Abstract:IntroductionMost cases of the 2009 influenza A (H1N1) infection are self-limited, but occasionally the disease evolves to a severe condition needing hospitalization. Here we describe the evolution of the respiratory compromise, ventilatory management and laboratory variables of patients with diffuse viral pneumonitis caused by pandemic 2009 influenza A (H1N1) admitted to the ICU.MethodThis was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring me… Show more
“…Another relevant data refers to the body mass index (BMI), which can be a risk factor for the development of various diseases, and also a signi icant factor to the worsening of the patient with the In luenza A virus (H1NI) (8). In the present research the data points to a high percentage, 81.81%, of patients with a BMI of ≥25kg/m².…”
Section: Discussionsupporting
confidence: 47%
“…In the more serious cases, survivors presented great bilateral pulmonary damage in 2 or more quadrants and signs of aveolar in iltrates with a substantial systemic in lammatory response, evidenced by radiography. These alterations had a great impact on oxygenation and induced severe pulmonary lesion (2,6,7,8).…”
Introduction:The in luenza A (H1N1) was responsible for the 2009 pandemic, especially with severe pulmonary complications. Objective: To describe characteristics of patients in a university hospital in Curitiba -PR with laboratory diagnosis of in luenza A (H1N1) and its post hospital discharge in the 2009 lung function pandemic Methodology: A retrospective observational study. It was used as a data source the institution Epidemiology Service (SEPIH) and spirometry tests of patients who were admitted in 2009, 18 years without lung disease associated and non-pregnant. Descriptive statistics were used and applied Fisher's exact test for relationship between comorbidity and spirometry tests. Results: There were 84 con irmed cases, of these 11 were eligible for the study with a mean age of 44.27 years (± 9.63) and 63.63% males. 54.54% of the 11 patients had comorbidities associated with systemic arterial hypertension (54.54%), diabetes (18.18%) and late postoperative period of kidney transplantation (18.18%) were the most frequent. Most patients (81.81%) had BMI ≥ 25kg / m². The Spirometry test was performed approximately 40.09 (± 15.27) days after discharge, of these, 5 had restrictive pattern and all had abnormal chest radiograph results. There was no statistically signi icant difference between the results of Spirometry and comorbidities (p=0.24). Conclusions: The group evaluated in this research did not show a direct relationship between Spirometry and comorbidities, but changes in Spirometry in some patients after hospital discharge stood out, suggesting changes in lung function due to in luenza A (H1N1).
Keywords
“…Another relevant data refers to the body mass index (BMI), which can be a risk factor for the development of various diseases, and also a signi icant factor to the worsening of the patient with the In luenza A virus (H1NI) (8). In the present research the data points to a high percentage, 81.81%, of patients with a BMI of ≥25kg/m².…”
Section: Discussionsupporting
confidence: 47%
“…In the more serious cases, survivors presented great bilateral pulmonary damage in 2 or more quadrants and signs of aveolar in iltrates with a substantial systemic in lammatory response, evidenced by radiography. These alterations had a great impact on oxygenation and induced severe pulmonary lesion (2,6,7,8).…”
Introduction:The in luenza A (H1N1) was responsible for the 2009 pandemic, especially with severe pulmonary complications. Objective: To describe characteristics of patients in a university hospital in Curitiba -PR with laboratory diagnosis of in luenza A (H1N1) and its post hospital discharge in the 2009 lung function pandemic Methodology: A retrospective observational study. It was used as a data source the institution Epidemiology Service (SEPIH) and spirometry tests of patients who were admitted in 2009, 18 years without lung disease associated and non-pregnant. Descriptive statistics were used and applied Fisher's exact test for relationship between comorbidity and spirometry tests. Results: There were 84 con irmed cases, of these 11 were eligible for the study with a mean age of 44.27 years (± 9.63) and 63.63% males. 54.54% of the 11 patients had comorbidities associated with systemic arterial hypertension (54.54%), diabetes (18.18%) and late postoperative period of kidney transplantation (18.18%) were the most frequent. Most patients (81.81%) had BMI ≥ 25kg / m². The Spirometry test was performed approximately 40.09 (± 15.27) days after discharge, of these, 5 had restrictive pattern and all had abnormal chest radiograph results. There was no statistically signi icant difference between the results of Spirometry and comorbidities (p=0.24). Conclusions: The group evaluated in this research did not show a direct relationship between Spirometry and comorbidities, but changes in Spirometry in some patients after hospital discharge stood out, suggesting changes in lung function due to in luenza A (H1N1).
Keywords
“…A summary of published studies on NIV in pH1N1 is shown in table 2 [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][36][37][38][39][40][41][42][43][44][45][46][47][48]. Of the 22 studies included in table 2, the majority were case series reports.…”
Section: Introductionmentioning
confidence: 99%
“…These included obesity, COPD, diabetes mellitus, asthma, immunosuppression, chronic kidney disease and heart failure [27][28][29][30]32]. The overall ICU mortality rate for critically ill cases of pH1N1 was close to 17% [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”
Section: Introductionmentioning
confidence: 99%
“…The use of NIV as initial ventilator support for respiratory failure in the presence of SARS appears to be a reasonable option, albeit under strict infection control measures. [18][19][20][21][22][23][24][25][26][27][28][29][30]. The pH1N1 virus originated from the swine influenza (H1N1) virus circulating in North American pigs [23].…”
The aim of this article was to review the role of noninvasive ventilation (NIV) in acute pulmonary infectious diseases, such as severe acute respiratory syndrome (SARS), H1N1 and tuberculosis, and to assess the risk of disease transmission with the use of NIV from patients to healthcare workers.We performed a clinical review by searching Medline and EMBASE. These databases were searched for articles on ''clinical trials'' and ''randomised controlled trials''. The keywords selected were non-invasive ventilation pulmonary infections, influenza-A (H1N1), SARS and tuberculosis. These terms were crossreferenced with the following keywords: health care workers, airborne infections, complications, intensive care unit and pandemic. The members of the International NIV Network examined the major results regarding NIV applications and SARS, H1N1 and tuberculosis. Cross-referencing mechanical ventilation with SARS yielded 76 studies, of which 10 studies involved the use of NIV and five were ultimately selected for inclusion in this review. Cross-referencing with H1N1 yielded 275 studies, of which 27 involved NIV. Of these, 22 were selected for review. Cross-referencing with tuberculosis yielded 285 studies, of which 15 involved NIV and from these seven were selected. In total 34 studies were selected for this review.NIV, when applied early in selected patients with SARS, H1N1 and acute pulmonary tuberculosis infections, can reverse respiratory failure. There are only a few reports of infectious disease transmission among healthcare workers. @ERSpublications NIV in high risk pulmonary infection management can prevent respiratory failure in ICUs with well trained staff
Background Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefits or harms. This is an update of a review first published in 2016. Objectives To systematically assess the e ectiveness and potential adverse e ects of corticosteroids as adjunctive therapy in the treatment of influenza, taking into account di erences in timing and doses of corticosteroids.
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