Lung damage from exposure to the fields of an electrohydraulic lithotripter

Hartman, C.; Child, Sally Z.; Mayer, Robert; Schenk, Eric A.; Carstensen, Edwin L.

doi:10.1016/0301-5629(90)90100-q

Cited by 92 publications

(36 citation statements)

References 4 publications

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“…However, concerns for its safety continue to be raised and addressed by members of the bioeffects research community (WFUMB 1998;AIUM 2000). These concerns are the result of numerous US-induced lung hemorrhage studies in mice, rats, rabbits, monkeys and pigs at exposure conditions similar to those used for scanning in humans Hartman et al 1990;Penney et al 1993;Raeman et al ,1996Frizzell et al 1994Frizzell et al ,2003Tarental and Canfield 1994;Zachary and O'Brien 1995;Harrison et al 1995;Baggs et al 1996;Holland et al 1996;O'Brien and Zachary 1997;Dalecki et al 1997aDalecki et al ,1997bWFUMB 1998;AIUM 2000;O'Brien et al 2000O'Brien et al ,2001aO'Brien et al , 2001bO'Brien et al ,2003aO'Brien et al ,2003bO'Brien et al ,2005Kramer et al 2001;Zachary et al 2001aZachary et al ,2001b.…”

Section: Introductionmentioning

confidence: 99%

Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs

O’Brien

Yang

Simpson

et al. 2006

Ultrasound in Medicine & Biology

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The objective of this study was to assess the threshold and superthreshold behavior of ultrasound (US)-induced lung hemorrhage in adult rabbits to gain greater understanding about species dependency. A total of 99 76 ± 7.6-d-old 2.4 ± 0.14-kg New Zealand White rabbits were used. Exposure conditions were 5.6-MHz, 10-s exposure duration, 1-kHz PRF and 1.1-μs pulse duration. The in situ (at the pleural surface) peak rarefactional pressure, p r(in situ) , ranged between 1.5 and 8.4 MPa, with nine acoustic US exposure groups plus a sham exposure group. Rabbits were assigned randomly to the 10 groups, each with 10 rabbits, except for one group that had nine rabbits. Rabbits were exposed bilaterally with the order of exposure (left then right lung, or right then left lung) and acoustic pressure both randomized. Individuals involved in animal handling, exposure and lesion scoring were blinded to the exposure condition. Probit regression analysis was used to examine the dependence of the lesion occurrence on in situ peak rarefactional pressure and order of exposure (first vs. second). Likewise, lesion depth and lesion root surface area were analyzed using Gaussian tobit regression analysis. Neither probability of a lesion nor lesion size measurements was found to be statistically dependent on the order of exposure after the effect of p r(in situ) was considered. Also, a significant correlation was not detected between the two exposed lung sides on the same rabbit in either lesion occurrence or size measures. The p r(in situ) threshold estimates (in MPa) were similar to each other across occurrence (3.54 ± 0.78), depth (3.36 ± 0.73 and surface area (3.43 ± 0.77) of lesions. Using the same experimental techniques and statistical approach, great consistency of thresholds was demonstrated across three species (mouse, rat and rabbit). Further, there were no differences in the biologic mechanism of injury induced by US and US-induced lesions were similar in morphology in all species and age groups studied. The extent of US-induced lung damage and the ability of the lung to heal led to the conclusion that, although US can produce lung damage at clinical levels, the degree of damage does not appear to be a significant medical problem.

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Section: Introductionmentioning

confidence: 99%

Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs

O’Brien

Yang

Simpson

et al. 2006

Ultrasound in Medicine & Biology

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“…This appears to be related to almost total reflection of the waves when they reach a tissue/air interface, resulting in local damage. 25 There is also a potential for the development of cardiac arrhythmias. The pressure threshold for this appears to be in the range of 1 to 10 MPa.…”

Section: Effects Of Shock Waves On Soft Tissuesmentioning

confidence: 99%

Extracorporeal shock-wave therapy in the management of chronic soft-tissue conditions

Speed

2004

The Journal of Bone and Joint Surgery. British volume

117

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“…ltrasound-induced lung hemorrhage is a welldocumented in vivo bioeffect in mice, [1][2][3][4][5][6][7][8][9][10][11][12] rats, [11][12][13][14][15][16][17][18][19][20] monkeys, 21 rabbits, 7,8 and pigs. 7,8,[22][23][24][25] Acoustic pressure lung hemorrhage thresholds have been estimated in mice, 1,[4][5][6]9,12 rats, 11,12,14,17 rabbits, and pigs.…”

mentioning

confidence: 99%

Superthreshold Behavior of Ultrasound‐Induced Lung Hemorrhage in Adult Rats

O’Brien

Simpson

Frizzell

et al. 2006

Journal of Ultrasound in Medicine

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Objective. The purpose of this study was to enhance the findings of an earlier ultrasound-induced lung hemorrhage study (Ultrasound Med Biol 2003; 29:1625-1634) that estimated pressure thresholds as a function of pulse duration (PD: 1.3, 4.4, 8.2, and 11.6 µs; 2.8 MHz; 10-s exposure duration [ED]; 1-kHz pulse repetition frequency [PRF]). In this study, the roles of PRF and PD were evaluated at 5.9 MPa, the peak rarefactional pressure threshold near that of the ED 50 estimate previously determined. Methods. A 4 × 4 factorial design study (PRF: 50, 170, 500, and 1700 Hz; PD: 1.3, 4.4, 8.2, and 11.6 µs) was conducted (2.8 MHz; 10-s ED). Sprague Dawley rats (n = 175) were divided into 16 exposure groups (10 rats per group) and 1 sham group (15 rats); no lesions were produced in the sham group. Logistic regression analysis evaluated significance of effects for lesion occurrence, and Gaussian tobit analysis evaluated significance for lesion depth and surface area. Results. For lesion occurrence and sizes, the main effect of PRF was not significant. The interaction term, PRF × PD, was highly significant, indicating a strong positive dependence of lesion occurrence on the duty factor. The main effect of PD was almost significant (P = .052) and thus was included in the analysis model for a better fit. Conclusions. Compared with the findings from a PRF × ED factorial study (J Ultrasound Med 2005; 24:339-348), a function that considers PRF, PD, and ED might yield a sensitive indicator for consideration of a modified mechanical index, at least for the lung.

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Lung damage from exposure to the fields of an electrohydraulic lithotripter

Cited by 92 publications

References 4 publications

Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs

Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs

Extracorporeal shock-wave therapy in the management of chronic soft-tissue conditions

Superthreshold Behavior of Ultrasound‐Induced Lung Hemorrhage in Adult Rats

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