Lung cancer patients have the highest malignancy-associated suicide rate in USA: a population-based analysis

Rahouma, Mohamed; Kamel, Mohamed; Abouarab, Ahmed; Eldessouki, Ihab; Nasar, Abu; Harrison, S.; Lee, Benjamin; Shostak, Eugene; Morris, John C.; Stiles, Brendon M.; Altorki, Nasser K.; Port, Jeffrey L.

doi:10.3332/ecancer.2018.859

Cited by 51 publications

(39 citation statements)

References 30 publications

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“…Suicide rates have been shown to be higher in people with conditions associated with chronic pain or poor prognosis , including patients with cancer , neurological diseases such as amyotrophic lateral sclerosis or progressive multiple sclerosis . An analysis of the Surveillance, Epidemiology and End Results database 1973 to 2013 in the United States of America showed that SMRs for suicide ranged from 1.18 for prostate cancer to 4.17 for lung cancer . SMRs decreased over time for all cancers, but particularly for lung cancer.…”

Section: Resultsmentioning

confidence: 99%

Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017

et al. 2019

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Introduction In many countries, mortality due to suicide is higher among people living with HIV than in the general population. We aimed to analyse trends in suicide mortality before and after the introduction of triple combination antiretroviral therapy (cART), and to identify risk factors associated with death from suicide in Switzerland. Methods We analysed data from the Swiss HIV Cohort Study from the pre‐cART (1988‐1995), earlier cART (1996‐2008) and later cART (2009‐2017) eras. We used multivariable Cox regression to assess risk factors for death due to suicide in the ART era and computed standardized mortality ratios (SMRs) to compare mortality rates due to suicide among persons living with HIV with the general population living in Switzerland, using data from the Swiss National Cohort. Results and Discussion We included 20,136 persons living with HIV, of whom 204 (1.0%) died by suicide. In men, SMRs for suicide declined from 12.9 (95% CI 10.4‐16.0) in the pre‐cART era to 2.4 (95% CI 1.2‐5.1) in the earlier cART and 3.1 (95% CI 2.3‐4.3) in the later cART era. In women, the corresponding ratios declined from 14.2 (95% CI 7.9‐25.7) to 10.2 (3.8‐27.1) and to 3.3 (95% CI 1.5‐7.4). Factors associated with death due to suicide included gender (adjusted hazard ratio 0.58 (95% CI 0.38‐0.87) comparing women with men), nationality (1.95 (95% CI 1.34‐2.83) comparing Swiss with other), Centers for Disease Control and Prevention clinical stage (0.33 (95% CI 0.24‐0.46) comparing stage A with C), transmission group (2.64 (95% CI 1.71‐4.09) for injection drug use and 2.10 (95% CI 1.36‐3.24) for sex between men compared to other), and mental health (2.32 (95% CI 1.71‐3.14) for a history of psychiatric treatment vs. no history). There was no association with age. Conclusions Suicide rates have decreased substantially among people living with HIV in the last three decades but have remained about three times higher than in the general population since the introduction of cART. Continued emphasis on suicide prevention among men and women living with HIV is important.

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Section: Resultsmentioning

confidence: 99%

Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017

et al. 2019

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“…Lung cancer is a malignant tumor with high morbidity and mortality [25]. Since the progress of traditional medical technology and the emergence of new treatment methods, such as targeted therapy and immunotherapy, the prognosis and five-year survival rate of various tumors are significantly improved [26].…”

Section: Discussionmentioning

confidence: 99%

Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4

Yuan¹,

Gao²,

Yin³

et al. 2020

J. Cancer

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Lung cancer is a type of malignant tumor with high morbidity and mortality. Due to its complicated etiology and clinical manifestations, no significant therapeutic advance has been made. Lung squamous cell carcinoma (LSCC) is the most common type of lung cancer. To combat this disease, novel therapeutic targets are badly requirement. ASPM (Abnormal spindle-like microcephaly-associated protein) is involved in multiple cellular or developmental processes, such as neurogenesis and brain growth. ASPM is also reported widely expressed in multiple tumor tissues and involved in the development and progression of several cancers including lung cancer. However, the potential role on ASPM on LSCC is still unclear. In this study, we reported that ASPM was related to the poor prognosis of patients with lung squamous cell carcinoma. Our results further showed that ASPM depletion dramatically inhibited the proliferation of LSCC cells, consistent with the obviously decreased of cyclin D1(CCND1) and cyclin dependent kinases 4 (CDK4) expression. In vivo assays further confirmed ASPM ablation markedly blocked tumor growth in vivo compared with control. In addition, a co-expression was found between ASPM and CDK4 in human tumor tissues. Taken together, our data provides strong evidence that ASPM promotes lung squamous cell carcinoma proliferation in vitro and in vivo, and indicates its potential role as a LSCC therapeutic target.

