are similar to genetic drivers of pulmonary arterial hypertension. The pathobiology of the COVID-19-induced pulmonary vasculopathy shares many features (such as medial hypertrophy and smooth muscle cell proliferation) with that of pulmonary arterial hypertension. In addition, the presence of microthrombi in the lung vessels of individuals with COVID-19 during the acute phase, may predispose these subjects to the development of chronic thromboembolic pulmonary hypertension. These similarities raise the intriguing question of whether pulmonary hypertension (PH) may be a long-term sequela of SARS-COV-2 infection. Accumulating evidence indeed support the notion that SARS-COV-2 infection is indeed a risk factor for persistent pulmonary vascular defects and subsequent PH development, and this could become a major public health issue in the future given the large number of individuals infected by SARS-COV-2 worldwide. Long-term studies assessing the risk of developing chronic pulmonary vascular lesions following COVID-19 infection is of great interest for both basic and clinical research and may inform on the best long-term management of survivors.

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Longitudinal analysis of chest Q-SPECT/CT in patients with severe COVID-19

Piskac Zivkovic,

Mutvar,

Kuster

et al. 2023

Respiratory Medicine

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Lung Perfusion Scintigraphy Early After COVID-19: A Single-Center Retrospective Study

Abstract: SD: conceived the study, interpretation of data, and writing the manuscript.MR, TL, RTG, DS: Data collection and interpretation of results. All authors read and approved the final manuscript.

Cited by 8 publications

References 18 publications

Diagnostic importance of lung perfusion/ventilation scans in the evaluation of pulmonary embolism in COVID-19 patients: systematic review of the literature

Diagnostic importance of lung perfusion/ventilation scans in the evaluation of pulmonary embolism in COVID-19 patients: systematic review of the literature

From acute SARS-CoV-2 infection to pulmonary hypertension

Longitudinal analysis of chest Q-SPECT/CT in patients with severe COVID-19

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