Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT)

Yan, Changqing; Tan, Xiangliang; Wei, Qi; Feng, Ru; Li, Caixia; Wu, Yuankui; Peng, Hao; Chan, Queenie; Xiong, Wei; Xu, Jun; Xu, Yu

doi:10.1007/s00330-014-3432-2

Cited by 25 publications

(14 citation statements)

References 22 publications

(23 reference statements)

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“…In a study by Attenberger et al (18), pulmonary abnormalities were detected with a sensitivity of 82.3%, specificity of 78.6%, and an overall accuracy of 88% in neutropenic patients with AML using 3.0 T MRI. In another study performed with 3.0 T MRI, pulmonary lesions were detected with a high accuracy compared with MDCT in patients with invasive fungal infection (20). In the current study, CT slices were taken at a thickness of 1.25 mm, and evaluations were performed using three separate MRI sequences.…”

Section: Discussionmentioning

confidence: 90%

MRI of pneumonia in immunocompromised patients: comparison with CT

Ekinci

Uçarkuş²,

Okur³

et al. 2017

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 90%

MRI of pneumonia in immunocompromised patients: comparison with CT

Ekinci

Uçarkuş²,

Okur³

et al. 2017

Diagn Interv Radiol

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“…In a recent study, Yan et al. found that the overall lesion‐related sensitivity of 3‐Tesla MRI was superior to that of HRCT (90.5% vs 86.9%) in detecting invasive fungal lung infection. However, Blum et al.…”

Section: Discussionmentioning

confidence: 99%

“…Our study was designed to evaluate MRI performance to investigate pulmonary fungal diseases, compared to high-resolution CT. In a recent study, Yan et al [18] found that the overall lesion-related sensitivity of 3-Tesla MRI was superior to that of HRCT (90.5% vs 86.9%) in detecting invasive fungal lung infection. However, Blum et al [19] reported that MRI was less sensitive than HRCT in the detection of initial signs of angioinvasive aspergillosis (ie halo sign).…”

Section: Discussionmentioning

confidence: 99%

Performance of magnetic resonance imaging in pulmonary fungal disease compared to high‐resolution computed tomography

Sartori¹,

Souza

Zanon

et al. 2017

Mycoses

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To evaluate the performance of magnetic resonance imaging (MRI) compared to computed tomography (CT) in patients diagnosed with pulmonary mycosis. We prospectively included 21 patients diagnosed with pulmonary mycosis between January 2013 and October 2014. Inclusion criteria were presence of respiratory symptoms, histopathological diagnosis of mycosis and absence of mycosis treatment. Reviewers identified one predominant imaging pattern per patient: nodular, reticular or airspace pattern. Afterwards, all CT findings were analysed separately per lobe and compared to MRI. Nodular pattern was the most common found (CT: 76.20%; MRI: 80.96%), followed by airspace pattern (CT and MRI: 9.52%) and reticular (CT: 9.52%; MRI: 4.76%). Compared to CT, MRI performance varied according to radiological finding and pulmonary region. For nodules, MRI presented high sensitivity (100% [95% CI: 93.52-100]) and specificity (100% [95% CI: 92.00-100]). For bronchiectasis and septal thickening, there were poorer positive predictive values (33.33% [95% CI: 1.77-87.47]; and 83.33% [95% CI: 50.88-97.06] respectively). As specificity and negative predictive value had superior results than sensitivity and positive predictive value, rather than for diagnosis of this condition, MRI might be more considered for the follow-up of patients with pulmonary mycosis, an alternative to multiple radiation exposures with CT follow-up.

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“…Ozcan et al demonstrated that using a radial acquisition method (i.e., BLADE sequence) a higher sensitivity for nodules, ground-glass opacities and consolidation, compared to half-Fourier acquisition single-shot turbo spin-echo, volumetric interpolated breath-hold examination and Fast low angle shot magnetic resonance imaging [140] can be achieved and spectral adiabatic inversion recovery and high resolution isotropic volume examination after contrast are suitable for the evaluation of invasive fungal infection [141]. Moreover, other useful tools such as intravoxel incoherent motion-derived parameters and apparent diffusion coefficient, can be applied for diagnostic purposes, allowing for example the prediction of the treatment response to fungal infection [142].…”

Section: Magnetic Resonance Imaging (Mri) and Pet/mrimentioning

confidence: 99%

Molecular Imaging of Pulmonary Inflammation and Infection

Giraudo

Evangelista

Fraia

et al. 2020

IJMS

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Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and mortality worldwide. Although infrequently used in this setting, molecular imaging may significantly contribute to their diagnosis using techniques like single photon emission tomography (SPET), positron emission tomography (PET) with computed tomography (CT) or magnetic resonance imaging (MRI) with the support of specific or unspecific radiopharmaceutical agents. 18F-Fluorodeoxyglucose (18F-FDG), mostly applied in oncological imaging, can also detect cells actively involved in infectious and inflammatory conditions, even if with a low specificity. SPET with nonspecific (e.g., 67Gallium-citrate (67Ga citrate)) and specific tracers (e.g., white blood cells radiolabeled with 111Indium-oxine (111In) or 99mTechnetium (99mTc)) showed interesting results for many inflammatory lung diseases. However, 67Ga citrate is unfavorable by a radioprotection point of view while radiolabeled white blood cells scan implies complex laboratory settings and labeling procedures. Radiolabeled antibiotics (e.g., ciprofloxacin) have been recently tested, although they seem to be quite unspecific and cause antibiotic resistance. New radiolabeled agents like antimicrobic peptides, binding to bacterial cell membranes, seem very promising. Thus, the aim of this narrative review is to provide a comprehensive overview about techniques, including PET/MRI, and tracers that can guide the clinicians in the appropriate diagnostic pathway of infectious and inflammatory pulmonary diseases.

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Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT)

Cited by 25 publications

References 22 publications

MRI of pneumonia in immunocompromised patients: comparison with CT

MRI of pneumonia in immunocompromised patients: comparison with CT

Performance of magnetic resonance imaging in pulmonary fungal disease compared to high‐resolution computed tomography

Molecular Imaging of Pulmonary Inflammation and Infection

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