Lung cancer screening in high-risk individuals with annual low-dose chest CT in a community setting.

Patient Adherence to Screening for Lung Cancer in the US

“…Ten studies 12,[14][15][16][17]23,25,[27][28][29] (67%) were judged to have a low risk of confounder bias. Thirteen studies [12][13][14][15][16][17]19,20,22,23,[27][28][29] (87%) confirmed screening adherence through medical records or large database records. However, 12 studies 12,[14][15][16][17][18]20,22,23,25,27,28 (80%) did not have a follow-up time that was long enough to adequately assess periodic adherence beyond 1 year.…”

“…Fifteen studies (19 publications) involving a total of 16 863 individuals were included in this systematic review. 12 Ten studies were retrospective [12][13][14][15]17,19,[22][23][24][25][26][27] and 5 were prospective cohorts 16,18,20,21,[28][29][30] (Table 1). Eight studies 12,[17][18][19]23,25,27,28 were conducted in an academic setting and 7 [13][14][15][16]20,22,29 in a community setting.…”

“…12 Ten studies were retrospective [12][13][14][15]17,19,[22][23][24][25][26][27] and 5 were prospective cohorts 16,18,20,21,[28][29][30] (Table 1). Eight studies 12,[17][18][19]23,25,27,28 were conducted in an academic setting and 7 [13][14][15][16]20,22,29 in a community setting. Aside from 1 study, 18 adherence was evaluated for only the first subsequent screening.…”

“…The mean age of participants ranged from 50 to 75 years, the percentage of men ranged from 42% to 65%, the percentage of current smokers ranged from 42% to 76%, and the mean pack-year smoking history ranged from 32 to 53 pack-years (Table 2). [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Eligibility criteria varied across studies, with several reporting broad criteria not reflecting current guidelines. 13,23,24,[28][29][30] Two studies reported results for separate cohorts: Hirsh et al 17 subdivided individuals into those who received a screening reminder and those who did not, and Wildstein et al 28…”

“…Ten studies 12,[14][15][16][17][18][19][20]23,29 (67%) reported an adequate selection of the cohort, and 12 studies [12][13][14][15][16][17]19,20,23,[27][28][29] (80%) were judged to have adequately ascertained that participants underwent screening. Ten studies 12,[14][15][16][17]23,25,[27][28][29] (67%) were judged to have a low risk of confounder bias.…”