Lung cancer in women compared with men: stage, treatment, and survival

Ouellette, Denise; Desbiens, Geneviève; Emond, Claude; Beauchamp, Gilles

doi:10.1016/s0003-4975(98)00557-8

Cited by 74 publications

(40 citation statements)

References 11 publications

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“…While a number of studies have reported that women with non-small-cell lung cancer (NSCLC) live significantly longer than men after surgical or non-surgical treatment, [3][4][5][6] some other studies have shown no survival differences between genders. We, therefore, concluded that quantitative analysis combining data from multiple sources was necessary to resolve this issue.…”

Section: Female Gender Is An Independent Prognostic Factor In Non-smamentioning

confidence: 99%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

ATCS

115

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Purpose: It is not clear whether women with non-small-cell lung cancer (NSCLC) live significantly longer than men. Thus, we conducted a meta-analysis of published studies to quantitatively compare NSCLC survival data between genders. Materials and Methods: A MEDLINE Web search for computer-archived bibliographic data regarding overall survival differences between genders was performed. DerSimonian-Laird random effects analysis was used to estimate the pooled hazard ratio (HR). Results: We selected 39 articles as appropriate data sources, involving 86 800 patients including 32 701 women and 54 099 men. Combined HRs for women vs. men in studies using univariate and multivariate analyses respectively were 0.79 (p <0.0001) and 0.78 (p <0.0001). Pooled HRs for 3 study subgroups having (1) fewer than 30% stage I cases, (2) fewer than 50% adenocarcinoma cases, and (3) statistical adjustment for smoking status all indicated the survival advantage of women. Conclusion: This meta-analysis of published data concerning NSCLC patients indicated significantly better survival for women.

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Section: Female Gender Is An Independent Prognostic Factor In Non-smamentioning

confidence: 99%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

ATCS

115

View full text Add to dashboard Cite

show abstract

“…Differences between men and women have been variously attributed to differences in presentation, management and prognosis [18]. Presenting symptoms and management of lung cancer have been reported to be similar for men and women, but differences in histological types were found for women and a more favourable survival for women persists even when adjusted for stage [18][19][20]. In general, changes in trends for lung cancer surgery are very much influenced affected by the changes in incidence.…”

Section: Lung Cancermentioning

confidence: 99%

Trends in in-patient Hospital Utilization and Surgical Procedures for Breast, Prostate, Lung and Colorectal Cancers in Canada

Gao

Wai

Gaudette

2005

Cancer Causes Control

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“…Among 20 561 patients in the Polish cancer registry from 1995 to 1998 women had an RR of death of 1, compared to 1.21 (P = 0.001) in male by univariate analysis [4]. In a French cohort of 208 patients, when the data was adjusted for stage, women lived significantly more at each stage [16]. In a retrospective review of 7553 patients treated for NSCLC between 1974 and 1998 there is an overall median survival of 12.4 months for women and 10.3 for men (P <0.001) and the advantage is present for all stages (P <0.001) [17].…”

Section: Therapeutic Outcomesmentioning

confidence: 94%

Women and lung cancer

Novello

Baldini

2006

Annals of Oncology

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epidemiologyIn the early 1900s lung cancer was reported to be rare in women, but has, starting from the 1960s, progressively reached epidemic proportion, surpassing breast cancer in 1987 and becoming the leading cause of cancer deaths among women. Over the past 30 years there has been a four-fold increase in lung cancer in women (altering the male/female ratio of the disease) and it is estimated that this rise will not plateau until after 2010 [1]. Observational studies suggest differences in the histologic presentation [2-4] and age distribution of lung cancer between men and women (Table 1). Lung cancer kills more women in the United States each year than in any other country in the world: over 170 000 patients die from lung cancer and over 70 000 are women (29% of all cancer deaths), that means more deaths than breast, ovarian and uterine cancer combined together. Small cell lung cancer and adenocarcinoma are more common in women than in men (26.6% vs. 19.9%, P <0.001 and 21.6% vs. 9.6%, P <0.001, and younger lung cancer patients are more likely to be female than male (age <50 years: 23.3% vs. 12%, P <0.001) [4]. risk factorsControversy exists as to whether women are more or less sensitive to the carcinogenic effect of tobacco smoke. Several case-control studies seem to suggest that women are more vulnerable to tobacco carcinogens than men. In 1993, Risch et al. investigated the male-female differences in more than 800 patients with lung cancer and they showed that, compared with a non-smoking population, the relative risk of developing lung cancer was 27.9 in women vs. 9.6 in men at the same level of lifelong exposure (40 pack-year) [5]. An American Health Foundation case-control study including 1108 men with lung cancer, 781 women with lung cancer and 2070 controls, found that, given the same level of exposure to cigarette smoke, women had approximately 1.5-fold higher estimated relative risk of developing lung cancer than men. The sex difference, in estimated relative risk, was statistically-significant for all histological subtypes of lung cancer although slightly greater for adenocarcinoma and small cell lung cancer than for squamous cell carcinoma [6]. On the contrary, cohort studies have reported that there are no significant differences in susceptibility between females and males [7].However, important differences exist between the sexes: women who smoke are more likely to develop an adenocarcinoma, and never-smoking females are more likely to develop lung cancer than men who have never smoked. Several studies showed that women may be more predisposed to molecular aberrations caused by the carcinogenic effects of tobacco smoke. Kure et al. found a higher frequency of G:C/T:A mutation in the p53 gene and a higher average of DNA adduct level in lung tumors from women even if the level of exposure to carcinogens was lower among women than men [8]. In the lung of female smokers an increased expression of the CYP1A1 gene has been found [9]; the CYP1A1 gene codes for an enzyme (phase 1 enzyme) that metaboli...

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Lung cancer in women compared with men: stage, treatment, and survival

Cited by 74 publications

References 11 publications

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Trends in in-patient Hospital Utilization and Surgical Procedures for Breast, Prostate, Lung and Colorectal Cancers in Canada

Women and lung cancer

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