Lung function in children in relation to ethnicity, physique and socioeconomic factors

Lum, Sooky; Bountziouka, Vassiliki; Sonnappa, Samatha; Wade, Angie; Cole, Tim J.; Harding, Seeromanie; Wells, Jonathan C. K.; Griffiths, Chris; Treleaven, Philip; Bonner, Rachel; Kirkby, Jane; Lee, Simon; Raywood, Emma; Legg, Sarah; Sears, Dave; Cottam, Philippa; Feyeraband, Colin; Stocks, Janet

doi:10.1183/13993003.00415-2015

Cited by 42 publications

(64 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Information on children's age (in years), sex and school attended was collected during school visits. Ethnicity data were collected via the parental questionnaire [25,26]. Children were assigned to one of three ethnic groups: black (African/Caribbean ancestry), South Asian (ancestry from the Indian subcontinent) or white/other (European/other/mixed ancestry).…”

Section: Potential Confoundersmentioning

confidence: 99%

Associations of the objective built environment along the route to school with children’s modes of commuting: A multilevel modelling analysis (the SLIC study)

Bosch

Wells

Lum³

et al. 2020

PLoS ONE

Self Cite

View full text Add to dashboard Cite

As active commuting levels continue to decline among primary schoolchildren, evidence about which built environmental characteristics influence walking or cycling to school remains inconclusive and is strongly context-dependent. This study aimed to identify the objective built environmental drivers of, and barriers to, active commuting to school for a multi-ethnic sample of 1,889 healthy primary schoolchildren (aged 5-11) in London, UK. Using cross-sectional multilevel ordered logistic regression modelling, supported by the spatial exploration of built environmental characteristics through cartography, the objective built environment was shown to be strongly implicated in children's commuting behaviour. In line with earlier research, proximity to school emerged as the prime variable associated with the choice for active commuting. However, other elements of the urban form were also significantly associated with children's use of active or passive modes of transport. High levels of accidents, crime and air pollution along the route to school were independently correlated with a lower likelihood of children walking or cycling to school. Higher average and minimum walkability and higher average densities of convenience stores along the way were independently linked to higher odds of active commuting. The significance of the relations for crime, air pollution and walkability disappeared in the fully-adjusted model including all built environmental variables. In contrast, relationships with proximity, traffic danger and the food environment were maintained in this comprehensive model. Black children, pupils with obesity, younger participants and those from high socioeconomic families were less likely to actively commute to school. There is thus a particular need to ensure that roads with high volumes of actively commuting children are kept safe and clean, and children's exposure to unhealthy food options along the way is limited. Moreover, as short commuting distances are strongly correlated with walking or cycling, providing high-quality education near residential areas might incite active transport to school.

show abstract

Section: Potential Confoundersmentioning

confidence: 99%

Associations of the objective built environment along the route to school with children’s modes of commuting: A multilevel modelling analysis (the SLIC study)

Bosch

Wells

Lum³

et al. 2020

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, marked differences in lung function and allergic sensitization between children of different racial backgrounds exist even when known confounders including socioeconomic status are taken into account. 18–20 For example, spirometric assessment of forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC) are known to be reduced by 14% in individuals of African ancestry compared with those of European ancestry. 21–24 The use of race-specific reference equations can help to minimize such differences and improve accuracy.…”

Section: Atopic Disorders and Racementioning

confidence: 99%

“…21–24 The use of race-specific reference equations can help to minimize such differences and improve accuracy. 20,25 …”

Section: Atopic Disorders and Racementioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

show abstract

“…In the UK, healthy controls were not enrolled, since the GLI-2012 had been previously validated for children of black African origin. 19 Individuals who had respiratory symptoms or felt unwell on the test day and those who performed a low-quality spirometry 20 21 were excluded. Patients who had experienced SCArelated acute events (eg, pain crises) in the last month were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Differences in lung function between children with sickle cell anaemia from West Africa and Europe

Arigliani

Castriotta

Zubair

et al. 2019

Thorax

Self Cite

View full text Add to dashboard Cite

IntroductionLung function abnormalities are common in sickle cell anaemia (SCA) but data from sub-Saharan Africa are limited. We hypothesised that children with SCA from West Africa had worse lung function than their counterparts from Europe.MethodsThis prospective cross-sectional study evaluated spirometry and anthropometry in black African individuals with SCA (haemoglobin phenotype SS) aged 6–18 years from Nigeria and the UK, when clinically stable. Age-matched controls were also included in Nigeria to validate the Global Lung Initiative spirometry reference values.ResultsNigerian SCA patients (n=154) had significant reductions in both FEV1 and FVC of ~1 z-score compared with local controls (n=364) and ~0.5 z-scores compared with the UK patients (n=101). Wasting (body mass index z-score<−2) had a prevalence of 27% in Nigerian patients and 7% in the UK ones (p<0.001). Among children with SCA, being resident in Nigeria (OR 2.4, 95% CI 1.1 to 4.9), wasting (OR 2.3, 95% CI 1.1 to 5.0) and each additional year of age (OR 1.2, 95% CI 1.1 to 1.4) were independently associated with increased risk of restrictive spirometry (FVC z-score<−1.64+FEV1/FVC≥−1.64).ConclusionsThis study showed that chronic respiratory impairment is more severe in children with SCA from West Africa than Europe. Our findings suggest the utility of implementing respiratory assessment in African children with SCA to early identify those with chronic lung injury, eligible for closer follow-up and more aggressive therapies.

show abstract

Lung function in children in relation to ethnicity, physique and socioeconomic factors

Cited by 42 publications

References 36 publications

Associations of the objective built environment along the route to school with children’s modes of commuting: A multilevel modelling analysis (the SLIC study)

Associations of the objective built environment along the route to school with children’s modes of commuting: A multilevel modelling analysis (the SLIC study)

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Differences in lung function between children with sickle cell anaemia from West Africa and Europe

Contact Info

Product

Resources

About