Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

Mikhak, Zamaneh; Strassner, James P.; Luster, Andrew D.

doi:10.1084/jem.20130091

Cited by 151 publications

(149 citation statements)

References 62 publications

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“…Our findings extend recent reports that chemokine receptor expression on T cells regulates their homing to virally infected lungs (72). We thus show that both alloantigen-and Gα 1 -dependent chemokine signaling play a role in memory T lymphocyte migration into lungs.…”

Section: Discussionsupporting

confidence: 90%

Central memory CD8+ T lymphocytes mediate lung allograft acceptance

Krupnick¹,

Lin²,

Li³

et al. 2014

J. Clin. Invest.

113

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Memory T lymphocytes are commonly viewed as a major barrier for long-term survival of organ allografts and are thought to accelerate rejection responses due to their rapid infiltration into allografts, low threshold for activation, and ability to produce inflammatory mediators. Because memory T cells are usually associated with rejection, preclinical protocols have been developed to target this population in transplant recipients. Here, using a murine model, we found that costimulatory blockade-mediated lung allograft acceptance depended on the rapid infiltration of the graft by central memory CD8 + T cells (CD44 hi CD62L hi CCR7 + ). Chemokine receptor signaling and alloantigen recognition were required for trafficking of these memory T cells to lung allografts.

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Section: Discussionsupporting

confidence: 90%

Central memory CD8+ T lymphocytes mediate lung allograft acceptance

Krupnick¹,

Lin²,

Li³

et al. 2014

J. Clin. Invest.

113

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show abstract

“…Sun and colleagues showed that the ability of dendritic cells in the cervicovaginal tract to produce retinoic acid may explain in part the specific integrin program induced after cervicovaginal immunization (1). It extends previous results about the key role of local dendritic cells to imprint a specific program on T cells to favour their homing to the site of their initial activation (8,13).…”

Section: Induction Of Persistent Intraepithelial Cd8supporting

confidence: 87%

Resident Memory T Cells as Surrogate Markers of the Efficacy of Cancer Vaccines

Nizard

Roussel

Tartour

2016

Clinical Cancer Research

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Cancer vaccine boost via the cervicovaginal rather than the intramuscular route of immunization appears to be crucial to induce genital CD8+ T cells and tumor regression. This clinical activity is correlated with the ability of the mucosal boost to elicit resident memory T cells in the genital tract. Clin Cancer Res; 22(3); 530–2. ©2015 AACR. See related article by Sun et al., p. 657

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“…Experimental studies show that T cells are programmed during the activation process in the lymph node to express homing molecules that favor trafficking back to the site of the activation (2,3). Thus, we assume h ij ¼ h a if the T cell was activated in the given organ (organ i ¼ organ j ), and h ij ¼ h n otherwise (1 !…”

Section: Quick Guide To Equations and Assumptionsmentioning

confidence: 99%

Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions

et al. 2016

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It remains unclear how localized radiotherapy for cancer metastases can occasionally elicit a systemic antitumor effect, known as the abscopal effect, but historically, it has been speculated to reflect the generation of a host immunotherapeutic response. The ability to purposefully and reliably induce abscopal effects in metastatic tumors could meet many unmet clinical needs. Here, we describe a mathematical model that incorporates physiologic information about T-cell trafficking to estimate the distribution of focal therapy-activated T cells between metastatic lesions. We integrated a dynamic model of tumor-immune interactions with systemic T-cell trafficking patterns to simulate the development of metastases. In virtual case studies, we found that the dissemination of activated T cells among multiple metastatic sites is complex and not intuitively predictable. Furthermore, we show that not all metastatic sites participate in systemic immune surveillance equally, and therefore the success in triggering the abscopal effect depends, at least in part, on which metastatic site is selected for localized therapy. Moreover, simulations revealed that seeding new metastatic sites may accelerate the growth of the primary tumor, because T-cell responses are partially diverted to the developing metastases, but the removal of the primary tumor can also favor the rapid growth of preexisting metastatic lesions. Collectively, our work provides the framework to prospectively identify anatomically defined focal therapy targets that are most likely to trigger an immune-mediated abscopal response and therefore may inform personalized treatment strategies in patients with metastatic disease. Cancer Res; 76(5); 1009-18. Ó2016 AACR.

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Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

Abstract: Lung dendritic cells promote lung homing by T cells in part via up-regulation of chemokine receptor CCR4.

Cited by 151 publications

References 62 publications

Central memory CD8+ T lymphocytes mediate lung allograft acceptance

Central memory CD8+ T lymphocytes mediate lung allograft acceptance

Resident Memory T Cells as Surrogate Markers of the Efficacy of Cancer Vaccines

Abscopal Benefits of Localized Radiotherapy Depend on Activated T-cell Trafficking and Distribution between Metastatic Lesions

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