Lung Disease and Asthma Severity in Adults with Asthma: Data from the Third National Health and Nutrition Examination

Savage-Brown, Amanda; Mannino, David M.; Redd, Stephen C.

doi:10.1081/jas-200067605

“…36 Patients in the Third National Health and Nutrition Examination Survey of 1063 adults 20 years of age or older with lifelong history of asthma had deterioration of lung function; not only did airway obstruction increase, but also a restrictive abnormality developed. 37 There are many reasons for this deterioration of lung function. Airway remodeling from persistent severe inflammation certainly is one.…”

Section: Asthma In Adultsmentioning

confidence: 99%

The natural history of asthma

Reed¹

2006

Journal of Allergy and Clinical Immunology

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“…Lung function has been found to decline in some but not all adult-onset asthma patients (154–156). In those with persistent asthma there is generally a decline in lung function that eventually leads to a restrictive pattern of spirometry (157). Adult lung function is influenced by initial FEV1 and sex, with a larger decline observed amongst females, but not initial asthma severity or allergic sensitization (136).…”

Section: Adult-onset Asthmamentioning

confidence: 99%

Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?

Trivedi

¹

,

Denton

²

2019

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Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.

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“…Lung function has been found to decline in some but not all adult-onset asthma patients (154)(155)(156). In those with persistent asthma there is generally a decline in lung function that eventually leads to a restrictive pattern of spirometry (157). Adult lung function is influenced by initial FEV1 and sex, with a larger decline observed amongst females, but not initial asthma severity or allergic sensitization (136).…”

Section: Lung Functionmentioning

confidence: 99%

Asthma in Children and Adults – What are The Differences and What Can They Tell us About Asthma?

2020

Frontiers Research Topics

0

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Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.

show abstract

Lung Disease and Asthma Severity in Adults with Asthma: Data from the Third National Health and Nutrition Examination

Cited by 13 publications

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The natural history of asthma

The natural history of asthma

Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?

Asthma in Children and Adults – What are The Differences and What Can They Tell us About Asthma?

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