Lung cancer surgical treatment after solid organ transplantation: A single center 30-year experience

Drevet, Gabrielle; Duruisseaux, M.; Maury, Jean‐Michel; Riche, Benjamin; Grima, Renaud; Ginoux, M.; Mornex, Jean‐François; Tronc, François

doi:10.1016/j.lungcan.2019.10.023

Cited by 17 publications

(17 citation statements)

References 25 publications

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“…NSCLC has a high incidence of complications, and the postoperative survival rate of NSCLC patients is low [ 27 ]. LncRNAs have been confirmed in many studies as important participants in cancer progression [ 9 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Testis developmental related gene 1 promotes non-small-cell lung cancer through the microRNA-214-5p/Krüppel-like factor 5 axis

et al. 2021

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Non-small-cell lung cancer (NSCLC) is a frequent malignancy and has a high global incidence. Long noncoding RNAs (lncRNAs) are implicated in carcinogenesis and tumor progression. LncRNA testis developmental related gene 1 (TDRG1) plays a pivotal role in many cancers. This study researched the biological regulatory mechanisms of TDRG1 in NSCLC. Gene expression was assessed by reverse transcriptase quantitative polymerase chain reaction (RT–qPCR). Changes in the NSCLC cell phenotypes were examined using 5-ethynyl-2ʹ-deoxyuridine (EdU), cell counting kit-8 (CCK-8), wound healing, flow cytometry, and Transwell assays. The binding capacity between TDRG1, microRNA-214-5p (miR‑214-5p), and Krüppel-like factor 5 (KLF5) was tested using luciferase reporter and RNA immunoprecipitation (RIP) assays. In this study, we found that TDRG1 was upregulated in NSCLC samples. Functionally, TDRG1 depletion inhibited NSCLC cell growth, migration, and invasion and accelerated apoptosis. In addition, TDRG1 interacted with miR-214-5p, and miR-214-5p directly targeted KLF5. The suppressive effect of TDRG1 knockdown on NSCLC cellular processes was abolished by KLF5 overexpression. Overall, TDRG1 exerts carcinogenic effects in NSCLC by regulating the miR-214-5p/KLF5 axis.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Testis developmental related gene 1 promotes non-small-cell lung cancer through the microRNA-214-5p/Krüppel-like factor 5 axis

et al. 2021

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“…In addition, regarded as the independent risk factor for lung cancer, cigarette smoking has also been verified for the association with active SLE (67). Also, known as the main treatment for SLE patients, immunosuppressive drugs such as CTX and glucocorticoid which suppress immune surveillance by facilitating the survival and proliferation of abnormal cells have been reported to be related with its carcinogenic potential (68). Regarded as the first-line treatment for ILD and progressive skin-related diseases through inhibiting the progression of fibrosis, CTX makes a significant difference in the progression of malignancy because of the cellular injury during the process.…”

Section: Discussionmentioning

confidence: 98%

Association between systemic lupus erythematosus and lung cancer: results from a pool of cohort studies and Mendelian randomization analysis

Peng

Xiao-yue

et al. 2020

J Thorac Dis

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Background: Epidemiological evidence suggested that systemic lupus erythematosus (SLE) might be correlated with an increased risk of lung cancer. Nevertheless, few studies have comprehensively investigated their correlation and the causal effect remains unclear. With a meta-analysis and Mendelian randomization (MR) approach, we were able to systematically investigate the relationship between SLE and lung cancer risk.Methods: A systematic search of cohort studies was conducted using network databases from the inception dates to February 1, 2020. Meta-analysis was performed to calculate standardized incidence rate (SIR) and their 95% CI. Furthermore, utilizing 33 SLE-related single nucleotide polymorphisms as instrumental variables (IVs) identified by the latest genome-wide association studies (GWASs), we investigated the correlation between genetically predisposed SLE and lung cancer risk using summary statistics from the International Lung Cancer Consortium (11,348 cases and 15,861 controls). The Inverse variance-weighted method was applied to estimate the causality and we further evaluated the pleiotropy by means of the weighted median and the MR-Egger regression method. Subgroup analysis according to different histotypes of lung cancer was also conducted.Results: Through meta-analysis of 15 cohort studies involving 110,519 patients, we observed an increased risk of lung cancer among SLE patients (SIR =1.63, 95% CI, 1.39-1.90). Subgroup analysis suggested that female patients (SIR =1.28, 95% CI, 1.13-1.44) have a relatively higher lung cancer risk compared with male patients (SIR =1.15, 95% CI, 1.02-1.30). MR analysis indicated that genetically predisposed SLE was causally associated with an increased lung cancer risk (OR =1.045, 95% CI, 1.005-1.086, P=0.0276). When results were examined by histotypes, a causal relationship was observed between genetically predisposed SLE and squamous cell lung cancer (OR =1.065, 95% CI, 1.002-1.132, P=0.0429). Additionally, the results demonstrated the absence of the horizontal pleiotropy.Conclusions: Both meta-analysis and MR analysis results suggested that SLE was associated with an increased lung cancer risk. Further investigations are warranted to investigate the etiology underlying the attribution of SLE to lung cancer.

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“…It has been reported that immunosuppressive therapy, such as glucocorticoid and CTX, could also induce cytotoxic effects and suppress immune surveillance. Then the immune dysregulation of SLE may lead to the cellular damage and mutation, thus resulting in carcinogenesis of various cancers [25][26][27][28] . Overall, more studies are warranted to further investigate the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis

Gu¹,

Tang²,

Cui³

et al. 2021

Preprint

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Background Observational studies suggested that systemic lupus erythematosus (SLE) was associated with an increased risk of cancer, however, the causal effect remains unclear. We aim to determine the causality between SLE and cancer using a meta-analysis and Mendelian randomization (MR) approach. Methods A systematic search was conducted using PubMed to identify cohort studies published before January 21, 2021. Meta-analysis was performed to calculate relative risk (RR) and corresponding 95% confidence intervals (CI), and the potentially causal relationships identified by observational studies were further validated using two-sample Mendelian randomization. Results Through meta-analysis of 43 cohort studies involving 231,499 patients, we observed an increased overall cancer risk among SLE patients (RR = 1.62, 95% CI, 1.47–1.79). Site-specific analysis suggested that SLE patients were associated with an increased risk of 17 cancers. Mendelian randomization analysis indicated that genetically predisposed SLE was causally associated with an increased risk of lymphoma (odds ratio = 1.0004, 95% CI, 1.0001–1.0007, P = 0.0035), whereas a decreased risk of bladder cancer (odds ratio = 0.9996, 95% CI, 0.9994–0.9998, P = 0.00004) in European ancestry. However, no relationship was observed between genetically predisposed SLE and risk of colon, pancreatic, lung, cervical and Non-melanoma skin cancer in European ancestry, liver cancer and lung cancer in Asian ancestry. Conclusions Findings from meta-analysis and Mendelian randomization analysis suggested that SLE might be causally associated with an increased risk of lymphoma. However, inconsistent results were observed between SLE and risk of bladder cancer.

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Lung cancer surgical treatment after solid organ transplantation: A single center 30-year experience

Cited by 17 publications

References 25 publications

RETRACTED ARTICLE: Testis developmental related gene 1 promotes non-small-cell lung cancer through the microRNA-214-5p/Krüppel-like factor 5 axis

RETRACTED ARTICLE: Testis developmental related gene 1 promotes non-small-cell lung cancer through the microRNA-214-5p/Krüppel-like factor 5 axis

Association between systemic lupus erythematosus and lung cancer: results from a pool of cohort studies and Mendelian randomization analysis

Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis

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