Lung Damage in Rheumatoid Arthritis—A Retrospective Study

Dinache, Georgiana; Popescu, C; Mogoşan, Corina; Enache, Luminița; Agache, Mihaela; Codreanu, Cătălin

doi:10.3390/ijms24010028

Cited by 4 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, combined traditional DMARDs and anti-TNF-alpha treatments are considered controversial hypothetic ILD risk factors [ 10 , 17 ], while abatacept and rituximab are considered preferable in the case of ILD [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Its early identification represents an opportunity to avoid ILD progression, improve long-term outcomes and treat patients promptly with antifibrotic treatments, when indicated [ 13 , 14 ]. Furthermore, with most patients being oligo-symptomatic despite significant radiological abnormalities [ 15 ], optimal tools for early diagnosis and periodic screening are deemed essential during the follow-up, in the presence of predisposal conditions [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do Ultrasound Lung Abnormalities Correlate to Biomarkers and Male Gender in Rheumatoid Arthritis Patients? A Monocentric Cross-Sectional Study

Bandinelli,

Benucci,

Mallia

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Lung ultrasound (LUS) is a tool of growing interest in Rheumatoid Arthritis (RA) oligo- symptomatic ILD to avoid. Objective: We aimed to evaluate (i) the prevalence of pleural (PLUS) and parenchymal (PAUS) abnormalities in LUS in the RA population and their possible correlation to biomarkers; (ii) the predictivity of gender, smoking habits, previous infections (past COVID-19 tuberculosis), and treatments; (iii) the differences in LUS between sexes. Methods: We collected the data of 155 (15 early and 140 late) RA patients with mild respiratory symptoms, evaluating PLUS and PAUS, in fourteen lung areas and also summing the scores (LUS-T). Results: Only 13/155 (8.4%) were completely negative; LUS correlated to age (all parameters p 0.0001), rheumatoid factor IgM (PLUS p 0.0006, PAUS p 0.02, LUS-T p 0.001) and ACPA (p 0.001, 0.006, 0.001, respectively), and PLUS also correlated to IL6 (p 0.02). The male gender was predictive of all LUS evaluations (p 0.001, 0.05, 0.001, respectively), which were higher than in women (p 0.001, 0.01, 0.001, respectively). Other potential risk factors were independent, except biological treatments, which showed a low predictivity to PLUS (p < 0.05). Conclusions: We can conclude that LUS is a useful technique in RA low respiratory symptoms and correlates with age, the most important RA biomarkers, and male sex.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do Ultrasound Lung Abnormalities Correlate to Biomarkers and Male Gender in Rheumatoid Arthritis Patients? A Monocentric Cross-Sectional Study

Bandinelli,

Benucci,

Mallia

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Furthermore, the presence of pulmonary nodules [ 32 ], unilateral pleural effusion [ 33 ], pleural thickening, minimal pericardial effusion combined with pericardial thickening [ 34 ] and bone involvement in the form of erosions, soft tissue swelling, subchondral cyst formation and demineralization combined with a radiological UIP pattern should raise the suspicion of a connective tissue disease (CTD)-UIP.…”

Section: Radiology Of the Uip Patternmentioning

confidence: 99%

The usual Interstitial pneumonia pattern in autoimmune rheumatic diseases

Luppi,

Manfredi,

Faverio

et al. 2023

BMC Pulm Med

View full text Add to dashboard Cite

Usual Interstitial Pneumonia (UIP) is characterized by progression of lung parenchyma that may be observed in various autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis and connective tissue diseases. From a diagnostic point of view, a UIP pattern related to ARDs may display imaging and pathological features able to distinguish it from that related to IPF, such as the “straight-edge” sign at HRCT and lymphoplasmacytic infiltrates at histologic specimens. Multidisciplinary approach (MDD), involving at least pulmonologist, rheumatologist and radiologist, is fundamental in the differential diagnosis process, but MDD is also required in the evaluation of severity, progression and response to treatment, that is based on the combination of changes in symptoms, pulmonary function trends, and, in selected patients, serial CT evaluation. Differently from IPF, in patients with ARDs both functional evaluation and patient-reported outcomes may be affected by systemic involvement and comorbidities, including musculoskeletal manifestations of disease. Finally, in regards to pharmacological treatment, immunosuppressants have been considered the cornerstone of therapy, despite the lack of solid evidence in most cases; recently, antifibrotic drugs were also proposed for the treatment of progressive fibrosing ILDs other than IPF. In ARD-ILD, the therapeutic choice should balance the need for the control of systemic and lung involvements with the risk of adverse events from multi-morbidities and -therapies. Purpose of this review is to summarize the definition, the radiological and morphological features of the UIP pattern in ARDs, together with risk factors, diagnostic criteria, prognostic evaluation, monitoring and management approaches of the UIP-ARDs.

show abstract

“…In a study that involved 78 RA patients, Dinache et al [2] investigated the correlation between the disease characteristics in patients diagnosed with ILD and radiological features, observed on both chest X-rays and high-resolution computer tomography (HR-CT). Chest radiograph elements were found to differ according to gender, rheumatoid factor, and ACPA titers, while the HR-CT findings were also correlated with ACPA titer and different therapeutic agents.…”

mentioning

confidence: 99%