Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study

Mannino, David M.; Buist, A. Sonia; Petty, Thomas L.; Enright, Paul; Redd, Stephen C.

doi:10.1136/thorax.58.5.388

Cited by 670 publications

(659 citation statements)

References 24 publications

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“…Impaired lung function is a generic term that includes two different spirometric patterns, obstructive lung dysfunction and restrictive lung dysfunction (Mannino et al, 2003a(Mannino et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic syndrome and lung function in schizophrenia: A pilot study

Vancampfort

Probst

Stubbs

et al. 2014

Psychiatry Research

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Section: Introductionmentioning

confidence: 99%

“…Conversely, restrictive lung dysfunction is characterized by a proportionally comparable decrease of both FEV1% and FVC expressed as percent of the predicted value (FVC%), consequently resulting in a normal FEV1/FVC ratio (Mannino et al, 2003a(Mannino et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and lung function in schizophrenia: A pilot study

Vancampfort

Probst

Stubbs

et al. 2014

Psychiatry Research

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“…The OLIN longitudinal COPD study that was the basis for recruitment of the present study population includes a large population-based COPD cohort comparable to that of NHANES I [42]. Long-term follow-ups of population-based COPD cohorts, in which COPD is classified according to spirometric criteria of accepted guidelines, are rare.…”

Section: Discussionmentioning

confidence: 99%

From COPD epidemiology to studies of pathophysiological disease mechanisms: challenges with regard to study design and recruitment process

Lindberg

Linder

Bäckman

et al. 2017

European Clinical Respiratory Journal

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Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study. Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV1 and group B) COPD grade 2–3 without rapid decline in FEV1 (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D. Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome. Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.

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“…Therefore, the findings of this study are consistent with previous data. In addition, severely impaired lung function is a significant predictor of lung cancer and this fact is still under appreciated among some medical professionals (29).…”

Section: Discussionmentioning

confidence: 99%

“…Impaired lung function is a significant predictor of mortality (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd.…”

Section: Introductionmentioning

confidence: 99%

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

Sekine

Gaina

et al. 2007

Environ Health Prev Med

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Objectives: Only a few long-term follow-up studies with a focus on the association between lung function and mortality in the Japanese population have been undertaken. In this study, we examined the associations of lung function, smoking and the results of allergy skin tests with mortality in a longitudinal study of the Japanese population.Methods: Baseline measurements were performed on residents of Fukui, Japan in 1972, and a follow-up survey was conducted in 2002. By employing a nested case-control design, 596 cases (deaths) and 596 age and sex-matched controls (survivals) were selected. Lung function was assessed using forced vital capacity (FVC) expressed as the normal percent predicted (FVC %pred) and the ratio of forced expiratory volume in 1 second (FEV 1 ) to FVC (FEV 1 /FVC). Allergy skin tests were performed with extracts of house dust, candidia and mixed fungal samples (bronchomycosis). The Brinkman index was used to assess smoking intensity. The Cox proportional hazards model was used to evaluate whether lung function was associated with mortality after adjustment for other potential confounding variables.Results: Those categorized into the first-or second-lowest quartile of FVC %pred had a higher mortality [hazard ratios (HRs) and 95% confidence intervals (CIs): 2.01 (1.26−3.19) and 1.84 (1.11− 3.05)], respectively. On top of these, heavy smoking (BI≥400) was associated with a higher mortality [HR and 95%CI: 1.73 (1.18−2.53)]. There were only weak of associations between the results of allergy skin tests and mortality.Conclusions: These results suggest that FVC %pred of lung function and smoking can serve as long-term independent predictors of mortality.

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Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study

Cited by 670 publications

References 24 publications

Metabolic syndrome and lung function in schizophrenia: A pilot study

Metabolic syndrome and lung function in schizophrenia: A pilot study

From COPD epidemiology to studies of pathophysiological disease mechanisms: challenges with regard to study design and recruitment process

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

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