Lung damage in C57Bl mice following thoracic irradiation:: enhancement by chemotherapy

Steel, G. Gordon; Adams, K; Peckham, M. J.

doi:10.1259/0007-1285-52-621-741

Cited by 47 publications

(7 citation statements)

References 5 publications

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“…Strain differences make such conclusions speculative at present, since in C57 mice the optinmal time for Cy enhancement of lung colonies is 2-4 days (Steel & Adams, 1977). However, these particular mice may have delayed development of lung changes, since their median survivals following lung irradiation were between 200 and 310 days, whereas in CBA mice the medians ranged from 95 to 130 days, which are similar to the median survivals reported by other investigators (Steel et al, 1979).…”

Section: Discussionsupporting

confidence: 77%

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose

Collis¹,

Wilson²,

Jones³

1980

Br J Cancer

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Summary.-Cyclophosphamide (Cy) produces an interstitial pneumonitis in CBA mice. The extent of the lung damage has been quantified by measuring the increase in ventilation rate over 6 weeks after an i.p. injection of Cy 200,250 and 300 mg/kg. A dose-dependent response was found. When a preliminary ("priming") dose of Cy at 50 mg/kg was given 7, 9 or 14 days before a single large dose of 250 mg/kg, lung damage was reduced, as shown by a smaller increase in ventilation rate than in those receiving 250 mg/kg alone, and this difference was significant (P < 0 01) in the Day-14-and highly significant (P<0-001) in the Day-7-"primed" groups. When primed less than 7 days before, there was a relative increase in ventilation rate, which was statistically significant (P <0.01) in the Day-i -primed group. Similar effects were also seen in the survival of the mice.

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Section: Discussionsupporting

confidence: 77%

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose

Collis¹,

Wilson²,

Jones³

1980

Br J Cancer

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“…The previous studies have revealed that the time course of deaths in mice following thoracic irradiation is considerably prolonged [26]. The irradiated dose that resulted in 50% mortality was around 15 Gy, similar to the value found by Phillips et al [27] and Field et al [28].…”

Section: Discussionsupporting

confidence: 83%

Detection and Early Phase Assessment of Radiation-Induced Lung Injury in Mice Using Micro-CT

Saito

Murase

2012

PLoS ONE

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Radiation therapy is an important therapeutic modality for thoracic malignancies. However, radiation-induced pulmonary injuries such as radiation pneumonitis and fibrosis are major dose-limiting factors. Previous research shows that micro-computed tomography (micro-CT) can detect radiation-induced lung injuries a few months following irradiation, but studies to assess the early response of lung tissue are lacking. The aim of this study was to determine if micro-CT could be used to detect and assess early-phase radiation–induced lung injury in mice. Twenty-one animals were divided into three groups: normal (n = 7), one day after x-ray exposure (n = 7), and at four days after x-ray exposure (n = 7). The x-ray-exposed groups received a single dose of 20 Gy, to the whole lung. Histology showed enlargements of the air space (Lm: mean chord length) following irradiation. 40.5±3.8 µm and 60.0±6.9 µm were observed after one and four days, respectively, compared to 26.5±3.1 µm in normal mice. Three-dimensional micro-CT images were constructed and histograms of radiodensity - Hounsfield Units (HU) - were used to assess changes in mouse lungs. Radiation-induced lung injury was observed in irradiated mice, by the use of two parameters which were defined as shifts in peak HU between −200 to −800 HU (PeakHU) and increase in the number of pixels at −1000 HU (Number-1000). These parameters were correlated with histological changes. The results demonstrate that micro-CT can be used for the early detection and assessment of structural and histopathological changes resulting from radiation-induced lung injury in mice. Micro-CT has the advantage, over traditional histological techniques, of allowing longitudinal studies of lung disease progression and assessment of the entire lung, while reducing the number of animals required for such studies.

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“…Enhancement ofpneumotoxicity has been reported for simultaneous treatment with some cytostatics (cyclophosphamide, bleomycin, etc.) and ionizing radiation (4)(5)(6)(7).…”

Section: Resultsmentioning

confidence: 99%

“…Most reports in the literature have been of in vitro studies, and the biological effects examined have largely pertained to the topics of carcinogenesis, mutagenesis, teratogenesis, and cellkilling rates (1)(2)(3). Other studies have modeled combined injury to tissues as observed in management of malignant disease with cytostatics and high-level doses of ionizing radiation (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the Pneumotoxic Effect of Cadmium Acetate by Ionizing Radiation in the Rat

Salovsky¹,

Shopova²,

Dancheva³

et al. 1993

Environmental Health Perspectives

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Lung damage in C57Bl mice following thoracic irradiation:: enhancement by chemotherapy

Cited by 47 publications

References 5 publications

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose

Detection and Early Phase Assessment of Radiation-Induced Lung Injury in Mice Using Micro-CT

Enhancement of the Pneumotoxic Effect of Cadmium Acetate by Ionizing Radiation in the Rat

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