Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control

Nalbandian, Ani; Yan, Bin; Pichugin, Alexander; Bronson, Roderick T.; Kramnik, Igor

doi:10.1038/onc.2009.32

Cited by 116 publications

(127 citation statements)

References 43 publications

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“…In another study investigating the effect of active TB on the survival of NSCLC patients, active TB was more frequently seen alongside squamous cell carcinoma (18). This situation is supported by the experimental study demonstrating that a chronic TB infection can trigger a series of events leading to the extensive remodeling of lung tissue or activation of a pathway resulting in a malignant transformation such as squamous cell metaplasia (19). On the contrary, in a meta-analysis of 37 case control and four cohort studies, the association was significant for adenocarcinoma (20).…”

Section: Discussionsupporting

confidence: 57%

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Köksal¹,

Kızılgöz²,

Özcan³

et al. 2017

Eurasian J Pulmonol

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Objective: The coincidence of tuberculosis (TB) and lung cancer (LC) at the initial diagnosis or the development of TB during the course of LC is a challenge in the management of both diseases. Herein we reviewed 10 LC patients who coincidentally had TB and evaluated the challenges in the management of both diseases. Methods:The files of patients were retrieved from an archive, and available study forms were completed. Results:The study included 10 LC and TB patients during a 4 year-period. The sites of TB were the lung (seven patients), mediastinal lymph nodes (LN) (one patient), cervical LN (one patient), and subcutaneous nodules (one patient). LC and TB were simultaneously diagnosed in four patients. The diagnosis of pulmonary TB was confirmed by sputum culture two months after LC diagnosis in four patients. TB was diagnosed later in the follow-up period in two patients. Only one patient with early-stage LC who had undergone surgical resection tolerated anti-TB therapy well. In one patient, TB caused the over-staging of LC. In one patient, LC had progressed during the course of anti-TB therapy. Hepatotoxicity was the leading adverse reaction due to anti-TB therapy. Conclusion:These patients highlighted the importance of considering TB in the course of LC, especially in countries with a high TB prevalence. TB may cause the advanced staging of LC at the initial diagnosis; chemotherapy may worsen the TB course or cause reactivation TB. Reactivation TB may be considered as the progression of LC without tissue diagnosis or sputum analysis. The tolerability of anti-TB therapy is poor in these patients.

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Section: Discussionsupporting

confidence: 57%

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Köksal¹,

Kızılgöz²,

Özcan³

et al. 2017

Eurasian J Pulmonol

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“…24 Nalbandian et al presented experimental evidence showing that chronic TB infection in the lungs is sufficient to cause the multistep transformation of cells, which can lead to tumor development. 25 We observed an increased risk of lung cancer in the TB cohort within the 12 years observation. Further studies should incorporate more experimental and epidemiological research to investigate the mechanisms of lung cancer induced by TB infection.…”

Section: Discussionmentioning

confidence: 61%

Pulmonary tuberculosis increases the risk of lung cancer

Pu³

et al. 2010

Cancer

156

136

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BACKGROUND:The possible effect of pulmonary tuberculosis (TB) on subsequent lung cancer development has been suspected, but the evidence remains inconsistent. The purpose of this study was to perform a nationwide population-based cohort study to investigate the risk of lung cancer after pulmonary TB infection. METHODS: This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Database. In total, 5657 TB patients and 23,984 controls matched for age and sex were recruited for the study from 1997 to 2008. RESULTS: The incidence rate of lung cancer (269 of 100,000 person-years) was significantly higher in the pulmonary TB patients than that in controls (153 of 100,000 person-years) (incidence rate ratio [IRR], 1.76; 95% confidence interval [CI], 1.33-2.32; P < .001). Compared with the controls, the IRRs of lung cancer in the TB cohort were 1.98 at 2 to 4 years, 1.42 at 5 to 7 years, and 1.59 at 8 to 12 years after TB infections. The multivariate Cox proportional hazards model revealed pulmonary TB infections (hazard ratio [HR], 1.64; 95% CI, 1.24-2.15; P < .001) and chronic obstructive pulmonary disease (HR, 1.09; 95% CI, 1.03-1.14; P ¼ .002) to be independent risk factors for lung cancer. CONCLUSIONS: Pulmonary infection with TB is associated with an increased risk of lung cancer. Cancer 2011;117:618-24.

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“…Furthermore, the laterality of TB and lung cancer was considerably correlated [7]. It was also recently shown that chronic TB infection causes cell dysplasia and SCC [13]. Mycobacterium infected macrophages play a key role in TB induced carcinogenesis by causing DNA damage.…”

Section: Case Reportmentioning

confidence: 91%

Squamous Cell Lung Cancer in a Male with Pulmonary Tuberculosis

Skowroński¹,

Iwanik

Halicka³

et al. 2015

Advances in Respiratory Medicine

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Lung cancer and pulmonary tuberculosis (TB) are highly prevalent and representing major public health issues. They share common risk factors and clinical manifestations. It is also suggested that TB predicts raised lung cancer risk likely related to chronic inflammation in the lungs. However, it does not seem to influence the clinical course of lung cancer provided that it is properly treated. We present a case report of a 57-year old male with concurrent TB and lung cancer. He was diagnosed with positive sputum smear for acid fast bacilli (AFB) and subsequent culture of Mycobacterium tuberculosis. Besides, his comorbid conditions were chronic hepatitis C virus (HCV) infection and peripheral artery disease (PAD). Later while on anti-tuberculous treatment (ATT) squamous cell lung cancer (SCC) was confirmed with computed tomography (CT) guided biopsy. Due to poor general condition the patient was not fit for either surgery or radical chemo-and radiotherapy. He was transferred to hospice for palliative therapy. We want to emphasize that both TB and lung cancer should be actively sought for in patients with either disorder. In addition, there is no doubt that these patients with lung cancer and with good response to TB treatment should be promptly considered for appropriate anticancer therapy. Case reportThe interaction between lung cancer and tuberculosis (TB) has been long established [1]. There is good evidence that preexisting TB is independently associated with an increased risk of lung cancer [2]. Besides, solid-organ malignancy raises the likelihood of TB reactivation particularly in patients with old healed TB lesions [3].A 57-year old severe underweight (bodymass-index (BMI) 15 kg/m 2 ) male was admitted to a respiratory ward with a history of 3-week long anorexia, fatigue, purulent cough and 1-month long fever. His cough started 6 months before. He reported significant weight loss of 15 kilos for 6 months. He had no chest pain and haemoptysis. As an out-patient he received the course of amoxicillin with clavulanic acid with short-lived improvement. Also, the patient complained of intermittent claudication after a short walking distance. He was a resident of the shelter for homeless for a few years. His primary profession was a garage worker whereas his most recent occupation was garbage sorting. There was a history of heavy smoking (30-pack years) and alcohol addiction. He had not been drinking for last 2 years. He had no evident contact with a confirmed TB source. In the distant past he underwent an ear-nose-throat operation for the nose deformity. On examination, he was undernourished, nor-

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Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control

Cited by 116 publications

References 43 publications

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Pulmonary tuberculosis increases the risk of lung cancer

Squamous Cell Lung Cancer in a Male with Pulmonary Tuberculosis

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