Lung cancer mortality attributable to residential radon: a systematic scoping review

Martin-Gisbert, Lucía; Ruano-Raviña, Alberto; Varela-Lema, Leonor; Penabad, Marina; Giraldo-Osorio, Alexandra; Candal-Pedreira, Cristina; Rey-Brandariz, Julia; Mourino, Nerea; Pérez‐Ríos, Mónica

doi:10.1038/s41370-022-00506-w

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…While the results of case-control studies provide a closer understanding of the pathophysiological features of the radon-smoking-cancer interaction at the individual level, however, they have limitations in the regional and population aspects. Paradoxically, the statistical description of these associations at the regional and national levels serves more as a qualitative assessment than a quantitative one, which allows public health services to obtain an overall perspective on the public health problem, enabling them to adjust their policies to reduce the burden of diseases caused by tobacco smoking and natural ionizing radiation (6,12).…”

Section: Discussionmentioning

confidence: 99%

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Contribution to the study of "smoking and radon" interaction in the lung cancer development across the Republic of Moldova

COREȚCHI,

OVERCENCO,

ABABII

et al. 2023

OH&RM

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Introduction. The most important risk factors for lung cancer are the tobacco smoking and residential radon exposure. The study of the interaction of smoking x radon as trigger factor for lung cancer morbidity in the Republic of Moldova was carried out. Material and methods. Data on tobacco smoking prevalence of the national study STEPS 2021, lung cancer morbidity data of 2012-2020 and data of radon measurements using RADTRAK2 during 2018-2021 were used. Data processing tools included summary statistics and cluster analysis. Results. The distribution of high radon values, the number of smokers and the lung cancer morbidity is uneven throughout the country. The formation of higher cluster combining all variables has proceeded by the formation of two clusters: 1. lung cancer incidence, lung cancer prevalence, number of total tobacco smokers, number of male smokers, number of female smokers, and number of urban smokers, 2. radon concentration and number of rural smokers. Conclusions. Study results demonstrate the leading role of tobacco smoking on morbidity among the adult population, regardless of gender in an urban environment with a rather low concentration of radon, and at the same time indicate the cumulative effect of smoking and increased radon concentration in rural areas due to the construction features of houses and lifestyle.

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Section: Discussionmentioning

confidence: 99%

“…The major risk factor contributing to the occurrence of LC is tobacco smoke, responsible for approximately 80% to 90% of all cases (5). Furthermore, the gas radon ranks among the other significant risk factors (6).…”

Section: Introductionmentioning

confidence: 99%

Contribution to the study of "smoking and radon" interaction in the lung cancer development across the Republic of Moldova

COREȚCHI,

OVERCENCO,

ABABII

et al. 2023

OH&RM

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“…Рак легких многие десятилетия занимает ведущее место в рейтинге причин смерти от онкологических заболеваний [1,2]. В 2021 г. в структуре смертности населения России от злокачественных новообразований наибольший удельный вес составляют опухоли трахеи, бронхов, легкого (16,8%).…”

Section: Introductionunclassified

“…+ ипилимумаб 1 мг/кг 1 раз в 6 нед. + 2 цикла ХТ (пеметрексед 500 мг/м2 + карбоплатин AUC5, цикл 21 день), при неплоскоклеточном НМРЛ 2 (2) Ниволумаб 360 мг 1 раз в 3 нед. + ипилимумаб 1 мг/кг 1 раз в 6 нед.…”

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Efficacy of immunotherapy in patients with non-small cell lung cancer

Lyadova,

Denisova,

Fedorinov

et al. 2024

Medicinskij sovet

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Introduction. Non-small cell lung cancer (NSCLC) is a form of lung cancer with high incidence and low overall survival. Immunotherapy is a promising treatment method for which the selection of optimal treatment regimens for each individual patient is important.Aim. To evaluate the effectiveness and safety of immune checkpoint inhibitors (ICIs) in patients with advanced NSCLC.Materials and methods. The study included 247 patients (190 men and 57 women) aged 37 to 87 years who received ICIs as monotherapy with nivolumab (n = 58; 23.4%), pembrolizumab (n = 78; 31.6%) and atezolizumab (n = 13; 5.3%), and in the form of combination chemoimmune therapy (n = 98; 39.7%). The objective response of the tumor to treatment was recorded in the presence of partial or complete regression of the tumor. The tumor response to treatment was determined in accordance with the iRECIST criteria.Results. Objective response was achieved in 20.6% of patients, of which 13.7% were on the first line setting, and 7% of patients were on the 2nd or more line setting. Disease control was recorded in 83.3% of patients. Patients receiving combination chemoimmune therapy had a better response to treatment than those receiving monotherapy (χ2 = 9.309; p = 0.020). Grade 3–4 immuno-related adverse events were observed only in 5 (2.02%) patients.Conclusions. NSCLC immunotherapy allows to achieve high rates of objective response and disease control (20.6 and 83.3%, respectively), with a small number of grade 3–4 immuno-related adverse events (2.02% according to our data), which indicates an acceptable safety profile.

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“…Residential radon exposure is up to 50% of the average annual exposure by ionizing radiation for the human population, this causes a significant health risk especially in areas with excessive radon levels [3]. Lung cancer is considered the main health effect of long-term radon exposure [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Radon Hazard of the Zhurinsky Fault for the Population in the Kuznetsk Coal Basin: Primary Results

Leshukov,

Legoshchin,

Larionov

2023

Sustainability

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The aim of this study is the primary assessment of radon hazard of the Zhurinsky fault of the Kuznetsk coal basin, in the territory of the Salair–Altai–Irtysh fold. Soil radon content, radon flux densities, their spatial characteristics and correlations with each other and with other factors were evaluated. We found that soil radon concentration varies within the range of 3599 to 14,413 Bq/m3 (mean value 8766 ± 569.8 Bq/m3), and radon flux density ranges from 23 to 147 mBq·m−2·s−1 with a mean value of 67.19 ± 1.31 mBq·m−2·s−1. A correlation with air temperature, pressure and humidity was found, which decreases with the depth of the measurements. All studied parameters in space are clustered (p ≤ 0.1). At the same time, the whole studied area in the vicinity of the tectonic disturbance should be classified as radon-hazardous, and residential structures located within its boundaries as potentially hazardous. Our study contributes to understanding the radon hazard of crustal faults.

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Lung cancer mortality attributable to residential radon: a systematic scoping review

Cited by 9 publications

References 48 publications

Contribution to the study of "smoking and radon" interaction in the lung cancer development across the Republic of Moldova

Contribution to the study of "smoking and radon" interaction in the lung cancer development across the Republic of Moldova

Efficacy of immunotherapy in patients with non-small cell lung cancer

Radon Hazard of the Zhurinsky Fault for the Population in the Kuznetsk Coal Basin: Primary Results

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