Lung Microvascular Niche, Repair, and Engineering

Tsuchiya, Tomoshi; Doi, Ryoichiro; Obata, Tomohiro; Hatachi, Go; Nagayasu, Takeshi

doi:10.3389/fbioe.2020.00105

Cited by 33 publications

(22 citation statements)

References 138 publications

(219 reference statements)

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“…Other mechanical requirements for ATES devices include tolerance to tension in applications such as nerve repair ( Du et al, 2018 ), and to compression in cartilage and bone regeneration ( Serpooshan et al, 2010 , 2013a ). Further, flexibility and elasticity of the scaffold are prominent in applications for lung and gastrointestinal adhesion ( Tsuchiya et al, 2020 ). Also, harsh conditions in diseased states or post-surgery should be taken into account for in vivo applications ( Zaokari et al, 2020 ).…”

Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Chen

Gil

Ning

et al. 2021

Front. Bioeng. Biotechnol.

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A variety of suture and bioglue techniques are conventionally used to secure engineered scaffold systems onto the target tissues. These techniques, however, confront several obstacles including secondary damages, cytotoxicity, insufficient adhesion strength, improper degradation rate, and possible allergic reactions. Adhesive tissue engineering scaffolds (ATESs) can circumvent these limitations by introducing their intrinsic tissue adhesion ability. This article highlights the significance of ATESs, reviews their key characteristics and requirements, and explores various mechanisms of action to secure the scaffold onto the tissue. We discuss the current applications of advanced ATES products in various fields of tissue engineering, together with some of the key challenges for each specific field. Strategies for qualitative and quantitative assessment of adhesive properties of scaffolds are presented. Furthermore, we highlight the future prospective in the development of advanced ATES systems for regenerative medicine therapies.

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Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Chen

Gil

Ning

et al. 2021

Front. Bioeng. Biotechnol.

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“…However, TE is now reaching a new level of complexity: two-dimensional cell monolayers are moving to three-dimensional constructs (or even to four-dimensional ones) [131][132][133]. Cell lines are being replaced by pluripotent and patient-derived cells [134][135][136], and tissue grafts are evolving to organoids and whole organs [10,16,47,[136][137][138][139][140][141]. As such, the materials employed must improve accordingly.…”

Section: Sbps For Tissue Engineering (Te)mentioning

confidence: 99%

Supramolecular Biopolymers for Tissue Engineering

Pérez-Pedroza

Ávila-Ramírez

Khan

et al. 2021

Advances in Polymer Technology

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Supramolecular biopolymers (SBPs) are those polymeric units derived from macromolecules that can assemble with each other by noncovalent interactions. Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the generation of sequence-specific supramolecular units like SBPs that can be tailored for novel applications in tissue engineering (TE). SBPs hold advantages over other conventional polymers previously used for TE; these materials can be easily functionalized; they are self-healing, biodegradable, stimuli-responsive, and nonimmunogenic. These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. In this review, we will analyse the 3 subtypes of SBPs: peptide-, nucleic acid-, and oligosaccharide-derived. Then, we will discuss the role that SBPs will be playing in TE as dynamic scaffolds, therapeutic scaffolds, and bioinks. Finally, we will describe possible outlooks of SBPs for TE.

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“…The cells are placed inside the scaffold and cultured in a bioreactor. When the patient's cells are placed in the biomaterials and used in affected lung tissue this will make the lung compatible to targeted immune system and cures the damage caused by infection (Tsuchiya et al, 2020). Recently, a human lung culture model was made from the human lung cells which is used to study the infections caused to lungs such as SARS COV -2 (Salahudeen et al, 2020).…”

Section: Tissue Engineering In Lungsmentioning

confidence: 99%

Feasibility of nano-scaffold for Covid-19 infected lung tissue regeneration: A review

Jeevika¹,

Sobiya²,

Indhumathi³

et al. 2021

Asian J Pharm Pharmacol

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In December 2019, a cluster of cases of pneumonia of unknown origin was identified in Wuhan, China which was named as SARS-CoV-2 by the International Committee on Taxonomy of Viruses. The Covid-19 attacks the respiratory system of the infected people leading to its severe damage by eliciting a vigorous immune response by our body. The disease has spread worldwide and affects human health. Covid-19, a newly reported virus is 96% similar to bat CoV. Upon inhalation, the virus enters the respiratory region by unlocking ACE2 protein. Type 2 alveolar cell leading to collapse of alveolus which leads to fluid accumulation, it causes ARDS, SIRS, multi organ failure which cause fatal consequences. In this review, the scope of nanoscaffold in the Covid-19 infected lung tissue regeneration was discussed. Tissue engineering and nanotechnology can help in formation of tissue and guide cellular activities. Damaged tissue can be regenerated by nanoscaffolds that have potential to be risk-free, antiviral and also biological therapeutics. Scaffolds provide intra and extracellular cell contact in regenerative medicine and can provide mechanical strength, oxygen and nutrients for cell metabolism, cell adhesion, and progressive maturation and remove metabolic waste products. It also has some limitations like short circulation half-life of bioactive molecules,inadequate extrinsic factors, variable toxicity, poor regulation and degradation rate. These nanoscaffolds for lung tissue damage due to Covid-19 improve adsorption of ECM protein, new tissue formation, and enhance biological regulation of cell behavior for regeneration and help to recover from lung damage.

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Lung Microvascular Niche, Repair, and Engineering

Cited by 33 publications

References 138 publications

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Supramolecular Biopolymers for Tissue Engineering

Feasibility of nano-scaffold for Covid-19 infected lung tissue regeneration: A review

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