Lung cancer in patients younger than 40 years in a multiracial Asian country

Ck, Liam; Lim, Kuan‐Hon; Wong, Chan‐Yuan

doi:10.1111/j.1440-1843.2000.00275.x

Cited by 22 publications

(7 citation statements)

References 25 publications

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“…[17][18][19]21,23,[29][30][31][32][33][34] A study from Scotland [20] showed that small-cell carcinoma was the predominant type, while a study from Kuwait [22] showed that squamous cell carcinoma was the predominant type in young patients. Bhattacharya [16] from India has reported squamous cell carcinoma as being the predominant histological type, and this is the case in the present study also.…”

Section: Discussionmentioning

confidence: 99%

Comparison between young and old patients with bronchogenic carcinoma

2009

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Section: Discussionmentioning

confidence: 99%

Comparison between young and old patients with bronchogenic carcinoma

2009

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“…The incidence of lung cancer among young adults has been found to be around 1.2% to 6.2% (under 40 years), 5.3% (under than 45 years) [1][2][3][4], and 13.4% (under 50 years) [5]. However, previous reports have shown trends of increasing incidence rates of lung cancer among young patients [6,7].…”

Section: Introductionmentioning

confidence: 73%

Metastatic Adenocarcinoma in the Young Adult

Mehta¹,

Jain²,

Desai³

et al. 2017

Arch Surg Oncol

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We report a case of metastatic adenocarcinoma pleura in a non-smoking 29-year-old man. X-ray Chest revealed Left sided repeated pleural effusion despite repeated tapping. CT revealed a moderate Left sided pleural effusion. A VATS biopsy of the Left Pleural Nodules and Left lung nodules revealed a metastatic adenocarcinoma. He was a non-smoker and molecular markers revealed an EGFR Mutation and were started on oral TKI. He had near complete resolution after 6 months except for mild thickening of the pleura at the base.

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“…It can be seen that no matter which lung cancer screening guidelines you choose, there were many patients with lung cancer missed according to the age standard, especially female patients. Previous studies showed that the incidence of lung cancer in young adults were around 1.2 to 6.2% (less than 40 years), 5.3% (under 45 years), and 13.4% (less than 50 years) [47][48][49][50][51]. Therefore, with an increasing incidence of lung cancer in young people, it have gradually become a disease group that can not be ignored [52,53].…”

Section: Discussionmentioning

confidence: 99%

Current lung cancer screening guidelines may miss high-risk population: a real-world study

Bao

et al. 2021

BMC Cancer

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Background Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population. We therefore did a real-world study using the current lung cancer screening guidelines to a health examination population in China to determine the proportion of lung cancer cases that have been missed. Methods A real-world cohort study of screening, with the use of low-dose computed tomography, was conducted among people who took yearly health checkup in health management center of West China Hospital between 2006 and 2017. We respectively used current guidelines including lung cancer screening guidelines of the U.S. Preventive Services Task Force (USPSTF) and expert consensus on low dose spiral CT lung cancer screening in China. Results In a total of 15,996 participants with health examination who completed the baseline screening, 6779 (42.4%) subjects had at least one positive finding, and 142 (2.1%) cases of lung cancer were screened positive. The false positive rate was 97.9%. Of 142 lung cancer cases detected in our study, only 9.2% met the lung cancer screening guidelines proposed by the USPSTF, and 24.4% met that of China. The rates of missed diagnosis were as high as 90.8 and 75.6% respectively. In addition, we did an in-depth analysis by gender. We found that among male patients with lung cancer, the proportion of smokers was 75%, and the proportion of young people under 50 was 23.2%. Among female patients with lung cancer, the proportion of smokers was only 5.8%, and the proportion of young people under 50 was up to 33.3%. Conclusions The rate of missed diagnosis was as high as 90.8% applying the current lung cancer screening guidelines to the health examination population in China. Further study to determine screening guidelines for targeted populations, is warranted.

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Lung cancer in patients younger than 40 years in a multiracial Asian country

Abstract: Younger lung cancer patients were more likely than older patients to have never smoked, to have adenocarcinoma, and to present with poorer performance status and with more advanced-stage non-small cell lung cancer.

Cited by 22 publications

References 25 publications

Comparison between young and old patients with bronchogenic carcinoma

Comparison between young and old patients with bronchogenic carcinoma

Metastatic Adenocarcinoma in the Young Adult

Current lung cancer screening guidelines may miss high-risk population: a real-world study

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