2009
DOI: 10.1080/13547500902989088
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Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter

Abstract: Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO(2)) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO(2) and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO(2) interacted synergistically to decrease serum CC16 but not to increase serum SP-D. While further illustrating the potential of serum CC16 an… Show more

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Cited by 11 publications
(9 citation statements)
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“…These clinical observations are supported by in vitro observations that nicotine can cause reduced levels of SP-D in human airway epithelial cells ( 366 ). Additional studies have demonstrated increased circulating SP-D with tobacco smoking or other types of noxious exposure, including data from a twin study showing that smoking monozygotic twins had markedly increased serum SP-D relative to their non-smoking twins, despite the very high heritability of serum SP-D levels ( 208 , 252 , 280 , 340 , 367 , 368 ); however, smoke-induced serum levels may not be clearly evident in mixed populations of respiratory patients, where SP-D levels may be influenced by other processes ( 369 ). As described earlier, cigarette smoke disrupts the quaternary structure of SP-D molecules ( 252 ).…”
Section: The Role Of Sp-d In Respiratory Diseasementioning
confidence: 99%
“…These clinical observations are supported by in vitro observations that nicotine can cause reduced levels of SP-D in human airway epithelial cells ( 366 ). Additional studies have demonstrated increased circulating SP-D with tobacco smoking or other types of noxious exposure, including data from a twin study showing that smoking monozygotic twins had markedly increased serum SP-D relative to their non-smoking twins, despite the very high heritability of serum SP-D levels ( 208 , 252 , 280 , 340 , 367 , 368 ); however, smoke-induced serum levels may not be clearly evident in mixed populations of respiratory patients, where SP-D levels may be influenced by other processes ( 369 ). As described earlier, cigarette smoke disrupts the quaternary structure of SP-D molecules ( 252 ).…”
Section: The Role Of Sp-d In Respiratory Diseasementioning
confidence: 99%
“…Given that some of the variation seen in the published literature might be explained by the use of different antibodies, we detected SP-D in serum and plasma samples using either the ELISA kit's detection antibody or the polyclonal goat anti-SP-D antibody. While there is no significant difference between detection by the [12,13,[17][18][19]21,25,28,38,[43][44][45]49,50,59,61,77,84,89], BioVendor [14,[31][32][33][34][35][36]46,52,56,64,65,72,75,76,79,80], and Holmskov et al [3,39,[53][54][55]58,62,66,69,70,78,85,86]) were compared. b) The range of healthy control ...…”
Section: Influence Of Detection Antibody On Extrapolated Sp-d Levelmentioning
confidence: 99%
“…Accordingly, we compared circulating monocyte MMP-9 production with the wholelung emphysema severity as determined by quantitative CT scan analysis and with two systemic markers of active lung injury (Clara cell secretory protein [CCSP] and surfactant protein-D [SP-D]) (16)(17)(18) that are altered in current smokers and subjects with COPD (19)(20)(21)(22)(23)(24). Some of the results of this manuscript have been previously published in the form of an abstract (25).…”
Section: What This Study Adds To the Fieldmentioning
confidence: 99%