Lung cancer stem cells—characteristics, phenotype

Hardavella, Georgia; George, Rachel; Sethi, Tariq

doi:10.21037/tlcr.2016.02.01

Cited by 53 publications

(51 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung adenocarcinoma and bronchoalveolar carcinoma has been associated with stem cells from the bronchoalveolar duct junction region. Studies on mouse models demonstrated the association of Matrixmetalloproteinase-10 (MMP10) with the maintenance and tumorigenicity of lung CSC (31,32).…”

Section: Conventional Therapy Targeted Therapymentioning

confidence: 99%

Lung cancer stem cells—origin, characteristics and therapy

Prabavathy¹,

Swarnalatha²,

Ramadoss³

2018

Stem Cell Investig.

View full text Add to dashboard Cite

show abstract

Section: Conventional Therapy Targeted Therapymentioning

confidence: 99%

Lung cancer stem cells—origin, characteristics and therapy

Prabavathy¹,

Swarnalatha²,

Ramadoss³

2018

Stem Cell Investig.

View full text Add to dashboard Cite

show abstract

“…CD44, principally, CD44v isoforms are CSC markers that play essential roles in the execution of the fundamental features of CSCs [19, 26, 101, 102]. Hence, CD44 has been proposed to be used for the isolation and enrichment of CSCs in lung cancers including MPM [22, 24, 26, 100, 103]. …”

Section: Cd44 a Putative Cancer Stem Cell Marker In Mpmmentioning

confidence: 99%

CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives

Cortes-Dericks

Schmid

2017

Respir Res

View full text Add to dashboard Cite

Malignant pleural mesothelioma (MPM) is a rare and highly drug resistant tumor arising from the mesothelial surfaces of the lung pleura. The standard method to confirm MPM is the tedious, time-consuming cytological examination of cancer biopsy. Biomarkers that are detectable in pleural effusion or patient serum are reasonable options to provide a faster and noninvasive diagnostic approach. As yet, the current biomarkers for MPM lack specificity and sensitivity to discriminate this neoplasm from other lung tumors. CD44, a multifunctional surface receptor has been implicated in tumor progression in different cancers including MPM. The interaction of CD44 with its ligand, hyaluronan (HA) has demonstrated an important role in modulating cell proliferation and invasiveness in MPM. In particular, the high expression levels of these molecules have shown diagnostic relevance in MPM. This review will summarize the biology and diagnostic implication of CD44 and HA as well as the interaction of both molecules in MPM that will demonstrate their potential as biomarkers. Augmentation of the current markers in MPM may lead to an earlier diagnosis and management of this disease.

show abstract

“…reported that CSCs were enriched in multiple phenotypically distinct subpopulations [20]. Such conflicting results are likely attributable to the heterogeneous origins and high plasticity of lung CSCs [8, 9]. Considering the inconsistencies in the markers identified for lung CSCs, it is preferable to define CSCs based on their biological functions.…”

Section: Discussionmentioning

confidence: 99%

“…It is now widely accepted that this heterogeneity is generated mainly by cancer stem cells (CSCs), which have both tumour-initiating ability and differentiation potential [5, 6]. Several studies have reported the isolation and characterization of lung CSCs, and several putative markers for lung CSCs have been identified, including CD133, CD44, CD166, aldehyde dehydrogenase (ALDH) and side population (SP) phenotypes [7–9]. However, controversies and uncertainties remain, and no consensus markers for lung CSCs have yet been identified [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Engineering cancer stem-like cells from normal human lung epithelial cells

et al. 2017

View full text Add to dashboard Cite

It has been proposed that a subpopulation of tumour cells with stem cell-like characteristics, known as cancer stem cells (CSCs), drives tumour initiation and generates tumour heterogeneity, thus leading to cancer metastasis, recurrence, and drug resistance. Although there has been substantial progress in CSC research into many solid tumour types, an understanding of the biology of CSCs in lung cancer remains elusive, mainly because of their heterogeneous origins and high plasticity. Here, we demonstrate that engineered lung cancer cells derived from normal human airway basal epithelial cells possessed CSC-like characteristics in terms of multilineage differentiation potential and strong tumour-initiating ability. Moreover, we established an in vitro 3D culture system that allowed the in vivo differentiation process of the CSC-like cells to be recapitulated. This engineered CSC model provides valuable opportunities for studying the biology of CSCs and for exploring and evaluating novel therapeutic approaches and targets in lung CSCs.

show abstract

Lung cancer stem cells—characteristics, phenotype

Cited by 53 publications

References 59 publications

Lung cancer stem cells—origin, characteristics and therapy

Lung cancer stem cells—origin, characteristics and therapy

CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives

Engineering cancer stem-like cells from normal human lung epithelial cells

Contact Info

Product

Resources

About