Lung function predicts survival in a cohort of asbestos cement workers

Moshammer, Hanns; Neuberger, Manfred

doi:10.1007/s00420-008-0322-4

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…For example a group of workers exposed to asbestos with moderate dyspnoea had mean FVC of 96%, mean FEV 1 of 94% and mean FEV 1 /FVC of 95% of predicted [68], which are similar to our pooled estimates. In one study, lung function impairments, particularly airflow obstruction, have been associated with increased mortality in asbestos exposed workers [69]. …”

Section: Discussionmentioning

confidence: 99%

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Wilken

Garrido

Manuwald

et al. 2011

J Occup Med Toxicol

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BackgroundA continuing controversy exists about whether, asbestos exposure is associated with significant lung function impairments when major radiological abnormalities are lacking. We conducted a systematic review and meta-analysis in order to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings.MethodsMEDLINE was searched from its inception up to April 2010. We included studies that assessed lung function parameters in asbestos exposed workers and stratified subjects according to radiological findings. Estimates of VC, FEV1 and FEV1/VC with their dispersion measures were extracted and pooled.ResultsOur meta-analysis with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1/VC, even in those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies.ConclusionsAsbestos exposure is related to restrictive and obstructive lung function impairment. Even in the absence of radiological evidence of parenchymal or pleural diseases there is a trend for functional impairment.

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Section: Discussionmentioning

confidence: 99%

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Wilken

Garrido

Manuwald

et al. 2011

J Occup Med Toxicol

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“…Auch die FEF 25 -75 zeigt weitgehend unabhängig von Röntgenbefunden im Mittel leichte Einschränkungen in asbestexponierten Kollektiven. Moshammer und Neuberger [59] beschrieben zusätzlich eine signifikante Korrelation zwischen Asbestfaserdosis und FEF 75 -Abnahme (Koeffizient: -0,05; 95 % CI 0,10 -0,005). Diese vorgenannten Aussagen werden auch von Ohar et al [8] bestätigt: Die FEV 1 /FVC betrug 76,8 ± 8,9 % unter Nichtrauchern, 71,0 ± 12,3 % unter Exrauchern und 68,7 ± 12,7 % unter aktiven Rauchern (p < 0,001).…”

Section: Flussvolumenwerteunclassified

Verursacht langjährige Asbestexposition eine obstruktive Ventilationsstörung?

Baur

Manuwald²,

Wilken³

2010

Pneumologie

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“…In dem von Ohar et al [59] untersuchten Kollektiv mit großteils pleurale Veränderungen aufweisenden Untergruppen standen obstruktive Ventilationsstörungen im Vordergrund (25,4 %), gefolgt von restriktiven (19,3 %) und kombinierten (6 %). Moshammer und Neuberger [30] untersuchten 309 ehemalige Beschäftigte einer Asbestzementfabrik (davon hatten 33 pleurale Veränderungen und einige eine Asbestose) von 1989 bis zu ihrem Tod bzw. dem Ende der Studie 2006.…”

Section: Exponierte Mit Asbestbedingten Nicht Malignenunclassified

Auswirkungen der Asbestfaserstaub-Exposition auf die Lungenfunktion – ein systematisches Review

Baur¹,

Wilken²

2010

Pneumologie

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Asbestos-induced lung diseases are in addition to skin diseases and hearing impairment due to noise the most frequent occupational diseases. In this connection, many questions arise. They particularly refer to the fine diagnostics and the compensation in case of early stages. This systematic review questions the prevailing practice of getting medical expert opinions. It was shown that already pleural plaques and low stages of lung fibrosis due to asbestos are significantly associated with symptoms of chronic obstructive bronchitis, lymphocytic alveolitis and significant functional restrictions, i. e. FVC, FEV (1) and TLC restrictions, gas exchange impairments (P ((A-a),O2), P (a,O2)), diffusion disorders (D (L,CO)) and an obstructive ventilation pattern (FEV (1)/FVC, FEF values, D (L,CO)). The asbestos fibre dose shows some relation to reductions of FVC, FEV (1), FEF values, and D (L,CO). Only about half of the asbestos-induced functional impairments are related to radiological (inclusive CT) findings. To a lesser degree, these findings also apply to exposed people without pathological chest X-ray findings. The diffusion capacity reduction, at first still within the reference range, is an early indication of a lung lesion caused by asbestos fibres. The same applies to spiroergometric parameters (P ((A-a),O2), V (E/)V (O2), V (D)/V (T)). Reduced lung compliance can also be determinable at an early asbestosis stage. The results of literature research confirmed by statements of international groups of experts indicate continuous pathophysiological processes due to asbestos fibres deposited in peripheral airways and in the lung. These processes are neither radiologically nor histopathologically detectable and occur with a chronic lymphocytic alveolitis. Therefore, diagnostics of asbestos-induced non-malignant lung and pleural changes require comprehensive lung function tests. The outcome may help to estimate the probable remaining life span.

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Lung function predicts survival in a cohort of asbestos cement workers

Cited by 10 publications

References 22 publications

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Verursacht langjährige Asbestexposition eine obstruktive Ventilationsstörung?

Auswirkungen der Asbestfaserstaub-Exposition auf die Lungenfunktion – ein systematisches Review

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