Lung carcinoma in 36 patients with human immunodeficiency virus infection

Tirelli, Umberto; Spina, Michele; Sandri, Simonetta; Serraino, Diego; Gobitti, Carlo; Fasan, Marco; Sinicco, Alessandro; Garavelli, P. L.; Ridolfo, Anna Lisa; Vaccher, Emanuela

doi:10.1002/(sici)1097-0142(20000201)88:3<563::aid-cncr11>3.0.co;2-d

Cited by 127 publications

(100 citation statements)

References 16 publications

(8 reference statements)

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“…Accordingly, HIV-related malignancies, ie, Kaposi sarcoma and lymphoma are also declining. 9 However, other non-AIDS defining tumors, such as lung cancer, have increased in frequency in patients with HIV. 3,4 Recent studies have suggested that lung cancers are more aggressive in HIV patients; it usually occurs at a younger age, and there is a shorter survival time.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Recent studies have suggested that lung cancers are more aggressive in HIV patients; it usually occurs at a younger age, and there is a shorter survival time. 3,9 Why are there not then additional case reports of metastatic uveal carcinoma in HIV infection in the literature? One hypothesis may be that in the past, with poor survival, the overall prevalence of metastatic cancer in HIV patients was low; therefore, the prevalence of uveal metastases was also low.…”

Section: Discussionmentioning

confidence: 99%

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Uveal metastatic carcinoma in human immunodeficiency virus infection

Riske

Perlman

Moy

et al. 2002

Eye

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We report the occurrence of uveal metastatic carcinoma in two patients with longstanding HIV infection presenting with decreased visual acuity. In the first case, a 49-year-old man with a 6-year history of HIV infection presented with a 4-5 month history of blurred vision in his right eye. In the second case, a 53-year-old man with a 5-year history of HIV infection presented with a 3-week history of distorted and blurred vision in both eyes. In both cases, a choroidal metastatic carcinoma was ultimately discovered. To our knowledge, these are the first reported cases of metastatic uveal carcinoma in individuals with HIV infection. Currently, there have been dramatic improvements in treatment for HIV infection and longer survival times of infected individuals. This fact, together with reported increased frequencies and aggressiveness of carcinomas in HIV-infected individuals will likely result in increasing occurrences of uveal metastases from primary carcinomas in HIV.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Uveal metastatic carcinoma in human immunodeficiency virus infection

Riske

Perlman

Moy

et al. 2002

Eye

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“…These 2 findings are in positive correlation with the findings from other reports. [13][14][15][16][17][18][19] The role of immunosuppression has not been clearly defined. The results of our study suggest that immunosuppression may not play a role in lung cancer development.…”

Section: Lung Cancermentioning

confidence: 99%

“…A nadir in T-cell count and length of immunosuppression may be important to take into consideration. [19][20][21][22][23] The role of HIV-RNA viral load is still undefined. Our results, with the exception of few cases, did not show a correlation at all between HIV-RNA viral load and lung cancer.…”

Section: Lung Cancermentioning

confidence: 99%

Non-AIDS–Defining Cancers in New Orleans

Ruiz¹,

Johnson

Reske³

et al. 2013

J Int Assoc Provid AIDS Care

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Background: Non-AIDS-defining cancers in HIV-infected patients in the highly active antiretroviral therapy era have increased. To our knowledge a comprehensive review of non-AIDS-related malignancies in New Orleans has not yet been conducted. Methods: Databases from main institutions in New Orleans were queried retrospectively for the years 2001 to 2011. The International Classification of Diseases, Ninth Revision codes were used to search for HIV infection and cancer comorbidity. Results: A total of 16 patients were diagnosed with lung cancer (mean age 50 years) with 81% of the patients presenting with advanced stages. In all, 20 (mean age 47 years) were diagnosed with anal cancer, and 35% presented in late stages. In all, 14 patients (mean age 42 years) were diagnosed with Hodgkin Lymphoma, and 64% were diagnosed at late stage. A total of 5 women (mean age 44 years) were diagnosed with breast cancer with 40% of them presenting at late stage. Conclusion: Malignancies were diagnosed at late stages in the majority of the cases, presented with worse outcomes, and had higher recurrence rates. The role of HIV and other viruses (Epstein Barr virus, human papillomavirus) and the potential mechanisms or pathways of oncogene activation also need to be clarified.

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“…Obviamente, la mejora en la supervivencia de los pacientes VIH, el incremento en la edad de los pacientes infectados y la persistencia del hábito tabáquico harán que la incidencia de estos tumores pueda ir en aumento. En nuestra serie no se recogió el hábito tabáquico, si bien se ha constatado en algunos trabajos el incremento de neoplasias de pulmón en pacientes con infección por VIH, independientemente de la edad y del hábito tabáquico, propugnando como hipótesis la propia inmunosupresión celular mantenida y los efectos sobre la inmunidad del tratamiento anti-retroviral [41][42] .…”

Section: Neoplasias Definitorias De Sida Y Neoplasias No Definitoriasunclassified