Lung cancer in the Indian subcontinent

Noronha, Vanita; Pinninti, Rakesh; Patil, Vijay; Joshi, Amit; Prabhash, Kumar

doi:10.4103/2278-330x.187571

Cited by 77 publications

(40 citation statements)

References 47 publications

(46 reference statements)

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“…Globally, there have been important changes in incidence trends amongst men and women, histology, and also incidence in nonsmokers [1]. Several epidemiological observations performed across varied demographic cohorts in India confirm the significant burden of lung cancer in India [2]. Smoking tobacco, both cigarettes and beedis, is the principal risk factor for causation of lung cancer in Indian men; however, among Indian women, the association with smoking is not strong, suggesting that there could be other risk factors besides smoking [2].…”

Section: Introductionmentioning

confidence: 90%

“…Several epidemiological observations performed across varied demographic cohorts in India confirm the significant burden of lung cancer in India [2]. Smoking tobacco, both cigarettes and beedis, is the principal risk factor for causation of lung cancer in Indian men; however, among Indian women, the association with smoking is not strong, suggesting that there could be other risk factors besides smoking [2]. There is a dearth in our current understanding of the changing Manuscript received: 4 th September 2017 Reviewed: 14 th September 2017 Author Corrected: 20 th September 2017 Accepted for Publication: 26 th September 2017 epidemiological trends of lung cancer among Indian patients.…”

Section: Introductionmentioning

confidence: 91%

“…While the global trend of a rise in adenocarcinoma appears to be paralleled in India, we do not completely understand the alarming rise in the incidence of lung cancer among the nonsmokers. [2]. The survey conducted in Uttar Pradesh by Misra and others showed that the incidencewas 4.2 per 10,000 hospital admissions and 2.% of all malignancies [3].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological pattern of lung cancer in a tertiary care centre-A prospective observational study

C¹,

Kumari²,

Jayaprakash³

2017

Int J Med Res Rev

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Background: Lung cancer is a leading cause of morbidity and mortality worldwide. An increasing incidence of lung cancer has been observed in India.Aim of the study: To evaluate epidemiological profile oflung cancer in a tertiary care centre, South Kerala. Methodology: Prospective observational study, conducted at Medical College, Thiruvananthapuram, South Kerala, in 160 consecutive patients with histopathological diagnosis of lungcancer. Data on demography, symptoms, smoking status, physical findings, diagnostic modalities, histological diagnosis, and TNM stagewere recorded using a structured questionnaire. For inferential statistics, comparison between groups of qualitative variables were analysed by chi-square test and quantitative variables were compared by student t test. P value of less than 0.05 was considered as level of significance.Results: Out of 160 consecutive lung cancer patients, 86.9% of patients were males. Male to Female ratio is 6.6: 1.50-59 yrs was the commonest age group affected.11.3% were nonsmokers. 67.5% of smokers were having smoking index more than 500.COPD was the commonest co morbidity (58%) in the study.Adenocarcinoma (41.9%) was the commonest histological type in our study and this was the commonest histologicaltype seen in females and nonsmokers. In smokers, squamous cell carcinoma (91.3%) was more common. 66.9% of patients were at TNM stage 3 or 4 at the time of diagnosis only 5% of patients were in surgically resectable stage. Conclusion: It was found out that Adenocarcinoma was the most frequent histopathological type and majority of patients were at advanced stage at the time of diagnosis.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Epidemiological pattern of lung cancer in a tertiary care centre-A prospective observational study

C¹,

Kumari²,

Jayaprakash³

2017

Int J Med Res Rev

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“…The prevalence of respiratory system malignancies is quite variable in different parts of India. In most studies, including reports of National Cancer Registry Program (NCRP) [10][11] from Bhopal, Delhi, and Mumbai; and other studies; laryngeal cancer was the most common site. The present study was in agreement with those where lung was the topmost site for malignancy in males.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological profile of lung cancer in North Indian population

