Lung cancer presenting as an acute appendicitis

Callum, Jack; Paik, Julie; Hibbert, Michael

doi:10.1002/rcr2.703

Cited by 4 publications

(4 citation statements)

References 14 publications

(13 reference statements)

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“…Primary appendiceal neoplasms are incidentally found in 1-2% of appendectomies, with mucinous neoplasm (0.6%) and carcinoids (0.3-0.9) being the most common lesions [10,11]. Metastatic involvement of the appendix presenting as acute appendicitis is an even rarer entity, with few case reports documenting such incidences from carcinoma of breast, ovary, prostate, lung, kidney, stomach, colon, and hepatobiliary tract [12][13][14][15][16][17][18]. Unlike the growth pattern typical of primary appendiceal carcinoma, which starts from the mucosa and progresses outward, metastasis to the appendix involves the serosa first, followed by inward infiltration [14,16].…”

Section: Discussionmentioning

confidence: 99%

A Unique Presentation of Metastatic Gallbladder Carcinoma

Tian

Luu

Carpenter

et al. 2021

Case Reports in Surgery

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Gallbladder carcinoma can be challenging to diagnose and treat and usually leads to poor outcome, due to its aggressive nature and the nonspecific clinical presentation at early stage. We describe an interesting case of a 60-year-old female who presented with stage 3 appendiceal carcinoma after appendectomy was performed outside hospital. Further imaging workup demonstrated enlarged ovarian cysts and porcelain gallbladder. Upon exploration, she was found to have carcinomatosis and we proceeded with cytoreductive surgery (CRS) and hyperthermic intraperitoneal therapy (HIPEC). Final pathology demonstrated carcinoma from gallbladder primary.

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Section: Discussionmentioning

confidence: 99%

A Unique Presentation of Metastatic Gallbladder Carcinoma

Tian

Luu

Carpenter

et al. 2021

Case Reports in Surgery

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“…The age ranged from 44 to 85 years old with mean age of 60 years old. Six had small cell carcinoma [29,30,32,34,35,36], four had adenocarcinoma [28,37,39,40], one had squamous cell carcinoma [38], one had non-small cell lung cancer [33], and one had bronchogenic carcinoma [30]. Of those with documented degree of inflammation showed that nine patients or (82%), had complicated appendicitis [29,[31][32][33][34][36][37][38][39] compared with three uncomplicated [28,35,40] or (27%).…”

Section: Lung Cancermentioning

confidence: 98%

“…Thirteen cases of lung cancer metastasis causing acute appendicitis were found [28][29][30][31][32][33][34][35][36][37][38][39][40]. The age ranged from 44 to 85 years old with mean age of 60 years old.…”

Section: Lung Cancermentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the emergency department. Appendicectomy is one of the most common emergency operations performed. Appendicitis is attributed to lymphoid hyperplasia or faecolith causing obstruction of the appendiceal lumen. Other causes include helminth infection, primary appendiceal tumours, malignancy, and calculi. Metastatic malignancy causing acute appendicitis is very uncommon. In this article, we review the literature that exists reporting acute appendicitis attributed to metastatic diseases of the appendix, the malignancies that were identified, and the nature of the presentation. Methods:This study was performed following the Scale for the Assessment of Narrative Review Articles (SANRA). A literature review of existing case reports, abstracts, and studies was performed. PubMed and Google Scholar were used to search for the articles. Several cases were identified using the 'snowball method' where references were used to identify additional published literature.Results: Seventy-eight cases of acute appendicitis secondary to metastatic malignancies were identified. The most commonly reported metastatic malignancy causing appendicitis were breast, lung, gastric, and prostate. There was a total of n=34 (46%) of individuals with complicated appendicitis, n=40 (54%) with uncomplicated appendicitis, and four cases did not have degree of inflammation documented. The mean age of the patients was 57 years old. Conclusion:Appendicitis secondary to metastatic disease is a rare entity. This literature review has collated data identifying known primary malignancies that are associated with metastatic disease to the appendix. The most common have been identified as breast, lung, gastric and prostate primary malignancies. The mean age of patients in this review is 57. Patients presented with more complicated disease in comparison to the general population with acute appendicitis without malignancy. While rare, it important to be cognizant to the patient's previous malignancies even after the surveillance period has been completed. In this article we review the literature that exists reporting acute appendicitis attributed to secondary metastatic disease of the appendix, the malignancies that were identified and the nature of the presentation. When considering management of appendicitis, it is important to be cognizant as to whether the patient has had previous malignancies even after the surveillance period is over.

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“…Neuroendocrine tumours comprise 25% of all primary lung carcinomas, with the most common type of neuroendocrine, poorly differentiated tumours that have distant metastasis on presentation in the majority of cases [ 2 ]. Although widespread metastasis is common, metastasis to the appendix is rare, with only six cases of small cell lung carcinoma with appendiceal metastasis identified in the literature [ 3 ]. We present a case of a 60-year-old male with heavy smoking history who presented with appendiceal metastasis causing acute perforated appendicitis.…”

Section: Introductionmentioning

confidence: 99%

Metastatic small cell lung cancer presenting as acute appendicitis: a case report

Connell

Tai

et al. 2023

Journal of Surgical Case Reports

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We present a case of extensive stage small cell lung cancer presenting as perforated appendicitis secondary to an appendiceal metastasis. This is a rare presentation with only six reported cases in the literature. Surgeons must be aware of unusual causes for perforated appendicitis as in our case the prognosis can be dire. A 60-year-old man presented with an acute abdomen and septic shock. Urgent laparotomy and a subtotal colectomy were performed. Further imaging suggested the malignancy was secondary to a primary lung cancer. Histopathology demonstrated a ruptured small cell neuroendocrine carcinoma in the appendix with thyroid transcription factor 1 positive immunohistochemistry. Unfortunately, the patient deteriorated due to respiratory compromise and was palliated day six postoperatively. Surgeons should consider a broad differential diagnosis for the cause of acute perforated appendicitis as this can rarely be due to a secondary metastatic deposit from a widespread malignant process.

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Lung cancer presenting as an acute appendicitis

Cited by 4 publications

References 14 publications

A Unique Presentation of Metastatic Gallbladder Carcinoma

A Unique Presentation of Metastatic Gallbladder Carcinoma

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

Metastatic small cell lung cancer presenting as acute appendicitis: a case report

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