Lung Function, Respiratory Symptoms, and Mortality

Knuiman, Matthew; James, Alan; Divitini, Mark; Ryan, Gerard; Bartholomew, Helen C.; Musk, Arthur W.

doi:10.1016/s1047-2797(98)00066-0

Cited by 138 publications

(113 citation statements)

References 31 publications

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“…In American and European populations, FEV 1 /FVC ratio and mortality often present significant relationships (2,(12)(13)(14), but in this study, we found no such relationship. This could be related to ratio and mortality differences, in addition to various anthropo-biological, social and cultural differences between Japanese and non-Japanese population.…”

Section: Discussioncontrasting

confidence: 83%

“…Impaired lung function is a significant predictor of mortality (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd.…”

Section: Introductionmentioning

confidence: 99%

“…However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd. (1,2,8).…”

Section: Introductionmentioning

confidence: 99%

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Nested case-control study on associations between lung function, smoking and mortality in Japanese population

Sekine

Gaina

et al. 2007

Environ Health Prev Med

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Objectives: Only a few long-term follow-up studies with a focus on the association between lung function and mortality in the Japanese population have been undertaken. In this study, we examined the associations of lung function, smoking and the results of allergy skin tests with mortality in a longitudinal study of the Japanese population.Methods: Baseline measurements were performed on residents of Fukui, Japan in 1972, and a follow-up survey was conducted in 2002. By employing a nested case-control design, 596 cases (deaths) and 596 age and sex-matched controls (survivals) were selected. Lung function was assessed using forced vital capacity (FVC) expressed as the normal percent predicted (FVC %pred) and the ratio of forced expiratory volume in 1 second (FEV 1 ) to FVC (FEV 1 /FVC). Allergy skin tests were performed with extracts of house dust, candidia and mixed fungal samples (bronchomycosis). The Brinkman index was used to assess smoking intensity. The Cox proportional hazards model was used to evaluate whether lung function was associated with mortality after adjustment for other potential confounding variables.Results: Those categorized into the first-or second-lowest quartile of FVC %pred had a higher mortality [hazard ratios (HRs) and 95% confidence intervals (CIs): 2.01 (1.26−3.19) and 1.84 (1.11− 3.05)], respectively. On top of these, heavy smoking (BI≥400) was associated with a higher mortality [HR and 95%CI: 1.73 (1.18−2.53)]. There were only weak of associations between the results of allergy skin tests and mortality.Conclusions: These results suggest that FVC %pred of lung function and smoking can serve as long-term independent predictors of mortality.

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Nested case-control study on associations between lung function, smoking and mortality in Japanese population

Sekine

Gaina

et al. 2007

Environ Health Prev Med

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“…25 Lower levels of pulmonary function were also related to increased all-cause mortality, similar to findings observed in the ablebodied. [26][27][28] These observations illustrate with aging, factors that influence mortality in the able-bodied also are the most important factors influencing mortality in SCI. Owing to the relatively small numbers of deaths, our results are too imprecise to assess whether mortality due to heart disease and diabetes in this study is greater in SCI than in the able-bodied.…”

Section: Discussionmentioning

confidence: 75%

A prospective assessment of mortality in chronic spinal cord injury

et al. 2005

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Study design: Prospective mortality study. Objective: To assess the relationship between comorbid medical conditions and other healthrelated factors to mortality in chronic spinal cord injury (SCI). Setting: Boston, MA, USA. Methods: Between 1994 and 2000, 361 males X1 year after injury completed a respiratory health questionnaire and underwent pulmonary function testing. Cause-specific mortality was assessed over a median of 55.6 months (range 0.33-74.4 months) through 12/31/2000 using the National Death Index. Results: At entry, mean (7SD) age was 50.6715.0 years (range 23-87) and years since injury was 17.5712.8 years (range 1.0-56.5). Mortality was elevated (observed/expected deaths ¼ 37/ 25.1; SMR ¼ 1.47; 95% CI ¼ 1.04-2.03) compared to US rates. Risk factors for death were diabetes (RR ¼ 2.62; 95% CI ¼ 1.19-5.77), heart disease (RR ¼ 3.66; 95% CI ¼ 1.77-7.78), reduced pulmonary function, and smoking. The most common underlying and contributing causes of death were diseases of the circulatory system (ICD-9 390-459) in 40%, and of the respiratory system in 24% (ICD-9 460-519). Conclusions: These results suggest that much of the excess mortality in chronic SCI is related to potentially treatable factors. Recognition and treatment of cardiovascular disease, diabetes, and lung disease, together with smoking cessation may substantially reduce mortality in chronic SCI.Spinal Cord (2005) 43, 408-416.

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“…The level of lung function is one of the most consistent and long-known predictors of survival (Burney and Hooper 2011;Knuiman et al 1999;Schunemann et al 2000). Lung function naturally starts to decline at the age of 30 years (Quanjer et al 2012), and accelerated decline in adult life was repeatedly associated with increased mortality, not only due to cardiovascular and respiratory disease (Tockman et al 1995) which could be attributable to smoking but also with all-cause mortality and in never smokers (Mannino et al 2006;Ryan et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline

Ivan

Imboden

Bridevaux

et al. 2016

AGE

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Lung function is an independent predictor of mortality and serves as an aging marker in never smokers. The protein sirtuin-1 of gene SIRT1 has profound anti-inflammatory effects and regulates metabolic pathways. Its suggested longevity effects on lower organisms remain poorly studied in humans. In 1132 never smokers of the population-based SAPALDIA cohort, we investigated associations between single nucleotide polymorphisms (SNPs; rs730821, rs10997868, rs10823116) of SIRT1 and aging-related lung function decline over 11 years in terms of change in forced expiratory volume in the first second (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC ratio, and forced expiratory flow between 25 and 75 % of FVC ) using multiple linear regression models. Interactions between the SIRT1 SNPs and adiposity parameters (body mass index (BMI), its change and weight gain) were tested by including multiplicative interaction terms into the models. SIRT1 polymorphisms exhibited no main effects, but modified the association between obesity measures and FEV 1 /FVC and FEF was accelerated up to −0.5 % (95 % CI −1.0 to 0 %) and −0.7 % (−1.3 to −0.2 %) over interquartile range increases in BMI (2.4 kg/m 2 ) or weight (6.5 kg), respectively. For FEF decline, corresponding estimates were −57 mL/s (−117 to 4 mL/s) and −76 mL/s (−1429 to −9 mL/s). Interactions were not present in participants with genetically lowered C-reactive protein concentrations. Genetic variation in SIRT1 might therefore affect lung function and human longevity by modifying subclinical inflammation arising from abdominal adipose tissue.

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Lung Function, Respiratory Symptoms, and Mortality

Cited by 138 publications

References 31 publications

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

A prospective assessment of mortality in chronic spinal cord injury

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline

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