Lung metastases from colorectal cancer: surgical resection and prognostic factors☆

Rama, N.; Monteiro, Alexandre; Bernardo, João; Eugénio, Luís; Antunes, Manuel J.

doi:10.1016/j.ejcts.2008.10.047

Cited by 102 publications

(87 citation statements)

References 23 publications

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“…Полное циторедуктивное хирургическое лечение -единственный метод, дающий пациентам шанс на долгосрочную выживаемость. Доля таких больных в нашей работе невелика, а актуариальная 3-летняя ОВ составляет 60 % по сравнению с 37-68 % по данным зарубежных публикаций [15,[18][19][20][21][22].…”

Section: Discussionunclassified

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Расулов¹,

Давыдов²,

Алиев³

et al. 2016

Onkol. koloproktol.

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Section: Discussionunclassified

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Расулов¹,

Давыдов²,

Алиев³

et al. 2016

Onkol. koloproktol.

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“…These include histopathological grade of the primary tumor, 20,21 time to RFA treatment (pulmonary disease-free interval), [22][23][24] repeat RFA treatments, 25 and the presence of mediastinal lymphadenopathy. 20,26,27 Specific to the current study, the absence of extrapulmonary metastases Figure 2.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases

Chua

Thornbury

Saxena

et al. 2010

Cancer

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BACKGROUND: Radiofrequency ablation (RFA) is an alternative to local treatment for pulmonary metastases in patients who are nonsurgical candidates. Based on previously documented efficacy of this treatment, the authors retrospectively studied the prognostic factors for long-term survival. METHODS: One hundred patients with unresectable colorectal pulmonary metastases underwent percutaneous RFA. Clinical and treatment variables were collected and evaluated using univariate and multivariate analyses with overall survival as the primary endpoint. RESULTS: At a median follow-up period of 23 (range, 1 to 96) months from the time of RFA treatment, 49 patients have died. The median overall survival after RFA treatment was 36 months and 5-year overall survival rates of 30%. Univariate analyses demonstrated that histopathological grade (p < .001), time to RFA treatment (p ¼ .017), response to treatment (p < .001), repeat RFA treatments (p ¼ .001), presence of extrapulmonary metastases (p < .001), presence of mediastinal lymphadenopathy (p ¼ .007), and adjunct systemic chemotherapy (p < .001) were associated with overall survival. Multivariate analyses demonstrated that response to RFA treatment (p < .001), repeat RFA treatment (p ¼ .002), presence of extrapulmonary metastases (p ¼ .008), and use of adjunct systemic chemotherapy (p ¼ .05) were independent predictors for survival. CONCLUSIONS: Radiofrequency ablation for colorectal pulmonary metastases represents a step forward towards a nonsurgical option of combining systemic and local treatment for metastatic disease and is a safe treatment with a low risk profile.

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“…The level of CEA in serum before thoracotomy is one of the most significant prognostic factors in univariate and multivariate analysis for survival after resection of metastatic tumors of the lungs (15,17,50,64,65). As a whole the increased serum level of CEA is related with the biologic functions of the colorectal carcinoma because its increased expression correlates with bad prognosis not only with organ localization but with its metastatic progression in the lungs (50,64).…”

Section: Tumor Markers -Carcinoembrionic Antigen (сеа) -mentioning

confidence: 99%

“…N. Rama at al. (17) registered that the lung metastases predominate when the localization is in lower and medium third of the rectum, in 36% and 39% respectively versus the rest 25% of the patients with localization in the upper third of the rectum. W. Takahashi et al (1) report that after total removal and treatment of the patients with colorectal carcinoma pulmonary progression is registered approximately in 10%.…”

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confidence: 99%

Diagnostics of intrapulmonary metastases from colorectal cancer (literature survey)

Obretenov¹,

Georgieva²

2015

TJS

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The colon cancer is on the first place as etiologic cause for performing pulmonary resection due to pulmonary metastases. The low effectiveness of chemotherapy in case of metastatic progression from colorectal carcinoma is established. Accordingly, the surgical resection is commonly accepted as the only potential therapeutic option. In favour of the good results from surgical treatment is the trend of earlier finding of pulmonary metastases. The metastases diagnostics has important meaning for differentiation from other lung diseases and for the choice of the therapeutic method. The benefits and disadvantages of non-invasive (chest X-ray, CT, lung perfusion scintigraphy, PET and PET/CT, tumor markers) and invasive (bronchoscopy, mediastinoscopy, VATS (video-assisted thoracic surgery, TTNB (trans-thoracic needle biopsy)) methods for diagnosis of intrapulmonary metastases are analyzed. Key words: colorectal cancer, pulmonary metastasesThere are different reports in the scientific literature about the incidence of colorectal carcinoma. According to some authors it is the third most often diagnosed cancer in the world (1-4). The data from P. J Villeneuve and R. S. Sundaresan (5) show that over one million new patients get sick from this insidious disease every year. H. Meulendeld at al. (6) report that 40% of the patients with colorectal carcinoma in Europe are over 75 years of age at the moment of first diagnosis and there are expectations that this number would significantly increase in the next two decades.The colorectal carcinoma in Bulgaria according to the data from 2012 for prevalence is on third place in men and on second place in women and represents 8.6% from all malignant diseases totally for both sexes. The registered new cases are 2772, and 52,7% of them in men. The diagnosis in 42,4% of the patients is set in advanced III and IV stages. The relative 5 -year survival in Bulgaria is 45,0% for men, 45,3% for women and 45,2% totally for both sexes. It is lower than the average for Europe-55,6%. (7). According to summed statistics A. ___________________________

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Lung metastases from colorectal cancer: surgical resection and prognostic factors☆

Cited by 102 publications

References 23 publications

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases

Diagnostics of intrapulmonary metastases from colorectal cancer (literature survey)

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