Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals

Ma, Ya‐Hui; Shen, Ling-Xiao; Li, Yuzhu; Leng, Yue; Liu, Yang; Chen, Shi-Dong; He, Xiao‐Yu; Zhang, Yaru; Chen, Renjie; Feng, Jianfeng; Tan, Lei; Dong, Qiang; Suckling, John; Smith, Anélda; Cheng, Wei; Yu, Jin-Tai

doi:10.1016/j.bbi.2023.02.009

Cited by 16 publications

(22 citation statements)

References 39 publications

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“…Our findings regarding lung and cognitive function at baseline are consistent with prior research [ 29 , 30 ]. Previous studies have linked decreased lung function to poor cognitive function and dementia [ 31 , 32 ]. Moreover, decreased pulmonary function is more likely to predict cognition decline [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Hu,

Tang,

Zhan

2024

BMC Public Health

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Background The relationship between lung function and sarcopenia remains ambiguous. The primary aim of this study was to investigate the potential association between lung function and sarcopenia in the older adults, as well as to examine the mediating role of cognitive function in this relationship. Methods The participants were selected from a nationally representative population-based cohort in China. The peak expiratory flow (PEF) measurement was used to evaluate the lung function in older persons. The sarcopenia was diagnosed using the guidelines of the Asian Working Group for Sarcopenia (AWGS) in 2019. The Cox proportional hazard model was utilized to perform primary analyses of the relationship between PEF and sarcopenia. The mediating effect of cognitive function was evaluated using the counterfactual mediation method. Results This cohort study included 4,011 older adults (average age, 66.6 years; 53.3% males). During a follow-up period of 3.86 years, 349 individuals were diagnosed with sarcopenia. After adjusting for potential confounders, each one-standard-deviation increase in PEF was associated with a 28% reduction in the risk of sarcopenia (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.63, 0.80). There was a significant mediation of cognition for the association between PEF and incident sarcopenia, and the proportion mediated was 12.2% (95% CI: 4.5%, 23.1%). Conclusions Older adults with impaired lung function are more likely to develop sarcopenia. Nevertheless, cognition can explain only a small portion of this association. Thus, other potential pathways between lung function and sarcopenia must be elucidated.

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Section: Discussionmentioning

confidence: 99%

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Hu,

Tang,

Zhan

2024

BMC Public Health

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“…Based on the evidence of potential pathways [13][14][15][16][17][18], 25 blood biomarkers including inflammation, erythrocytes, liver and renal function, and 168 plasma metabolites were selected as potential mediators. In the UKB, blood tests were performed on participants with informed consent at baseline recruitment.…”

Section: Assessment Of Potential Mediatorsmentioning

confidence: 99%

“…Existing epidemiological studies have established links between abnormal lung function and various biomarkers, including liver [ 13 ], kidney [ 14 ], erythrocytes [ 15 ], inflammation [ 16 ], and circulating metabolites [ 17 ]. These biomarkers are also closely associated with the development of depression [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…These biomarkers are also closely associated with the development of depression [ 18 ]. For example, impaired lung function may cause cerebral hypoxia and metabolic disturbances [ 16 ], which in turn trigger a pro-inflammatory state with the release of large amounts of pro-inflammatory factors that elevate the level of the systemic inflammatory response, resulting in the occurrence of depressive symptoms [ 8 ]. Nonetheless, to date, no population-based cohort studies have investigated whether and to what extent these biomarkers may mediate the association between abnormal lung function and depression risks.…”

Section: Introductionmentioning

confidence: 99%

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Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Hu,

Liu,

Jia

2024

BMC Med

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Background Lung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the prospective association between impaired lung function and incident depression and the underlying biological mechanisms. Methods This prospective cohort study comprised 280,032 non-depressed individuals with valid lung function measurements from the UK Biobank. Lung function was assessed through the forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV1). Cox proportional hazard models were applied to estimate the associations between lung function and incident depression. Mediation analyses were fitted to investigate the potential mediating role of biomarkers and metabolites in the association. Results A total of 9514 participants (3.4%) developed depression during a median follow-up of 13.91 years. Individuals in the highest quartile had a lower risk of depression (FVC % predicted: HR = 0.880, 95% CI = 0.830–0.933; FEV1% predicted: HR = 0.854, 95% CI = 0.805–0.905) compared with those in the lowest quartile of the lung function indices. Additionally, the restricted cubic splines suggested lung function indices had reversed J-shaped associations with incident depression (nonlinear P < 0.05 for FVC % predicted and FEV1% predicted). Impaired lung function yielded similar risk estimates (HR = 1.124, 95% CI = 1.074–1.176). Biomarkers involving systemic inflammation, erythrocytes, and liver and renal function may be potential mediators in the lung function-depression association. Conclusions This study revealed that the higher risk of developing depression was associated with impaired lung function. Also, the association might be partially mediated by biomarkers including systemic inflammation, erythrocytes, and liver and renal function, though these mediation findings should be interpreted with caution due to potential temporal ambiguity.

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“…An example is the lower degree of pain observed in AD patients [32]. About peripheral biomarkers, in human fluids, in addition to looking at the levels of Aβ or tau protein in cerebral spinal fluid (CSF) [33,34], other peripheral fluids, like plasma, saliva, or urine, have been used as possible markers of compounds, like proinflammatory cytokines, or others, that could be altered in AD patients [35]. The kinetics for the appearance of these markers could be important since earlier markers could facilitate the earlier prevention of the disease [35].…”

Section: Is There Any Relation Between Peripheral Nervous System and Ad?mentioning

confidence: 99%

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Ávila

Pérez

Ávila-Villanueva

et al. 2023

Explor Neuroprot Ther

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Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggregates) or neurofibrillary tangles (constructed of tau protein polymers). However, the existence of adequate disease modifiers based on such targets is discussed. In this special issue, it has been suggested to search for new possible targets for AD therapy. This contribution tries to analyze non-neuronal tissues (periphery) to identify potential factors (target) involved in the development of AD.

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Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals

Cited by 16 publications

References 39 publications

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Cognition as mediator of pulmonary function and risk of sarcopenia among older adults

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

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