Lung Clearance Index (LCI) in Patients with Bronchiolitis Obliterans: A Preliminary Report and Comparison to Cystic Fibrosis Patients

Gur, Michal; Yaacoby-Bianu, Karin; Ilivitzki, Anat; Bar‐Yoseph, Ronen; Nir, Vered; Toukan, Yazeed

doi:10.1007/s00408-016-9934-8

Cited by 12 publications

(13 citation statements)

References 34 publications

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“…As mentioned earlier, our group recently reported LCI measurement in post‐infectious BO . However, this measure requires expensive equipment and experienced technicians, and may take considerable time to achieve three technically acceptable tests.…”

Section: Discussionsupporting

confidence: 48%

“…Similar to our earlier findings, in the current study the severity of obstructive disease was higher in BO than in CF. LCI was also higher in BO patients, and FEF 25‐75% was lower.…”

Section: Discussionmentioning

confidence: 80%

“…The LCI technique was described in detail in our previous study . Multiple breath washout (MBW) measurements were performed using the Easy‐One Pro, MBW Module (NDD Medical Technologies, Zurich, Switzerland), as first described by Fuchs et al The system consists of a side stream ultrasonic transducer for temperature and humidity independent sampling of the molar mass (MMss), a mainstream ultrasonic transducer for flow sampling and a side stream infrared CO2 analyzer (DUET ETCO2 Module, Welch Allyn OEM Technologies, Beaverton OR) to correct the MMss signal for exhaled CO2.…”

Section: Methodsmentioning

confidence: 99%

“…LCI was studied mainly in BO post‐BMT. Recently, our group reported LCI measurements in post‐infectious BO . QOL in patients with BO, especially after lung and stem‐cell transplantation, was found to be significantly reduced …”

Section: Introductionmentioning

confidence: 99%

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Six‐minute walk, lung clearance index, and QOL in bronchiolitis obliterans and cystic fibrosis

Gur

Masarweh

Toukan

et al. 2018

Pediatric Pulmonology

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Introduction: The 6-min walk test (6MWT) predicts outcome in pulmonary hypertension. Recently, its use was reported in both cystic fibrosis (CF) and bronchiolitis obliterans (BO). While the 6MWT is a simple, non-invasive and inexpensive tool, lung clearance index (LCI) measurement requires expensive equipment and expertise. We aimed to evaluate 6MWT in BO and CF, and to compare to MBW (multiple breath washout), pulmonary function tests and quality of life (QOL).Methods: A prospective single center study assessing 6MWT, MBW, spirometry, whole-body plethysmography and QOL (SF-36 questionnaire) in BO and CF patients and correlations between them.Results: Thirty-three BO patients and 37 CF patients. LCI was significantly higher in BO (12.4 ± 4.2 vs 10.5 ± 3.4, P = 0.044) while FEF 25-75% was significantly lower in BO (43.9 ± 24.4 vs 60.8 ± 30.8, P = 0.014). 6MWD was 474.8 ± 76.3 in BO and 506.6 ± 70 in CF (P > 0.05). There was no correlation between 6MWD and LCI in these small study groups There were few correlation between spirometry prameters and 6MWD. In CF, SF-36 scores correlated with pulmonary functions. Conclusions:The 6MWT is an easy-to-perform test that may be helpful in chronic lung diseases in regions with limited resources. However,with the current limited data, 6MWT cannot replace LCI or spirometry as a marker of disease progression. Is is suggested that, together with QOL, the 6MWT may provide a global estimation of the physiological and general well-being of these patients. Further larger multi-center studies are warranted to evaluate the correlations of 6MWT with pulmonary physiology parameters in various chronic diseases. K E Y W O R D S bronchiolitis obliterans, cystic fibrosis, lung clearance index, quality of life, six-minute walk Michal Gur and Kamal Masarweh are equal contributers.

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Section: Discussionsupporting

confidence: 48%

“…Similar to our earlier findings, in the current study the severity of obstructive disease was higher in BO than in CF. LCI was also higher in BO patients, and FEF 25‐75% was lower.…”

Section: Discussionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Six‐minute walk, lung clearance index, and QOL in bronchiolitis obliterans and cystic fibrosis

Gur

Masarweh

Toukan

et al. 2018

Pediatric Pulmonology

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“…This seems promising for both clinical care and medical research. With respect to the histopathologic proclivity of BOS, namely obliterative bronchiolitis (OB), early diagnosis is extremely important because end‐stage OB is characterized by treatment‐refractory, irreversible fibrosis of the distal bronchioles …”

Section: Discussionmentioning

confidence: 99%

Multiple breath washout in pediatric patients after lung transplantation

Nyilas

Carlens²,

Price³

et al. 2018

American Journal of Transplantation

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Forced expiratory volume in 1 second (FEV ) from spirometry is the most commonly used parameter to detect early allograft dysfunction after lung transplantation (LTx). There are concerns regarding its sensitivity. Nitrogen-multiple breath washout (N -MBW) is sensitive at detecting early global (lung clearance index [LCI]) and acinar (S ) airway inhomogeneity. We investigated whether N -MBW indices indicate small airways pathology after LTx in children with stable spirometry. Thirty-seven children without bronchiolitis obliterans syndrome [BOS] at a median of 1.6 (0.6-3.0) years after LTx underwent N -MBW and spirometry, 28 of those on 2 occasions (≤6 months apart) during clinically stable periods. Additional longitudinal data (11 and 8 measurements, respectively) are provided from 2 patients with BOS. In patients without BOS, LCI and S were significantly elevated compared with healthy controls. LCI was abnormal at the 2 test occasions in 81% and 71% of patients, respectively, compared with 30% and 39% of patients with abnormal FEV /forced vital capacity (FVC). Correlations of LCI with FEV /FVC (r = 0.1, P = .4) and FEV (r = -0.1, P = .6) were poor. N -MBW represents a sensitive and reproducible tool for the early detection of airways pathology in stable transplant recipients. Moreover, indices were highly elevated in both patients with BOS. Spirometry and LCI showed poor correlation, indicating distinct and complementary physiologic measures.

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Zastosowanie metody wypłukiwania gazów w diagnostyce czynnościowej płuc u dzieci

Wawszczak

Peradzyńska

2017

Pediatria Polska

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Lung Clearance Index (LCI) in Patients with Bronchiolitis Obliterans: A Preliminary Report and Comparison to Cystic Fibrosis Patients

Cited by 12 publications

References 34 publications

Six‐minute walk, lung clearance index, and QOL in bronchiolitis obliterans and cystic fibrosis

Six‐minute walk, lung clearance index, and QOL in bronchiolitis obliterans and cystic fibrosis

Multiple breath washout in pediatric patients after lung transplantation

Zastosowanie metody wypłukiwania gazów w diagnostyce czynnościowej płuc u dzieci

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