Lung cancer risk and mutagenicity of tea

Tewes, F.J.; Koo, Linda C.; Meisgen, T.J.; Rylander, Ragnar

doi:10.1016/s0013-9351(05)80148-3

Cited by 66 publications

(31 citation statements)

References 25 publications

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“…51 -59 - 60 The few previous studies of green tea and gastric cancer have yielded inconclusive results. Protective associations were reported from case-control studies in Japan and China. '…”

Section: ~58mentioning

confidence: 99%

Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study

Galanis

Kolonel

Lee

et al. 1998

International Journal of Epidemiology

155

151

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Background We report on the associations between the intake of certain foods and beverages and the incidence of gastric cancer in a cohort of 11 907 randomly selected Japanese residents of Hawaii (6297 women and 5610 men). MethodsThe daily intake of six beverages, cigarettes and alcohol and the weekly frequency of intake of 13 foods and food groups was estimated with a short food frequency questionniare. Over an average follow-up period of 14.8 years, 108 cases of gastric cancer (44 women, 64 men) were identified via linkage to the Hawaii Tumor Registry. ResultsIn gender-combined proportional hazards analyses, the consumption of fresh fruit seven or more times per week was associated with a significantly reduced risk of gastric cancer, compared to lower levels of consumption (relative hazard (RH): 0.6, 95% confidence interval (CI) : 0.4-1.0, P = 0.03). The combined intake of fresh fruit and raw vegetables was inversely associated with the risk of gastric cancer in the total cohort, and among the men (P < 0.05). No significant relationships were found between gastric cancer incidence and the intake of pickled vegetables, miso soup, dried or salted fish, or processed meats among either gender. Compared to non-drinkers, men who drank one cup of coffee per day had a significantly elevated risk of gastric cancer (RH: 2.5, 95% CI: 1.0-6.1, P= 0.05), but there was no evidence of a dose-response relationship. Cigarette smoking and consumption of alcohol were not related to gastric cancer, in analyses restricted to the men. Conclusions The results related to fruit and vegetable intake are consistent with an antinitrosating effect of these foods, while the unexpected association between coffee consumption and gastric cancer is difficult to explain and may represent a chance finding.

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Section: ~58mentioning

confidence: 99%

Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study

Galanis

Kolonel

Lee

et al. 1998

International Journal of Epidemiology

155

151

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“…Although animal studies have reported compelling results on the chemopreventive effects of green tea in lung cancer, human population-based studies have produced inconsistent findings. Some have found that green tea consumption is either associated with an increased 7 or reduced risk [8][9][10] of lung cancer, whereas others have found no effect. [11][12][13] In our previous studies, we have shown that GTE induces actin remodeling in transformed urothelial MC-T11 cells, antagonizes cigarette carcinogen 4-aminobiphenyl induced actin depolymerization in untransformed HUC-PC cells, and inhibits 4-aminobiphenyl induced motility in transformed MTC-11 cells using a unique in vitro bladder cancer carcinogenesis model.…”

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Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling

Jin

Zhang

et al. 2007

Laboratory Investigation

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Green tea polyphenols exhibit multiple antitumor activities in various in vitro and in vivo tumor models, and the mechanisms of action are not clear. Previously, we found that green tea extract (GTE) regulates actin remodeling in different cell culture systems. Actin remodeling plays an important role in cancer cell morphology, cell adhesion, motility, and invasion. Using proteomic approaches, we found GTE-induced expression of annexin-I, a multifunctional actin binding protein, in these cell lines. In this study, we aimed to further define the functional role of GTE-induced annexin-I expression in actin remodeling, cell adhesion, and motility in lung adenocarcinoma A549 cells. We found that GTE stimulates the expression of annexin-I in a dose-dependent fashion. The GTE-induced annexin-I expression appears to be at the transcription level, and the increased annexin-I expression mediates actin polymerization, resulting in enhanced cell adhesion and decreased motility. Annexin-I specific interference resulted in loss of GTE-induced actin polymerization and cell adhesion, but not motility. In fact, annexin-I specific interference itself inhibited motility even without GTE. Together, annexin-I plays an important role in GTE-induced actin remodeling, and it may serve as a potential molecular target associated with the anticancer activities of green tea.

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“…However, other case -control studies found either no association (Le Marchand et al, 2000;Bonner et al, 2005) or a positive association (Tewes et al, 1990). The wide range and crude categorisation of tea consumption, different study populations, choice of controls, inadequate control for confounding, and inevitable recall bias might have obscured HR ¼ hazard ratio; CI ¼ confidence interval.…”

Section: Discussionmentioning

confidence: 99%

Green tea consumption and lung cancer risk: the Ohsaki study

Kakizaki

Kuriyama

et al. 2008

Br J Cancer

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We examined the risk of lung cancer in relation to green tea consumption in a population-based cohort study in Japan among 41 440 men and women, aged 40 -79 years, who completed a questionnaire in 1994 regarding green tea consumption and other healthrelated lifestyle factors. During the follow-up period of 7 years (from 1995 to 2001), 302 cases of lung cancer were identified, and the Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). The multivariable-adjusted HRs of lung cancer incidence for green tea consumption of 1 or 2, 3 or 4, and 5 or more cups/day as compared to less than 1 cup/day were 1.14 (95% CI: 0.80 -1.62), 1.18 (95% CI: 0.83 -1.66), and 1.17 (95% CI: 0.85 -1.61), respectively (P for trend ¼ 0.48). This cohort study has found no evidence that green tea consumption is associated with lung cancer. , 1952 -2005).Evidence from in vitro and animal experiments has suggested that green tea polyphenols protect against lung cancer through their antimutagenic and antioxidant properties (Valcic et al, 1996;Okabe et al, 1997;Yang et al, 1998Yang et al, , 2005Fujimoto et al, 2002;Chen et al, 2004;Kuzuhara et al, 2007; Sadava et al, 2007). To the best of our knowledge, only two studies (of atomic bomb survivors and postmenopausal women) have investigated lung cancer risk in relation to green tea or total tea consumption (Zheng et al, 1996;Nagano et al, 2001), and both found no association.In a population-based prospective study of men and women in Miyagi Prefecture in northeastern Japan, where about 75% of the population drinks green tea everyday (Suzuki et al, 2004), we investigated further whether an association exists between green tea consumption and lung cancer risk. MATERIALS AND METHODSThe details of this Ohsaki National Health Insurance (NHI) cohort study have been published elsewhere (Tsuji et al, 1998;Kikuchi et al, 2006;Kuriyama et al, 2006;Nakaya et al, 2007). In brief, a baseline self-administered questionnaire was distributed to all NHI beneficiaries aged 40 -79 years living in the catchment area of the Ohsaki Public Health Center, Miyagi Prefecture, in northeastern Japan from October to December 1994. From 54 996 eligible individuals, 52 029 (94.6%) individuals responded to the survey. We considered the return of self-administered questionnaires signed by the participants to imply their consent to participate in the study. The study protocol was approved by the institutional review board of the Tohoku University Graduate School of Medicine.We excluded 776 individuals who had withdrawn from the NHI before we started the prospective study, 3038 individuals with a prior history of cancer, 6355 individuals with missing data on green tea consumption, and 420 individuals who had reported extreme daily energy intake (outside of the sex-specific cutoff points of lower 0.5% and upper 0.5%). Finally, 41 440 individuals were involved in the final analysis.The baseline survey questionnaire contained items on basic personal health informa...

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Lung cancer risk and mutagenicity of tea

Cited by 66 publications

References 25 publications

Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study

Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study

Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling

Green tea consumption and lung cancer risk: the Ohsaki study

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