2008
DOI: 10.1080/08958370701874671
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Lung Function Changes in Sprague-Dawley Rats After Prolonged Inhalation Exposure to Silver Nanoparticles

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Cited by 333 publications
(210 citation statements)
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“…In a subchronic repeated dose study, silver NPs with concentrations of 6.6 Â 10 5 to 2.9 Â 10 6 particles/cm 3 were investigated (Sung et al, 2008). At the highest dosage, changes in lung function and histopathological changes in the lung tissue were detected (Sung et al, 2008). A more detailed analysis of the data revealed bile duct hyperplasia at the highest dose (Sung et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In a subchronic repeated dose study, silver NPs with concentrations of 6.6 Â 10 5 to 2.9 Â 10 6 particles/cm 3 were investigated (Sung et al, 2008). At the highest dosage, changes in lung function and histopathological changes in the lung tissue were detected (Sung et al, 2008). A more detailed analysis of the data revealed bile duct hyperplasia at the highest dose (Sung et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…At the highest dose, increased blood calcium was found, but no adverse effect could be assigned to these observations. In a subchronic repeated dose study, silver NPs with concentrations of 6.6 Â 10 5 to 2.9 Â 10 6 particles/cm 3 were investigated (Sung et al, 2008). At the highest dosage, changes in lung function and histopathological changes in the lung tissue were detected (Sung et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Po 12-tygodniowej obserwacji od ustania narażenia ustalono wartość 117 mg/m 3 jako najwyższe stężenie, przy któ-rym nie obserwowano działania toksycznego (no observable adverse effect concentration -NOAEC), biorąc pod uwagę zmiany funkcjonowania płuc (podobne jak we wcześniejszych badaniach (22,6) A.M. Świdwińska-Gajewska, S. Czerczak Nr 6 836 U myszy narażanych inhalacyjnie na nanocząstki srebra (5 nm) przez 10 dni wykazano jedynie łagodny stan zapalny w płucach (7). Odnotowano statystycznie istotny wzrost całkowitej liczby komórek w popłuczy-nach oskrzelowo-pęcherzykowych (bronchoalveolar lavage fluid -BALF) oraz neutrofili, natomiast nie zaobserwowano różnic w aktywności dehydrogenazy mleczanowej (lactate dehydrogenase -LDH) i poziomu białka całkowitego między grupami (7).…”
Section: Narażenie Drogą Inhalacyjnąunclassified
“…A recent research on lower group of animal demonstrated that bigger size AgNps causes severe accumulation and damage of GI system and hampers absorption with flow of nutrition to requisite sight [17]. Bigger size AgNps gained entrance into the human body mostly through oral entry portal route and in powdered form it spreads easily in air, soil and water.…”
Section: Journal Of Nutritional Disorders and Therapymentioning
confidence: 99%