Lung elastic recoil during breathing at increased  lung volume

Rodarte, Joseph R.; Noredin, Gassan; Miller, Charles C.; Brusasco, Vito; Pellegrino, Riccardo

doi:10.1152/jappl.1999.87.4.1491

Cited by 25 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Main results: Tiotropium induced a significant increase in FEV 1 and FVC but not in IC. At baseline, FRC pleth , RV pleth and TLC pleth were higher than FRC He , RV He and TLC He .…”

Section: Discussionmentioning

confidence: 87%

“…Chronic obstructive pulmonary disease (COPD) is a disease characterized by progressive airflow limitation along with changes in lung compliance and elastic recoil that are manifested by hyperinflation [1]. Lung hyperinflation, defined as an abnormal increase in the volume of air remaining in the lungs at the end of spontaneous expiration, is present in COPD because of the effects of increased lung compliance as a result of the permanently destructive changes of emphysema and expiratory flow limitation [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD

Cazzola

Rogliani

Curradi

et al. 2009

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Main results: Tiotropium induced a significant increase in FEV 1 and FVC but not in IC. At baseline, FRC pleth , RV pleth and TLC pleth were higher than FRC He , RV He and TLC He .…”

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD

Cazzola

Rogliani

Curradi

et al. 2009

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Lung elastic recoil also varies with lung volume. Rodarte et al (1999) obtained a rapid decrease in lung recoil with voluntary increases in lung volume. These Wndings indicate that lung stretch may cause stress relaxation of airway wall tissues.…”

Section: Discussionmentioning

confidence: 89%

Characteristics of the respiratory mechanical and muscle function of competitive breath-hold divers

et al. 2008

View full text Add to dashboard Cite

Competitive breath-hold divers (BHD) employ glossopharyngeal insufflation (GI) to increase intrapulmonary oxygen stores and prevent the lungs from dangerous compressions at great depths. Glossopharyngeal insufflation is associated with inflation of the lungs beyond total lung capacity (TLC). It is currently unknown whether GI transiently over-distends the lungs or adversely affects lung elastic properties in the long-term. Resting lung function, ventilatory drive, muscle strength, and lung compliance were measured in eight BHD who performed GI since 5.5 (range 2-6) years on average, eight scuba divers, and eight control subjects. In five BHD subsequent measures of static lung compliance (Cstat) were obtained after 1 and 3 min following GI. Breath-hold divers had higher than predicted ventilatory flows and volumes and did not differ from control groups with regard to gas transfer, inspiratory muscle strength, and lung compliance. A blunted response to CO2 was obtained in BHD as compared to control groups. Upon GI there was an increase in mean vital capacity (VCGI) by 1.75 +/- 0.85 (SD) L compared to baseline (p < 0.001). In five BHD Cstat raised from 3.7 (range 2.9-6.8) L/kPa at baseline to 8.1 (range 3.4-21.2) L/kPa after maximal GI and thereafter gradually decreased to 5.6 (range 3.3-8.1) L/kPa after 1 min and 4.2 (range 2.7-6.6) L/kPa after 3 min (p < 0.01). We conclude that in experienced BHD there is a transient alteration in lung elastic recoil. Resting lung function did not reveal a pattern indicative of altered lung ventilatory or muscle function.

show abstract

“…Alternatively, the greater response to MCh after the series of deep breaths might have been due to mechanical unloading of the airways. Because of imperfect rheological properties, the elastic recoil of lung parenchyma decreases after a deep inspiration and needs time to recover (20). Therefore, the external load on airway smooth muscle will be transiently reduced after a deep breath.…”

Section: Discussionmentioning

confidence: 99%

Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects

Crimi

Pellegrino

Milanese

et al. 2002

Journal of Applied Physiology

Self Cite

View full text Add to dashboard Cite

Crimi, Emanuele, Riccardo Pellegrino, Manlio Milanese, and Vito Brusasco. Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects. J Appl Physiol 93: 1384-1390, 2002. First published June 21, 2002 10.1152/japplphysiol.00209.2002Deep breaths taken before inhalation of methacholine attenuate the decrease in forced expiratory volume in 1 s and forced vital capacity in healthy but not in asthmatic subjects. We investigated whether this difference also exists by using measurements not preceded by full inflation, i.e., airway conductance, functional residual capacity, as well as flow and residual volume from partial forced expiration. We found that five deep breaths preceding a single dose of methacholine 1) transiently attenuated the decrements in forced expiratory volume in 1 s and forced vital capacity in healthy (n ϭ 8) but not in mild asthmatic (n ϭ 10) subjects and 2) increased the areas under the curve of changes in parameters not preceded by a full inflation over 40 min, during which further deep breaths were prohibited, without significant difference between healthy (n ϭ 6) and mild asthmatic (n ϭ 16) subjects. In conclusion, a series of deep breaths preceding methacholine inhalation significantly enhances bronchoconstrictor response similarly in mild asthmatic and healthy subjects but facilitates bronchodilatation on further full inflation in the latter.forced expiratory volume in 1 s; specific airway conductance; partial flow-volume curve; functional residual capacity; residual volume RECENT STUDIES HAVE SHOWN that deep breaths taken immediately before inhalation of methacholine (MCh) greatly modulate the bronchoconstrictor response in normal (10, 12, 21) but not in asthmatic (10) subjects. This would suggest that the shortening capacity of airway smooth muscle is reduced by previous lung stretching in healthy subjects, and the lack of such a bronchoprotective mechanism may be responsible for airway hyperresponsiveness in asthma. A mechanistic interpretation of the above studies is, however, limited by the use of forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC), measurements that are highly and variably affected by the full lung inflation preceding the forced expiratory maneuver. During induced bronchoconstriction, a full inflation transiently increases airway caliber, and the magnitude of this increase depends on the relative magnitude of the distending force of lung parenchyma and the constrictor force of airway smooth muscle (17). Therefore, any parameter derived from a full forced expiratory maneuver, including FEV 1 and FVC, will depend on both airway smooth muscle shortening capacity and airway wall response to a deep breath.It is reasonable to postulate that, if the lack of a bronchoprotective effect by multiple deep breaths taken before inhaling a constrictor agent in asthma is due to the inability to reduce the shortening capacity of airway smooth muscle, then the different effects of the deep breaths on airway response to MCh between asthmati...

show abstract

Lung elastic recoil during breathing at increased lung volume

Cited by 25 publications

References 15 publications

A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD

A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD

Characteristics of the respiratory mechanical and muscle function of competitive breath-hold divers

Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects

Contact Info

Product

Resources

About