Lung cysts in a patient with SARS-CoV-2

Aguilar, Pablo; Lucas, Ester Zamarrón de; Walther, Rodolfo Álvarez-Sala

doi:10.1016/j.medcle.2020.06.009

Cited by 4 publications

(2 citation statements)

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“…To date, its etiology is merely speculative, which is presumed to be secondary to parenchymal damage, pulmonary fibrosis, or low compliance, in some cases associated with mechanical ventilation but can also arise spontaneously in intermediate and late stages of ARDS; others assert that it is associated with the process of resorption of consolidation [ 12 - 19 ]. However, it is interesting to highlight that the infection by COVID-19 and other coronaviruses produces persistent airflow obstruction since it is common to find new emphysema, cysts, or attenuation mosaic in these infections, which is not the case with other viral infections [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Cystic Disease Associated With COVID 19 Pneumonia: An Emerging Atypical Manifestation

Muñoz-Palacio¹,

Syro²,

Pinzón³

et al. 2021

Cureus

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Chest tomography has played an essential role during the coronavirus disease 2019 (COVID-19) pandemic since it has allowed to suspect and diagnose the disease early and to assess the severity of lung involvement, predict the disease's course, and detect the complications associated with it. Certain chest CT findings have been reported in more than 70% of reverse transcription polymerase chain reaction (RT-PCR) test-proven COVID-19 cases, including ground-glass opacities, vascular enlargement, bilateral abnormalities, lower lobe involvement, and posterior predilection. In COVID-19-endemic regions, observing these chest CT findings should raise the suspicion of a possible COVID-19 diagnosis. Rare reported CT findings in RT-PCR test-proven COVID-19 cases include pleural effusion, lymphadenopathy, tree-in-bud sign, central lesion distribution, pericardial effusion, and cavitating lung lesions. The observation of one or more of these findings suggests an alternative diagnosis, although COVID-19 cannot be excluded from the differential diagnosis. Here, we report an interesting case of a patient with no relevant history presenting a COVID-19 infection which, as a complication, presented cystic lesions; we discuss its etiology briefly.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Cystic Disease Associated With COVID 19 Pneumonia: An Emerging Atypical Manifestation

Muñoz-Palacio¹,

Syro²,

Pinzón³

et al. 2021

Cureus

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“…Longer telomere length has been shown to be protective against the long-term sequela of pulmonary fibrosis from infection [6]. Less typical features of COVID-19 include cyst formation [7][8][9] which can lead to further complications including pneumothoraces and pneumomediastinum [10,11].…”

Section: Introductionmentioning

confidence: 99%

Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19

Igbinoba,

Capaccione,

Dsouza

et al. 2023

Imaging

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Background and aimImaging of patients with COVID-19 has provided unique insights into the pathophysiology of the infection. Cysts are a rare manifestation of the disease in the lung. The aim of this research was to compare COVID-19-positive patients with cysts on CT to patients without cysts and propose a mechanism for cyst formation in this patient population based on radiographic observations.Materials and MethodsOur HIPAA-compliant IRB-approved research project involved a retrospective review of 219 chest CT scans identified in COVID-19-positive inpatients and emergency room patients at Columbia University Irving Medical Center from February 27, 2020 to July 17, 2020. A thoracic radiologist with over 20 years of experience reviewed the images on lung window settings and identified the presence of cysts, their distribution (central or pleural based), and if there was an accompanying pneumothorax. The extent of consolidation of the entire lung on a scale of 0–16 and the presence of fibrosis were also documented.ResultsCysts were identified in 10 of the 219 patients. CT scans with cysts were obtained on average on day 57 of symptoms (range 16–115 days) compared to CT scans of those without cysts that were obtained on average on day 19 (range 0–89 days). The distribution of cysts was heterogeneous; six patients had multiple cysts while four were isolated. Seven cysts were peripheral in distribution while three were central. Two patients with cysts developed a subsequent pneumothorax. Fifty percent of those with cysts had been intubated.ConclusionsPatients with COVID-19 develop cystic lung lesions for at least two reasons; pleural-based lesions are more likely areas of infarction and central lesions with surrounding ground glass are more likely related to infection and/or mechanical ventilation.

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