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“…In general, the incidence rates of leukemia and suicide increased with the age of the patients, which is consistent with previous studies of elderly patients having other types of cancer. 22,33,34 The higher suicide rates of elderly leukemia patients might be related to their quality of life, outlook about life and death, and psychological condition such as the presence of depression. 11,35,36 Previous research has shown that the suicide rate among cancer patients in the United States is highest for whites and lowest for blacks.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have found that male sex, white race, marital status, and other risk factors are strongly correlated with the suicide rate of patients with certain types of cancer, such as kidney cancer, breast cancer, lung cancer, and head and neck cancer. 13,[20][21][22] Leukemia is a type of malignant proliferative disease involving hematopoietic stem cells. 23 There were 437,033 new leukemia patients identified worldwide in 2018, accounting for 2.4% of all new cancer patients and ranking 15th among new cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with suicide among leukemia patients: A Surveillance, Epidemiology, and End Results analysis

Cai

Huang

et al. 2020

Cancer Medicine

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Previous studies have found that the risk of suicide is higher in patients diagnosed with cancer than in the general population. We aimed to identify potential risk factors associated with suicide in leukemia patients by analyzing data obtained from the Surveillance, Epidemiology, and End Results (SEER) database. We screened the SEER database for leukemia patients added between 1975 and 2017, and calculated their suicide rate and standardized mortality rate (SMR) relative to the total United States population from 1981 to 2017 as a reference. Univariate and multivariate Cox regression analyses were used to determine the risk factors for suicide in leukemia patients. We collected 142,386 leukemia patients who had been added to the SEER database from 1975 to 2017, of whom 191 patients committed suicide over an observation period of 95,397 person‐years. The suicide rate of leukemia patients was 26.41 per 100,000 person‐years, and hence the SMR of the suicided leukemia patients was 2.16 (95% confidence interval [CI] = 1.85–2.47). The univariate and multivariate Cox regression analyses showed that a high risk of suicide was associated with male sex (vs. female: hazard ratio [HR] = 4.41, 95% CI = 2.93–6.63, p < 0.001), older age at diagnosis (60–69 years vs. ≤39 years: HR = 2.60, 95% CI = 1.60–4.23, p < 0.001; 70–79 years vs. ≤39 years: HR = 2.84, 95% CI = 1.72–4.68, p < 0.001; ≥80 years vs. ≤39 years: HR = 2.94, 95% CI = 1.65–5.21, p < 0.001), white race (vs. black: HR = 6.80, 95% CI = 1.69–27.40, p = 0.007), acute myeloid leukemia (vs. lymphocytic leukemia: HR = 1.59, 95% CI = 1.09–2.33, p = 0.016), unspecified and other specified leukemia (vs. lymphocytic leukemia: HR = 2.72, 95% CI = 1.55–4.75, p < 0.001), and living in a small city (vs. large city: HR = 2.10, 95% CI = 1.23–3.60, p = 0.007). Meanwhile, being a non‐Hispanic black (vs. Hispanic: HR = 0.06, 95% CI = 0.01–0.62, p = 0.019) was a protective factor for suicide. Male sex, older age at diagnosis, white race, and acute myeloid leukemia were risk factors for suicide in leukemia patients, while being a non‐Hispanic black was a protective factor. Medical workers should, therefore, provide targeted preventive measures to leukemia patients with a high risk of suicide.

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Lung cancer patients have the highest malignancy-associated suicide rate in USA: a population-based analysis

Cited by 51 publications

References 30 publications

Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017

Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017

Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4

Risk factors associated with suicide among leukemia patients: A Surveillance, Epidemiology, and End Results analysis

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