Lung Morphology Assessment with Balanced Steady-State Free Precession MR Imaging Compared with CT

Rajaram, Smitha; Swift, Andrew J.; Capener, David; Telfer, Adam; Davies, Christine; Hill, Catherine; Condliffe, Robin; Elliot, Charles; Hurdman, Judith; Kiely, David; Wild, Jim M.

doi:10.1148/radiol.12110990

Cited by 51 publications

(38 citation statements)

References 34 publications

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“…Second, we confirmed that trapped air could not be reliably visualised with MRI, as previously demonstrated by Failo et al and more recently by Rajaram et al [14,15]. Trapped air is an early change associated with small airways disease [3,23].…”

Section: Discussionsupporting

confidence: 83%

“…Magnetic resonance imaging (MRI), as a radiation-free technique, has been introduced as an alternative to CT [11,12]. To date, MRI has been directly compared to CT in only a few studies, using various MRI sequences [13][14][15], but none of those included motion correction free-breathing sequences, such as PROPELLER. The PROPELLER sequence has been designed to be relatively insensitive to respiratory movements, as it enables correction of in-plane motion, rotation and translation [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

et al. 2015

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

et al. 2015

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“…It would be interesting to apply this approach to the lungs using our technique. A further application is the potential ability to assist in differentiating fibrosis from mimickers such as emphysema (1,6). We know this can be challenging even for expert readers (1,6).…”

Section: Discussionmentioning

confidence: 99%

“…A further application is the potential ability to assist in differentiating fibrosis from mimickers such as emphysema (1,6). We know this can be challenging even for expert readers (1,6). This might be of particular value in patients with combined pulmonary emphysema-fibrosis syndrome, to evaluate the percentage of abnormal lung that is fibrotic (28).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT

Lavelle

Brady²,

McEvoy³

et al. 2017

Diagn Interv Radiol

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“…The quality of proton structural MRI of the lungs has improved in recent years through the use of MR sequences such as ultra-short echo time (Lederlin and Crémillieux, 2013) and balanced steady state free precession (Rajaram et al, 2012) to the point where the scans have diagnostic utility in certain conditions.…”

Section: Introductionmentioning

confidence: 99%

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI

et al. 2014

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This is a repository copy of ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid Short Title Hyperpolarised gas MRI and CT image registration AbstractHyperpolarized gas MRI generates highly detailed maps of lung ventilation and physiological function while CT provides corresponding anatomical and structural information. Fusion of such complementary images enables quantitative analysis of pulmonary structure-function. However, direct image registration of hyperpolarized gas MRI to CT is problematic, particularly in lungs whose boundaries are difficult to delineate due to ventilation heterogeneity. This study presents a novel indirect method of registering hyperpolarized gas MRI to CT utilizing 1 H-structural MR images that are acquired in the same breath-hold as the gas MRI. The feasibility of using this technique for regional quantification of ventilation of specific pulmonary structures is demonstrated for the lobes.The direct and indirect methods of hyperpolarized gas MRI to CT image registration were compared using lung images from 15 asthma patients. Both affine and diffeomorphic image transformations were implemented. Registration accuracy was evaluated using the target registration error (TRE) of anatomical landmarks identified on 1 H MRI and CT. Wilcoxon signed-rank test was used to test statistical significance.For the affine transformation, the indirect method of image registration was significantly more accurate than the direct method (TRE=14.7±3.2 vs. 19.6±12.7mm, p=0.036). Using a deformable transformation, the indirect method was also more accurate than the direct method (TRE=13.5±3.3 vs. 20.4±12.8mm, p=0.006).Accurate image registration is critical for quantification of regional lung ventilation with hyperpolarized gas MRI within the anatomy delineated by CT. Automatic deformable image registration of hyperpolarized gas MRI to CT via same breath-hold 1 H MRI is more accurate than direct registration. Potential applications include improved multi-modality image fusion, functionally-weighted radiotherapy planning, and quantification of lobar ventilation in obstructive airways disease.

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Lung Morphology Assessment with Balanced Steady-State Free Precession MR Imaging Compared with CT

Cited by 51 publications

References 34 publications

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI

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Lung Morphology Assessment with Balanced Steady-State Free Precession MR Imaging Compared with CT

Cited by 51 publications

References 34 publications

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/1H MRI

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A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI