Lung NETs and GEPNETs: One Cancer with Different Origins or Two Distinct Cancers?
Georgios Evangelou,
Ioannis Vamvakaris,
Anastasia Papafili
et al.
Abstract:Lung neuroendocrine tumors (LNETs) and gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are two distinct types of neuroendocrine tumors (NETs) that have traditionally been treated as a single entity despite originating from different sources. Although they share certain phenotypic characteristics and the expression of neuroendocrine markers, they exhibit differences in their microenvironment, molecular mutations, and responses to various therapeutic regimens. Recent research has explored the genetic alt… Show more
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