Cardiopulmonary bypass surgery has been implicated in causing atelectasis; a major cause of intrapulmonary shunting and hypoxemia postoperatively. This study investigated if repetitive lung recruitment manoeuvres (RRM), before and after extubation, could reduce intrapulmonary shunting for a longer period post-extubation than only one standardized recruitment manoeuvre (SRM), Forty cardiac valve replacement patients were randomised after SRM into two groups: RRM group (n=20): Total vital capacity manoeuvre at surgery end and repeated every 4 hours until extubation; SC group (n=20): Standard care with SRM. Intrapulmonary shunts (Qs/Qt) were measured after anaesthesia induction, at surgery termination and every 4 hours until 24 hours post-extubation. Time to extubation was recorded. Lung function was measured every 12 hours until discharge.A 24 hour post-extubation ANOVA showed no Qs/Qt significant differences between RRM and SC group (4.5 ± 3.3% and 5.3 ± 2.4%). At surgery end, Qs/Qt increased in RRM group (7.3 ± 3.2% to 13.5 ± 3.7%; p<10-3) but was significantly less (p<0.02) compared to SC group (7.3 ± 3.7% to 16.1 ± 6%; p<10-3). Time to extubation was 8.8 ± 4.2 h in RRM group versus 10.4 ± 4.3 h SC group (p<0.2, ns). No significant difference in vital capacity was seen in the RRM group (3.17 ± 1.2 to 1.9 ± 1 l) compared to SC group (3.4 ± 0.8 to 2.1 ± 0.9 l).In valve replacement surgery, RRM is only beneficial in the short-term period and does not assure a better intrapulmonary shunt benefit than one SRM applied at the end of surgery.