Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation

Schwab, Aaron D.; Wyatt, Todd A.; Nelson, Amy J.; Gleason, Angela; Gaurav, Rohit; Romberger, Debra J.; Poole, Jill A.

doi:10.1080/1547691x.2024.2332172

Cited by 1 publication

(1 citation statement)

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“…IL-10 is a representative immunoregulatory cytokine known to suppress the development of COPD by regulating the inflammatory response in lung tissue [ 97 – 99 ]. Similarly, it has been reported that COPD patients have lower IL-10 concentrations in their blood [ 100 , 101 ].…”

Section: Discussionmentioning

confidence: 99%

Botanical formulation HX110B ameliorates PPE-induced emphysema in mice via regulation of PPAR/RXR signaling pathway

Lee,

Lee

et al. 2024

PLoS ONE

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Chronic obstructive pulmonary disease (COPD), an inflammatory lung disease, causes approximately 3 million deaths each year; however, its pathological mechanisms are not fully understood. In this study, we examined whether HX110B, a mixture of Taraxacum officinale, Dioscorea batatas, and Schizonepeta tenuifolia extracts, could suppress porcine pancreatic elastase (PPE)-induced emphysema in mice and its mechanism of action. The therapeutic efficacy of HX110B was tested using a PPE-induced emphysema mouse model and human bronchial epithelial cell line BEAS-2B. In vivo data showed that the alveolar wall and air space expansion damaged by PPE were improved by HX110B administration. HX110B also effectively suppresses the expression levels of pro-inflammatory mediators including IL-6, IL-1β, MIP-2, and iNOS, while stimulating the expression of lung protective factors such as IL-10, CC16, SP-D, and sRAGE. Moreover, HX110B improved the impaired OXPHOS subunit gene expression. In vitro analysis revealed that HX110B exerted its effects by activating the PPAR-RXR signaling pathways. Overall, our data demonstrated that HX110B could be a promising therapeutic option for COPD treatment.

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Section: Discussionmentioning

confidence: 99%