Bhaskar

Singh

et al. 2018

IJRDPL

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Lung cancer is the most common cancer representing approximately 12% of all new cancers. It is also the most frequent type of cancer in males and remains the most a common cause of cancer-related mortality in both sexes. An increasing incidence of lung cancer has been observed in India. We studied the clinical and pathological profile of patients with lung cancer in a tertiary care center. We performed a retrospective analysis of histopathologically proven cases of bronchogenic carcinoma admitted in our hospital. In our study we included 203 patients with confirmed cases of lung cancer. Male to female ratio was 8.2:1. The common age group being 40-60 years, 9.86% of the patients were less than 40 years old age. Smoking was found to be the main risk factor for 81.77% patients. The most frequent symptom was a cough (72.90%) followed by fever (58.12%). The most common radiological presentation was mess lesion (46.31%). The most common histopathological type was squamous cell carcinoma (SCC) (44.83%) followed by adenocarcinoma (19.78%) and small cell lung carcinoma (SCLC) (16.75%). The majority patients (73.29%) were diagnosed in the later stages of the disease (3b and 4). Squamous cell carcinoma was the most frequent histopathological form. Smoking remains the major risk factor for lung cancer.

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“…[ 1 ] It is increasingly being recognized in India and is ranked fourth in terms of incidence. [ 2 ] Curative surgical resection remains the best therapy for patients with localized non small cell lung cancer, and commonly performed operations include lobectomy and pneumonectomy. [ 3 ] Prior to surgical resection, investigations are carried out to evaluate the respiratory sufficiency.…”

Section: Introductionmentioning

confidence: 99%

Comparison of predicted postoperative forced expiratory volume in the first second (FEV1) using lung perfusion scintigraphy with observed forced expiratory volume in the first second (FEV1) post lung resection

et al. 2020

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Lung perfusion scintigraphy is done as a part of preoperative evaluation in lung cancer patients for the prediction of postoperative forced expiratory volume in the first second (FEV1). This study was performed to see the accuracy of prediction of postoperative FEV1 by perfusion scintigraphy for patients undergoing lobectomy/pneumonectomy by comparing it with actual postoperative FEV1 obtained by spirometry 4–6 months after surgery. We retrospectively reviewed 50 surgically resected lung cancer patients who underwent preoperative spirometry, lung perfusion study, and postoperative spirometry. Pearson’s correlation coefficient was used to evaluate the relationship between predicted postoperative FEV1 (PPO FEV1) by lung perfusion scintigraphy and postoperative actual FEV1 measured by spirometry. Agreement between the two methods was analyzed with Bland–Altman method. The correlation between the PPO FEV1 and actual postoperative FEV1 was statistically significant (r = 0.847, P = 0.000). The correlation was better for pneumonectomy compared to lobectomy (r = 0.930 [P = 0.000] vs. 0.792 [P = 0.000]). The agreement analysis showed a mean difference of −0.0558 with a standard deviation (SD) of 0.284. The limits of agreement vary over a wide range from −−0.625 to 0.513 L (mean ± 2 SD) for the entire group. For pneumonectomy, the mean difference was −0.0121 and SD 0.169 with limits of agreement varying between −0.30 L and 0.30 L. For lobectomy, the mean difference was −0.0826 and SD 0.336 with limits of agreement varying between −0.755 L and 0.590 L. Postoperative FEV1 predicted using lung perfusion scintigraphy shows good correlation with actual postoperative FEV1 and shows reasonably good agreement in patients undergoing pneumonectomy. The limits of agreement appear to be clinically unacceptable in patients undergoing lobectomy, where single-photon emission computed tomography (SPECT) or SPECT/CT techniques may improve prediction.

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Lung cancer in the Indian subcontinent

Cited by 77 publications

References 47 publications

Epidemiological pattern of lung cancer in a tertiary care centre-A prospective observational study

Epidemiological pattern of lung cancer in a tertiary care centre-A prospective observational study

Clinico-pathological profile of lung cancer in North Indian population

Comparison of predicted postoperative forced expiratory volume in the first second (FEV1) using lung perfusion scintigraphy with observed forced expiratory volume in the first second (FEV1) post lung resection

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