Lung inflammation in the pathogenesis of rheumatoid arthritis

Demoruelle, M. Kristen; Wilson, Timothy M.; Deane, Kevin D.

doi:10.1111/imr.12842

Cited by 18 publications

(19 citation statements)

References 103 publications

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“…Our findings suggest that early-life inhaled exposures such as passive cigarette smoking could predispose individuals to develop RA not explained by later personal smoking behaviors. These results add to the mucosal paradigm of RA pathogenesis (5)(6)(7), where inhalants in pulmonary mucosa may trigger biologic processes that contribute to RA-related autoantibody production years before clinical RA symptoms emerge. Personal smoking is one of the most well-established modifiable risk factors for incident RA, whereas the influence of passive smoking is less well understood (14).…”

Section: Discussionmentioning

confidence: 67%

“…Rheumatoid arthritis (RA) is a debilitating systemic inflammatory disease characterized by prominent polyarthritis with associated morbidity and mortality (1)(2)(3). In its pathogenesis, considered an interplay of genetic and environmental exposures (4), lung inflammation is strongly implicated as an initial site of immune dysregulation and RA-related autoantibody production (5)(6)(7). Thus, smoking, personal (active) and passive, has been of interest as a major modifiable environmental risk factor for seropositive RA, which is characterized…”

Section: Introductionmentioning

confidence: 99%

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Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women

Yoshida

Wang

Malspeis

et al. 2021

Arthritis & Rheumatology

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Objective. To investigate passive smoking throughout the life course and the risk of rheumatoid arthritis (RA), while accounting for personal smoking.Methods. We analyzed the Nurses' Health Study II prospective cohort, using information collected via biennial questionnaires. We assessed the influence of 1) maternal smoking during pregnancy (in utero exposure), 2) childhood parental smoking, and 3) years lived with smokers since age 18. Incident RA and serostatus were determined by medical record review. Using the marginal structural model framework, we estimated the controlled direct effect of each passive smoking exposure on adult incident RA risk by serologic phenotype, controlling for early-life factors and time-updated adulthood factors including personal smoking.Results. Among 90,923 women, we identified 532 incident RA cases (66% seropositive) during a median of 27.7 years of follow-up. Maternal smoking during pregnancy was associated with RA after adjustment for confounders, with a hazard ratio (HR) of 1.25 (95% confidence interval [95% CI] 1.03-1.52), but not after accounting for subsequent smoking exposures. Childhood parental smoking was associated with seropositive RA after adjustment for confounders ). In the controlled direct effect analyses, childhood parental smoking was associated with seropositive RA (HR 1.75 [95% CI 1.03-2.98]) after controlling for adulthood personal smoking, and the association was accentuated among ever smokers ). There was no significant association of adulthood passive smoking with RA (HR 1.30 for ≥20 years of living with a smoker versus none [95% CI 0.97-1.74]).Conclusion. We found a potential direct influence of childhood parental smoking on adult-onset incident seropositive RA even after controlling for adulthood personal smoking.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women

Yoshida

Wang

Malspeis

et al. 2021

Arthritis & Rheumatology

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“…Pulmonary lesions, as well as vascular, airway, pleural and parenchymal diseases, appear in approximately 70% of patients with RA 23 . RA‐related pulmonary diseases involving the airways such as COPD, asthma, bronchiectasis, and cricoarytenoid arthritis, are known to be frequent, but interstitial lung disease (ILD), a parenchymal disease, is also common, and it has been reported that up to 58% of RA patients have ILD 24 .…”

Section: Discussionmentioning

confidence: 99%

“…These pulmonary diseases are caused by various genetic and environmental factors and usually share a common risk factor smoking. In addition, they have similar respiratory symptoms, and when the disease progresses, both obstructive and restrictive patterns appear simultaneously on PFT appear 23,26 . Therefore, in this study, pulmonary diseases other than COPD having mixed pattern on PFT may be included; further investigations such as radiological findings may be used to distinguish pulmonary diseases more accurately.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: A cross‐sectional study

et al. 2021

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Objective Rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD) are both chronic inflammatory diseases; the prevalence of COPD in RA patients is known to be high. However, the prevalence of both RA and COPD differs according to sex; the relationship between RA and COPD may also vary according to sex. Therefore, we investigated the prevalence of COPD and its association in patients with RA in Korea by sex. Methods We conducted a nationwide cross‐sectional study using data from the Korea National Health and Nutrition Examination Survey. A total of 12 417 men and 15 878 women were included. In this study, RA was defined as physician diagnosed or currently under RA treatment. COPD was defined based on spirometry results, chronic symptoms, and smoking history. Multivariable logistic regression models were employed and we calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for COPD prevalence in patients with RA. Results The prevalence of COPD was 15.5% in men with RA, 3.5% in women with RA, 7.8% in men without RA, and 2.2% in women without RA. After adjustment for potential confounding variables, including smoking status, RA was significantly associated with COPD in men (OR 2.16, 95% CI 1.06‐4.40), but not in women (OR 1.58, 95% CI 0.81‐3.10). Conclusions In Korea, the prevalence of COPD was high in patients with RA of both sexes; RA and COPD was significantly likely to be associated in men, but not in women.

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“…When one or more of these autoantibodies are detected in serum, RA is defined seropositive (RA+) and the disease might manifest with more severe symptoms such as erosive joint degeneration and rapid radiographic progression [1,6].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-analysis on the Association of Occupational Exposure to Free Crystalline Silica and Rheumatoid Arthritis

Morotti

Sollaku

Franceschini

et al. 2021

Clinic Rev Allerg Immunol

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Key messages • Occupational exposure to free crystalline silica and tobacco smoking are associated with an increased risk rheumatoid arthritis, with the evidence of an interaction in seropositive subjects. • Further studies in the field are needed to support such association We carried out a systematic search for all published epidemiological studies concerning the association between occupational exposure to free crystalline silica (FCS) and subsequent development of rheumatoid arthritis (RA). A meta-analysis was conducted on relevant studies. We searched PubMed and Embase, search engines, for original articles published (from 1960 to November 2019) in any language. In addition, we also searched reference lists of included studies manually for additional relevant articles. Finally, twelve studies were included in the meta-analysis (seven case-control cases and five cohort studies). The odds risks and 95% confidence interval (CI) were calculated using a random effect meta-analysis. A primary meta-analysis (using a random effect model)—regarding RA risk in subjects exposed to FCS—yelled to an overall OR of 1.94 (95% CI 1.46–2.58). We also conducted three further meta-analysis, taking into account the presence of autoantibodies (anti-RF or anti-ACPA) and smoking habits and found a significant association between FCS and RA in both seropositive and seronegative subjects (OR 1.74, 95% CI 1.35–2.25 and OR 1.23, 95% CI 1.06–1.4, respectively) and in seropositive subjects which were smokers (OR 3.30, 95% CI 2.40–4.54). The studies that have investigated the association between RA and occupatational exposure to FCS are still scarce and the heterogeneity between the studies remains high. Some critical limitations have been identified within studies, among which, the methods for assessing exposure stand out. Although with due caution, our results confirm the hypothesis of an association between occupational exposure to FCS and RA development. There was an interaction between FCS and tobacco smoking in RA seropositive workers.

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Lung inflammation in the pathogenesis of rheumatoid arthritis

Cited by 18 publications

References 103 publications

Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women

Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women

Prevalence of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: A cross‐sectional study

Systematic Review and Meta-analysis on the Association of Occupational Exposure to Free Crystalline Silica and Rheumatoid Arthritis

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