Lung function growth trajectories in non-asthmatic children aged 4–9 in relation to prenatal exposure to airborne particulate matter and polycyclic aromatic hydrocarbons – Krakow birth cohort study

Majewska, Renata; Pac, Agnieszka; Mróz, Elżbieta; Spengler, John D.; Camann, David; Mrozek-Budzyn, Dorota; Sowa, Agata; Jacek, Ryszard; Wheelock, Kylie; Perera, Frederica P.

doi:10.1016/j.envres.2018.05.037

Cited by 19 publications

(9 citation statements)

References 68 publications

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“…Along with our previous study [8], the associations between PAH exposure and altered lung function have been widely conducted in occupational [33], pediatric [34,35] and general populations [36]. It is generally believed that oxidative stress plays a pivotal role in the pathogenic process following PAH exposure.…”

Section: Discussionmentioning

confidence: 67%

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Cao

Zhou

Tan³

et al. 2020

Environ Health

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Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore the potential mediating role of oxidative DNA or lipid damage in the association between PAH exposure and lung function. Methods: The urinary levels of monohydroxy polycyclic aromatic hydrocarbon metabolites (OH-PAHs) and lung function parameters were measured among 3367 participants from the baseline of the Wuhan-Zhuhai cohort. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-isoprostane (8-iso-PGF2α) were determined to evaluate the individuals' oxidative DNA and lipid damage degrees, respectively. Linear mixed models were used to investigate the associations of urinary OH-PAHs, 8-OHdG and 8-iso-PGF2α with lung function parameters. Mediation analysis was further conducted to assess the potential role of oxidative damage in the association between urinary OH-PAHs and lung function. Results: Each one-percentage increase in the sum of urinary OH-PAHs, high-molecular-weight or low-molecular-weight OH-PAHs (ƩOH-PAHs, ƩHMW OH-PAH or ƩLMW OH-PAHs, respectively) was associated with a 0.2152-, 0.2076-or 0.1985ml decrease in FEV 1 , and a 0.1891-, 0.2195-or 0.1634-ml decrease in FVC, respectively. Additionally, significantly positive dose-response relationships of ƩOH-PAHs, ƩHMW OH-PAH and ƩLMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2α, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05). Mediation analysis indicated that urinary 8-OHdG mediated 14.22% of the association between ƩHMW OH-PAH and FVC. Conclusion: Higher levels of oxidative DNA damage might be involved in the decreased levels of FVC caused by highmolecular-weight PAH exposure.

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Section: Discussionmentioning

confidence: 67%

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Cao

Zhou

Tan³

et al. 2020

Environ Health

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“…24,25 Additionally, longitudinal studies in the United States, Europe, Mexico, and China have shown that air pollution and airborne particulate matter are associated with long-term abnormal lung function and lower lung function trajectories in children. [26][27][28][29] Each of these risk factors is important.…”

Section: Discussionmentioning

confidence: 99%

Reduction in mouse allergen exposure is associated with greater lung function growth

Grant

Phipatanakul

Perzanowski

et al. 2020

Journal of Allergy and Clinical Immunology

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Background: Current childhood asthma therapies have little effect on lung function trajectory. Objective: We sought to determine whether mouse allergen exposure reduction is associated with lung function growth in mouse-sensitized/exposed asthmatic children. Methods: Three hundred fifty mouse-sensitized/exposed asthmatic children (5-17 years old) were enrolled in a 1-year randomized trial of integrated pest management plus education versus education alone. Prebronchodilator/postbronchodilator spirometry was performed at baseline and 6 and 12 months, and bedroom floor mouse allergen levels were measured every 3 months. Mouse allergen reduction was defined as a 75% or greater decrease in mouse allergen levels from baseline. Treatment groups were combined for analyses because there were no differences in outcomes between groups. Changes in lung function over time were modeled, adjusting for age, sex, race, atopy, group, and bronchodilator reversibility and including an interaction term (allergen reduction*time). Results: The study population was predominantly black (79.4%) and low income (66.3% [<$30,000]). At baseline, the median mouse allergen level was 5.7 mg/g (interquartile range, 1.5-22.8 mg/g), and the mean (SD) prebronchodilator FEV 1 / forced vital capacity ratio was 80.2% (9.0%). Ninety-two (26.3%) participants had 75% or greater reduction in mouse allergen levels. For a 10-year-old black boy, 75% or greater allergen reduction was associated with an increase in prebronchodilator FEV 1 of 238 mL/y (95% CI, 177-299 mL/y), whereas less than 75% allergen reduction was associated with an increase in prebronchodilator FEV 1 of 131 mL/y (95% CI, 97-166 mL/y).

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“…Another prospective study showed that non-asthmatic children aged 4–9 years living in Kraków, who were prenatally exposed to higher levels of PM 2.5 as PAH, had significantly lower initial values of FVC and FEV1 compared to the control group [ 54 ] and that the rate of increase in both parameters remained similar. Therefore, it seems that the burden of the initial effect of prenatal exposure remains uncompensated over time [ 54 ].…”

Section: Childrenmentioning

confidence: 99%

Air Pollution in Poland: A 2022 Narrative Review with Focus on Respiratory Diseases

Nazar

Niedoszytko

2022

IJERPH

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According to the World Bank Group, 36 of the 50 most polluted cities in the European Union are in Poland. Thus, ambient air pollution and its detrimental health effects are a matter of immense importance in Poland. This narrative review aims to analyse current findings on air pollution and health in Poland, with a focus on respiratory diseases, including COVID-19, as well as the Poles’ awareness of air pollution. PubMed, Scopus and Google Scholar databases were searched. In total, results from 71 research papers were summarized qualitatively. In Poland, increased air pollution levels are linked to increased general and respiratory disease mortality rates, higher prevalence of respiratory diseases, including asthma, lung cancer and COVID-19 infections, reduced forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). The proximity of high traffic areas exacerbates respiratory health problems. People living in more polluted regions (south of Poland) and in the winter season have a higher level of air pollution awareness. There is an urgent need to reduce air pollution levels and increase public awareness of this threat. A larger number of multi-city studies are needed in Poland to consistently track the burden of diseases attributable to air pollution.

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Lung function growth trajectories in non-asthmatic children aged 4–9 in relation to prenatal exposure to airborne particulate matter and polycyclic aromatic hydrocarbons – Krakow birth cohort study

Cited by 19 publications

References 68 publications

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Reduction in mouse allergen exposure is associated with greater lung function growth

Air Pollution in Poland: A 2022 Narrative Review with Focus on Respiratory Diseases

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