Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1

Wang, Li; He, Jiang; Hu, Haoyue; Tu, Li; Sun, Zhen; Liu, Yanyang; Luo, Feng

doi:10.1111/jcmm.15274

Cited by 64 publications

(43 citation statements)

References 38 publications

(70 reference statements)

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“… 164 In a study on lung cancer, the researchers showed that exosomes derived from lung CSCs transferred cargo miR-210-3p to non-lung CSCs, which significantly contributed to the pro-metastasis phenotype. 162 Exosomal miR-210-3p upregulated the expression levels of N-cadherin, vimentin, MMP-9, and MMP-1, and downregulated E-cadherin expression in non-lung CSCs. 162 Mechanically, exosomal miR-210-3p promoted cancer cell metastasis by targeting FGFRL1.…”

Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 98%

“… 162 Exosomal miR-210-3p upregulated the expression levels of N-cadherin, vimentin, MMP-9, and MMP-1, and downregulated E-cadherin expression in non-lung CSCs. 162 Mechanically, exosomal miR-210-3p promoted cancer cell metastasis by targeting FGFRL1. 162 Hardin et al 165 investigated the roles of thyroid cancer stem-like cell-derived exosomal lncRNA MALAT1 and linc-ROR in thyroid cancer metastasis.…”

Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 98%

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The key roles of cancer stem cell-derived extracellular vesicles

Zhang

Yarden

et al. 2021

Sig Transduct Target Ther

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Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metastasis. Extracellular vesicles (EVs) are nano-sized particles released by different kinds of cells and have the capacity to deliver certain cargoes, such as nucleic acids, proteins, and lipids, which have been recognized as a vital mediator in cell-to-cell communication. Recently, more and more studies have reported that EVs shed by CSCs make a significant contribution to tumor progression. CSCs-derived EVs are involved in tumor resistance, metastasis, angiogenesis, as well as the maintenance of stemness phenotype and tumor immunosuppression microenvironment. Here, we summarized the molecular mechanism by which CSCs-derived EVs in tumor progression. We believed that the fully understanding of the roles of CSCs-derived EVs in tumor development will definitely provide new ideas for CSCs-based therapeutic strategies.

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Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 98%

Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 98%

The key roles of cancer stem cell-derived extracellular vesicles

Zhang

Yarden

et al. 2021

Sig Transduct Target Ther

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“…This process is sustained by EVs via delivery and release of their targets into a target cell(s). Alongside tumor progression, EVs have the capability of carrying out other critical processes, including cell proliferation, tumor growth [ 76 ], angiogenesis [ 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ], matrix remodeling, metastasis [ 75 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ], immune escape [ 69 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ], resistance to apoptosis [ 110 , 111 , 112 , 113 ], deregulation of energetic metabolism [ 114 , 115 , 116 , 117 ], sustaining proliferative signaling [ 94 , 118 , 119 , 120 ], evading growth suppression [ 121 , 122 , 123 ], deregulating and tumor-promoting inflammation [ 100 , 124 , ...…”

Section: Pathological Roles Of Evsmentioning

confidence: 99%

“…In another study, EV miR-105 was reported to stimulate invasion in both the respiratory and central nervous systems by inhibiting ZO-1 in endothelial cells, leading to enhanced cell migration [ 143 ]. Furthermore, it has been observed that EV miR-21 stimulates invasion of esophageal tumor cells by activating the programmed cell death 4 (PDCD4)/ c-Jun NH 2 -terminal kinase (JNK) axis [ 90 ].…”

Section: Pathological Roles Of Evsmentioning

confidence: 99%

“…The angiogenesis process has also been shown to be stimulated by miR-145-5p and miR-14-3p from lung cancer-derived EVs [ 151 ]. Moreover, in lung cancer cells, release of EV miR-21 stimulates angiogenesis in nontumor lung cells [ 90 ]. In another study, miR-9 exhibits proangiogenic activity by reducing expression levels of the SOCS5 gene and by promoting Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling, thereby supporting migration of endothelial cells and tumor angiogenesis [ 152 ].…”

Section: Pathological Roles Of Evsmentioning

confidence: 99%

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Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

Jurj

Pop-Bica

Slabý

et al. 2020

IJMS

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Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.

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Systematic Analysis of Tissue‐Derived and Biofluid Extracellular Vesicle miRNAs Associated with Prostate Cancer

et al. 2023

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Extracellular vesicles (EVs) are emerging as biomarker candidates for early detection of prostate cancer. Studies compare EV-microRNA (miRNA) expression in individuals with prostate cancer (PCa) with cancer-free samples for diagnostic purposes. The aim of this study is to review miRNA signatures to investigate the overlap between miRNAs enriched in PCa tissue and miRNAs enriched in EVs isolated from subjects with PCa biofluids (i.e., urine, serum, and plasma). Signatures dysregulated in EVs from PCa biofluids and tissue are potentially associated with the primary tumor site and might be more indicative of PCa at an early stage. A systematic review of EV-derived miRNAs and a reanalysis of PCa tissue miRNA sequencing data for comparison is presented. Articles in the literature are screened for validated miRNA dysregulation in PCa and compared with TCGA primary PCa tumor data using DESeq2. This resulted in 190 dysregulated miRNAs being identified. Thirty-one eligible studies are identified, indicating 39 dysregulated EV-derived miRNAs. The top ten markers identified as significantly dysregulated in the PCa tissue dataset TCGA (e.g., miR-30b-3p, miR-210-3p, miR-126-3p, and miR-196a-5p) have a significant expression change in EVs with the same directionality in one or several statistically significant results. This analysis highlights several less frequently studied miRNAs in PCa literature.

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Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1

Cited by 64 publications

References 38 publications

The key roles of cancer stem cell-derived extracellular vesicles

The key roles of cancer stem cell-derived extracellular vesicles

Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

Systematic Analysis of Tissue‐Derived and Biofluid Extracellular Vesicle miRNAs Associated with Prostate Cancer

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